UPL3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UPL3_ARATH
• UniProt AC: Q6WWW4
• Protein Name: E3 ubiquitin-protein ligase UPL3
• Gene Name: UPL3
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1888
• Protein Description: Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the repression of endoreduplication process and the cell morphogenesis in the trichomes..
• Protein Sequence: METRSRKRAEATSAAPSSSSSSPPPPPSASGPTTRSKRARLSSSSSSSLAPTPPSSSTTTRSRSSRSAAAAAPMDTSTDSSGFRRGGRGNRGNNNDNSDKGKEKEHDVRIRERERERDRAREQLNMDAAAAAARSADEDDDNDSEDGNGGFMHPNMSSASSALQGLLRKLGAGLDDLLPSSGIGSASSSHLNGRMKKILSGLRAEGEEGKQVEALTQLCEMLSIGTEDSLSTFSVDSFVPVLVGLLNHESNPDIMLLAARALTHLCDVLPSSCAAVVHYGAVSCLVARLLTIEYMDLAEQSLQALKKISQEHPTACLRAGALMAVLSYLDFFSTGVQRVALSTAANMCKKLPSDASDYVMEAVPLLTNLLQYHDSKVLEYASICLTRIAEAFAPYPEKLDELCNHGLVTQAASLISTSNSGGGQASLSVSTYTGLIRLLSTCASGSPLGFRTLLLLGISSILKDILLGSGVSANASVSPALSRPADQIYEIVNLANELLPPLPEGVISLPTSTNALVKGSCQKKSSPSTSGKQEDILKISPREKLLGDQPELLQQFGLDLLPVLVQIYGSSVNGTIRHKCLSVIGKLMYFSSSEMIQSLIGDTNISSFLAGVLAWKDPQVLVPALQVAEILMEKLPETFSKVFVREGVVHAVDQLVLVGKPSHASPTDKDNDCVPGSARSRRYRRRSSNANSDGNQSEEPKNPASLTIGANHNSLDTPTASFMLRETVSSCAKAFKDKYFPSDGGDVDVGVTDDLLHLKNLCTKLTAGIDDHKVKGKGKSKASGPFLGDFSASKEEYLIGVISEILGEISKGDGVSTFEFIGSGVVAALLNYFSCGYFSKEKISELNLPKLRQEGLRRFKAFLEVALPFDGNEGKVPPMTVLIQKLQNALSSLERFPVVLSHPSRSLSGSARLSSGLSALAHPLKLRLCRASGEKTLRDYSSNIVLIDPLASLAAVEEFLWPRVQRSESALKPAAPIGNTEPGTLPSGAGVSSPSSSTPASTTRRHSSRSRSAINIGDTSKKDPVHEKGTSSSKGKGKGVMKPAQADKGPQTRSNAQKRAVLDKDTQMKPASGDSSSEDEELEISPVDIDDALVIEEDDISDDEDDDNEDVLDDSLPMCTPDKVHDVKLADSVDDDGLATSGRQMNPASGGTSGAAAARASDSIDTGIGNSYGSRGALSFAAAAMAGLGAASGRGIRGSRDLHGRTLNRSSDEPSKLIFTAAGKQLSRHLTIYQAVQRQLMLDEDDDDRFGGSDLVSSDGSRFNDIYTIMYQRPDSQVNRLSVGGASSTTPSKSTKSATTNSSVESQSHRASLLDSILQGELPCDLEKSNSTYNVLALLRVLEGLNQLCPRLRAQTLSDRFAEGKITSLDDLSTTAAKVPLDEFVNSKLTPKLARQIQDALALCSGSLPSWCYQLTRACPFLFPFQTRRQYFYSTAFGLSRALNRLQQQQGADGSGSTNEREMRIGRLQRQKVRVSRNRILDSAAKVMEMYSSQKAVLEVEYFGEVGTGLGPTLEFYTLLSHDLQKASLGMWRSSSGDKVSMQIGRDEIEDGKPSAANRDIVLAPLGLFPRPWPSTADISEGGQFHKVIEYFRLLGRVMAKALQDGRLLDVPLSTAFYKLILGQELDLHDIVLFDAELGKTLQELRVVVARKHYLEGVGGDNSSTISDLCLRGCRIEDLSLEFTLPGYPEYILRSGDEIVDITNLEEYISLVVDATVKRGVTRQIEAFRSGFNQVFDITSLQIFTPSELDYLLCGRRELWEVETLAEHIKFDHGYNAKSPAIINLLEIMGELTADQQRAFCQFVTGAPRLPPGGLAVLNPKLTIVRKHSSTSSAAANGAGASETADDDLPSVMTCANYLKLPPYSTKEIMYKKLLYAINEGQGSFDLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	RKRAEATSAAPSSSS HHHHHCCCCCCCCCC	29.49	25561503
17	Phosphorylation	EATSAAPSSSSSSPP HCCCCCCCCCCCCCC	37.82	25561503
18	Phosphorylation	ATSAAPSSSSSSPPP CCCCCCCCCCCCCCC	32.93	29654922
19	Phosphorylation	TSAAPSSSSSSPPPP CCCCCCCCCCCCCCC	38.28	29654922
20	Phosphorylation	SAAPSSSSSSPPPPP CCCCCCCCCCCCCCC	36.46	29654922
21	Phosphorylation	AAPSSSSSSPPPPPS CCCCCCCCCCCCCCC	49.14	27532006
22	Phosphorylation	APSSSSSSPPPPPSA CCCCCCCCCCCCCCC	43.29	27532006
44	Phosphorylation	KRARLSSSSSSSLAP HCCCCCCCCCCCCCC	30.75	29654922
45	Phosphorylation	RARLSSSSSSSLAPT CCCCCCCCCCCCCCC	35.87	29654922
46	Phosphorylation	ARLSSSSSSSLAPTP CCCCCCCCCCCCCCC	26.37	29654922
47	Phosphorylation	RLSSSSSSSLAPTPP CCCCCCCCCCCCCCC	31.17	29654922
48	Phosphorylation	LSSSSSSSLAPTPPS CCCCCCCCCCCCCCC	30.42	22074104
52	Phosphorylation	SSSSLAPTPPSSSTT CCCCCCCCCCCCCCC	42.07	22074104
55	Phosphorylation	SLAPTPPSSSTTTRS CCCCCCCCCCCCCCC	37.82	22074104
56	Phosphorylation	LAPTPPSSSTTTRSR CCCCCCCCCCCCCCC	37.16	22074104
57	Phosphorylation	APTPPSSSTTTRSRS CCCCCCCCCCCCCCH	33.83	22074104
58	Phosphorylation	PTPPSSSTTTRSRSS CCCCCCCCCCCCCHH	33.85	22074104
59	Phosphorylation	TPPSSSTTTRSRSSR CCCCCCCCCCCCHHC	23.35	22074104
60	Phosphorylation	PPSSSTTTRSRSSRS CCCCCCCCCCCHHCC	27.08	22074104
62	Phosphorylation	SSSTTTRSRSSRSAA CCCCCCCCCHHCCCH	34.13	22074104
67	Phosphorylation	TRSRSSRSAAAAAPM CCCCHHCCCHHHCCC	24.98	25561503
76	Phosphorylation	AAAAPMDTSTDSSGF HHHCCCCCCCCCCCC	27.55	29654922
77	Phosphorylation	AAAPMDTSTDSSGFR HHCCCCCCCCCCCCC	26.42	30407730
78	Phosphorylation	AAPMDTSTDSSGFRR HCCCCCCCCCCCCCC	41.83	29654922
80	Phosphorylation	PMDTSTDSSGFRRGG CCCCCCCCCCCCCCC	32.23	30407730
81	Phosphorylation	MDTSTDSSGFRRGGR CCCCCCCCCCCCCCC	44.77	30407730
135	Phosphorylation	AAAAAARSADEDDDN HHHHHHHHCCCCCCC	35.03	29654922
144	Phosphorylation	DEDDDNDSEDGNGGF CCCCCCCCCCCCCCC	43.79	29654922
525	Phosphorylation	KGSCQKKSSPSTSGK CCCCCCCCCCCCCCC	55.29	23776212
526	Phosphorylation	GSCQKKSSPSTSGKQ CCCCCCCCCCCCCCH	31.58	23776212
528	Phosphorylation	CQKKSSPSTSGKQED CCCCCCCCCCCCHHH	36.83	23776212
529	Phosphorylation	QKKSSPSTSGKQEDI CCCCCCCCCCCHHHH	44.90	23776212
530	Phosphorylation	KKSSPSTSGKQEDIL CCCCCCCCCCHHHHH	48.62	23776212
665	Phosphorylation	VGKPSHASPTDKDND CCCCCCCCCCCCCCC	23.94	25561503
688	Phosphorylation	RRYRRRSSNANSDGN HHHHHHCCCCCCCCC	37.84	25561503
906	Phosphorylation	VLSHPSRSLSGSARL ECCCCCCCCCCCCCH	31.09	28011693
908	Phosphorylation	SHPSRSLSGSARLSS CCCCCCCCCCCCHHH	31.76	28011693
910	Phosphorylation	PSRSLSGSARLSSGL CCCCCCCCCCHHHHH	13.57	28011693
914	Phosphorylation	LSGSARLSSGLSALA CCCCCCHHHHHHHHH	19.46	25561503
915	Phosphorylation	SGSARLSSGLSALAH CCCCCHHHHHHHHHH	48.63	25561503
918	Phosphorylation	ARLSSGLSALAHPLK CCHHHHHHHHHHHHH	25.43	25561503
987	Phosphorylation	TEPGTLPSGAGVSSP CCCCCCCCCCCCCCC	44.37	27288362
992	Phosphorylation	LPSGAGVSSPSSSTP CCCCCCCCCCCCCCC	35.30	17317660
993	Phosphorylation	PSGAGVSSPSSSTPA CCCCCCCCCCCCCCC	26.79	27288362
995	Phosphorylation	GAGVSSPSSSTPAST CCCCCCCCCCCCCCC	38.58	27288362
996	Phosphorylation	AGVSSPSSSTPASTT CCCCCCCCCCCCCCC	41.43	27288362
997	Phosphorylation	GVSSPSSSTPASTTR CCCCCCCCCCCCCCC	42.63	27288362
998	Phosphorylation	VSSPSSSTPASTTRR CCCCCCCCCCCCCCC	25.48	27288362
1001	Phosphorylation	PSSSTPASTTRRHSS CCCCCCCCCCCCCCC	31.36	27288362
1010	Phosphorylation	TRRHSSRSRSAINIG CCCCCCCCCCCEECC	32.32	25561503
1012	Phosphorylation	RHSSRSRSAINIGDT CCCCCCCCCEECCCC	34.44	23111157
1132	Phosphorylation	HDVKLADSVDDDGLA CEEEECCCCCCCCCC	23.10	30291188
1140	Phosphorylation	VDDDGLATSGRQMNP CCCCCCCCCCCCCCC	36.44	25561503
1141	Phosphorylation	DDDGLATSGRQMNPA CCCCCCCCCCCCCCC	26.77	23111157
1171	Phosphorylation	IDTGIGNSYGSRGAL CCCCCCCCCCHHHHH	26.17	17317660
1172	Phosphorylation	DTGIGNSYGSRGALS CCCCCCCCCHHHHHH	24.10	25561503
1174	Phosphorylation	GIGNSYGSRGALSFA CCCCCCCHHHHHHHH	21.22	25561503
1179	Phosphorylation	YGSRGALSFAAAAMA CCHHHHHHHHHHHHH	16.59	30291188
1192	Phosphorylation	MAGLGAASGRGIRGS HHHCCHHCCCCCCCC	28.61	30407730
1227	Phosphorylation	TAAGKQLSRHLTIYQ EHHHHHHHHHHHHHH	18.37	19880383
1257	Phosphorylation	FGGSDLVSSDGSRFN CCCCCCCCCCCCCCC	29.97	25561503
1282	Phosphorylation	DSQVNRLSVGGASST CCCCCEEEECCCCCC	18.58	25561503
1288	Phosphorylation	LSVGGASSTTPSKST EEECCCCCCCCCCCC	35.45	23328941
1289	Phosphorylation	SVGGASSTTPSKSTK EECCCCCCCCCCCCC	39.98	22631563
1290	Phosphorylation	VGGASSTTPSKSTKS ECCCCCCCCCCCCCC	27.75	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UPL3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UPL3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UPL3_ARATH !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GL3_ARATH	GL3	physical	23373825
EGL1_ARATH	EGL3	physical	23373825

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.