UTP18_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UTP18_DROME
• UniProt AC: Q9V7P1
• Protein Name: U3 small nucleolar RNA-associated protein 18 homolog
• Gene Name: wcd
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 506
• Subcellular Localization: Nucleus, nucleolus . Asymmetric segregation of expression upon mitosis both in germline stem cells (GSCs) and dividing larval neural stem cells (NSCs) (at protein level).
• Protein Description: Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA. Regulation of cell size by ribosome synthesis is an important parameter for stem cell maintenance and function..
• Protein Sequence: MSSDESSDGLEELQSLKALYGQQEQEKPAKIKRERYIPKASQAKELNYVEVPMEKVLFGDRQRLLTNLAKSVGQKLPNDDEDEQEENPGQAKPGDKRKAAWSDSDDEDLQVGDVKKATKHTGPLNHLRKDKSYKEYLTARFQRTLNQPKWAEKKVKNEDDEDVSSDEELLRTVGFIDRKARNSDLPQKTLNFKRVKDLNRATYAEGNATSIQFHPTSTAALVAGMNGLATIYAVDGQKNERLHNMRFKKFPLACSRIAPCGTRAFFGSVKPFYYSYDLLEAKESKLKLPGAMEFMHRFEVSPCGKFIVTAGKFGAIHLLTAKTNELLHSFKQEGKVKGFTWSSDSKRILVCGSTSNVSVLNLRQNLIEHIFMDDGCIHGESIQLSPNQRLLATGSQEGVVNIYDYESIFASKAPQPEKRFMNLRTAITDLQFNHSSELLAMCSSEAPNAFKLAHFPSATVYSNFPAQNEKVGFVTSMAFSPHSSFLAFATKGKQVPLFRLKYFKGY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSDESSDG ------CCCCCCCHH	46.63	19429919
3	Phosphorylation	-----MSSDESSDGL -----CCCCCCCHHH	44.06	19429919
6	Phosphorylation	--MSSDESSDGLEEL --CCCCCCCHHHHHH	38.43	19429919
7	Phosphorylation	-MSSDESSDGLEELQ -CCCCCCCHHHHHHH	33.38	19429919
102	Phosphorylation	DKRKAAWSDSDDEDL CCCCCCCCCCCCCCC	23.62	21082442
104	Phosphorylation	RKAAWSDSDDEDLQV CCCCCCCCCCCCCCC	41.25	21082442
164	Phosphorylation	NEDDEDVSSDEELLR CCCCCCCCCHHHHHH	44.38	21082442
165	Phosphorylation	EDDEDVSSDEELLRT CCCCCCCCHHHHHHH	49.22	21082442
183	Phosphorylation	IDRKARNSDLPQKTL HCHHHCCCCCCCCCC	34.66	27626673

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UTP18_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UTP18_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UTP18_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of UTP18_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-102; SER-104; SER-164AND SER-165, AND MASS SPECTROMETRY.
PubMed: 18327897