dbPTM

USPL1_DANRE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	USPL1_DANRE
UniProt AC	Q6DRC5
Protein Name	SUMO-specific isopeptidase USPL1
Gene Name	uspl1
Organism	Danio rerio (Zebrafish) (Brachydanio rerio).
Sequence Length	1014
Subcellular Localization	Nucleus, Cajal body .
Protein Description	SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for sumo2 and sumo3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms. [PubMed: 22878415 Plays a key role in RNA polymerase-II-mediated snRNA transcription in the Cajal bodies (By similarity Is a component of complexes that can bind to U snRNA genes (By similarity]
Protein Sequence	MNGEGTGIGAPTPALAGFLGKSKDRNASPGNCPWCLAKGQTNALRFYAVNLKETVLLCTNAVCLYPLVSRSLEEVRASLSKGGCKRSISSLPDISDDSCPPKRPREEKLDVLADVSEPCDAEVNDATLPDDTVKTQTFTDQQSAPAETISLDKTEEQPVSIEDIKEQPISHDATEGQPISIDQTEEQPVSILHTEEQPIVLDLIEVKPMSVDHSEEQPICIDNTKERPVSIVHTEEQSIVLDLFEVKPMSIAHTEEKPTSFDHIEEKPMSIAHTEEKPVSLVHTEDQHLSIDQTEEQPISIDPTEEQQPEELPAVSDEDVDLCERKEDCVSSTQDEMEEEVLESSSELVPVHSELFWKNEENMCWLDAMLVMLVHCRTIRGTPCRGIKLSDKLATVPCNDSVVWKLCWRYDKTCAYLQARKKQSEDKVLRVPAGVLVEAERRLSALRLSVFKLLQPTLKCEIGQQETPVFALPLLLRSDKWAQDIFQHTIRWEFKCTCCDFTVNESVEKTLTTLTCIVKDWHPLKANNRTQCNKCEHKNQRRKMVLEKLSSVFALHFVEGLPRKDLTKYGFTFQGFQYSVSTIIQYNKHLQHFVTWVRQSNGFWLELDDLKHPYSPTHKRLPFPSSEFHILFWETDSFKEEHSEVCLPTAPPEVPNAPDEHPPKLSDSVATDTCVISALTVEDTTASSIADTSIGSTTLLDTFEGLTHKDIVTLTLVNSESPKNEPRPMRPGFVSAPRHCPFEASNLLSGIPKTGSRLSTPPIPQKSSLVHKPEVAAAAVSKTHLQPTSLFQRHPSFQSTPIRPPPPLPPAPKPKPSLQYDKHEDLPVKPADMFGGFKTKKLANSQPKQISLPGGLNPSVKKTAGQEPISTTEALRLKLMKKLKAKKKKLAKLNQLLGNGGESVAKPDSTALSSPYSVTSSTTTYDSFDDQFLADLLSPATTVSNLSPDSTGLLEMLNNGQNGEQQNPAVATLAPEATLTCSSSTISPLDEYMQSGMCHTALENADFNSLDIFF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of USPL1_DANRE !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of USPL1_DANRE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of USPL1_DANRE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of USPL1_DANRE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
RAGP1_HUMAN	RANGAP1	physical	22878415
SUMO3_HUMAN	SUMO3	physical	22878415

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of USPL1_DANRE

Related Literatures of Post-Translational Modification