dbPTM

UTP22_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UTP22_SCHPO
UniProt AC	O94676
Protein Name	U3 small nucleolar RNA-associated protein 22
Gene Name	utp22 {ECO:0000250\|UniProtKB:P53254}
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	1097
Subcellular Localization	Nucleus, nucleolus .
Protein Description	Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly..
Protein Sequence	MNGLKREHESSSSQDGSKTPETEYDSHVDSIEDIHSLASKRKKLNEKKENLEDLTLLKTSAFELKLNELIREISVRGKYFRHANTFVEKIKDLIFKTPVIPETNFWSACKNLEKDKKVIVPLAEPLSAKDTNLRASFVPPKTVTPGIFSCSNKFFLNPDGWSYDLFLEIPESIFTQKDYLNGRYFRKRAFYLTCIAKHLLENLGNEVKLEFVAFNDDIRRPILAILPESKGFAATGKRFTVFLIPTVRQIFPVSKLLPHKNAIRDFMEHEELKPTPFYNNSVLEEQNLLFYRDLVKKYSVNPQFLDACGLGSTWLNMRGFSSSIHSNGFGLLEWYVLMALLMSSTGLPAGNVLNTYLTAAQFFKSMLQFLSSKNLTSTLFKLNADSSNLKIGNGHLPTLIDCNTGFNLLGKMKQSFFEYFQASCRHTLNLLDENANYNFSKIFITHVNVPALEFDVSGCIPLEPKELEDPNFCRKTDLDSPYSLYLEYTWDLLQHALGDRVCQIILYSSICTSCSINESLKTKLPKLISFGLLLNPDALLRLVDIGPSPDDTVGSQKFREFWGEVSELRKFKNGSIAESVYWECSSPDERIRIPQRIIRHILNRHLGNNVGDRVSFRNEKFRVYVHSKISPNTDTYNEYVPVMEAYNEAVKSLINLSDIPLSIAEILPADESLRYSSSSVPFYESSTCAPIDVVFQFESSSKWPDELEGIQRTKIAFLLKIAELLEALDNVERASVGLENTDNPTHNCCFLQVLFSNNFTFRYRLRNDREIFFWKSLERNPSTKLSAQKGLYAYEHMFQFIPRHTLAIQAICQAHRSYSMAVRLAKHWFYSHLLTDHVTDEVIELLVASVYINSSSWRTTSSGETSFCRMLHFLAHWDWRFDPLIINSNGKLPHDVRHQATEKLESIRKQDVAIAHNAYYIITDYDFDGNHIGYYKPSKIIANRITSLARASLSELLKDTPNYKSIFKSSLDIYHVVIDVNINKLPMYRESNLTKYKNLQNMSSERPGFEPITEFVKELHRCFEDTISFFYNKKNPKVVTGVFNPRILANRPYRTNIDYPFKVVDKDTVVLDADVVCEEIRQVGGDLIRSIQLQLKA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	GLKREHESSSSQDGS CCCCCCCCCCCCCCC	37.11	29996109
11	Phosphorylation	LKREHESSSSQDGSK CCCCCCCCCCCCCCC	30.90	21712547
12	Phosphorylation	KREHESSSSQDGSKT CCCCCCCCCCCCCCC	41.10	29996109
13	Phosphorylation	REHESSSSQDGSKTP CCCCCCCCCCCCCCC	33.95	21712547
17	Phosphorylation	SSSSQDGSKTPETEY CCCCCCCCCCCCCHH	41.46	21712547
19	Phosphorylation	SSQDGSKTPETEYDS CCCCCCCCCCCHHHH	28.23	24763107
22	Phosphorylation	DGSKTPETEYDSHVD CCCCCCCCHHHHCCC	40.84	21712547
24	Phosphorylation	SKTPETEYDSHVDSI CCCCCCHHHHCCCCH	30.11	21712547
30	Phosphorylation	EYDSHVDSIEDIHSL HHHHCCCCHHHHHHH	27.13	21712547
378	Phosphorylation	SSKNLTSTLFKLNAD CCCCCCHHHHEECCC	30.86	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UTP22_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UTP22_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UTP22_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of UTP22_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UTP22_SCHPO

Related Literatures of Post-Translational Modification