UPL2_ARATH - dbPTM
UPL2_ARATH - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UPL2_ARATH
UniProt AC Q8H0T4
Protein Name E3 ubiquitin-protein ligase UPL2
Gene Name UPL2
Organism Arabidopsis thaliana (Mouse-ear cress).
Sequence Length 3658
Subcellular Localization
Protein Description Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins..
Protein Sequence MKLRRRRASEVPTKISLFINSVTSVPLELIQEPLASFRWEFDKGDFHHWVDLFYHFDTFFEKHVKVRKDLRIEEEFDESDPPFPKDAVLQVLRVIRLVLENCTNKQFYTSYEQHLSLLLASTDADVVEACLQTLAAFLKRPTGKYSIRDASLNLKLFSLAQGWGGKEEGLGLTSCATEHSCDQLFLQLGCTLLFEFYASDESPSELPGGLQVIHVPDVSMRSESDLELLNKLVIDHNVPPSLRFALLTRLRFARAFSSLATRQQYTCIRLYAFIVLVQASGDTENVVSFFNGEPEFVNELVTLVSYEDTVPAKIRILCLQSLVALSQDRTRQPTVLTAVTSGGHRGLLSGLMQKAIDSVICNTSKWSLAFAEALLSLVTVLVSSSSGCSAMREAGLIPTLVPLIKDTDPQHLHLVSTAVHILEVFMDYSNPAAALFRDLGGLDDTIFRLKQEVSRTEDDVKEIVCCSGSNGPEDDTEQLPYSEALISYHRRLLLKALLRAISLGTYAPGNTNLYGSEESLLPECLCIIFRRAKDFGGGVFSLAATVMSDLIHKDPTCFNALDSAGLTSAFLDAISDEVICSAEAITCIPQCLDALCLNNSGLQAVKDRNALRCFVKIFSSPSYLKALTSDTPGSLSSGLDELLRHQSSLRTYGVDMFIEILNSILIIGSGMEATTSKSADVPTDAAPVPMEIDVDEKSLAVSDEAEPSSDTSPANIELFLPDCVCNVARLFETVLQNAEVCSLFVEKKGIDTVLQLFSLPLMPLSTSLGQSFSVAFKNFSPQHSAGLARILCSYLREHLKKTNNLLVSIEGTQLLKLESAVQTKILRSLSCLEGMLSLSNFLLKGSASVISELSAANADVLKELGITYKQTIWQMALCNDTKEDEKKSVDRASDNSVSASSSTAERESDEDSSNALAVRYTNPVSIRSSSSQSIWGGHREFLSVVRSGRGVHGHTRHAIARMRGGRTRRHLESFNFDSEIPADLPVTSSSHELKKKSTEVLIAEILNKLNCTLRFFFTSLVKGFTSANRRRIDGPSLSSASKTLGTALAKVFLEALNFQGYGAAAGPDTSLSLKCRYLGKVVDDITFLTFDTRRRVCFTAMVNSFYVHGTFKELLTTFEATSQLLWKVPFSIRASSTENEKSGERNLWSHSKWLVDTLQNYCRALDYFVNSTYLLSPTSQTQLLVQPASVDLSIGLFPVPREPETFVRNLQSQVLEVILPIWNHPMFPDCNPNFVASVTSLVTHIYSGVVDTRENRSGATQGTNQRALPLQPDEAIVGMIVEMGFSRSRAEDALRRVGTNSVEMAMDWLFTNPEDPVQEDDELAQALALSLGNSSETPKLEDTEKPVDVPQEEAEPKEPPVDEVIAASVKLFQSDDSIAFPLVDLFVTLCNRNKGEDRPKIVFYLIQQLKLVQLDFSKDTGALTMIPHILALVLSEDDNTREIAAQDGIVAVAIGILTDFNLKSESETDILAPKCISALLLVLSMMLQAQTRLSSEYVEGNQGGSLVLSDSPQDSTAALKDALSSDVAKGESNQALESMFGKSTGYLTMEESSKVLLIACGLIKQRVPAMIMQAVLQLCARLTKSHALAIQFLENGGLSSLFNLPKKCFFPGYDTVASVIVRHLVEDPQTLQIAMETEIRQTLSGKRHIGRVLPRTFLTTMAPVISRDPVVFMKAVASTCQLESSGGTDFVILTKEKEKPKVSGSEHGFSLNEPLGISENKLHDGSGKCSKSHRRVPTNFIQVIDQLIDIVLSFPGLKRQEGEAANLISMDVDEPTTKVKGKSKVGEPEKAELGSEKSEELARVTFILKLLSDIVLMYLHGTSVILRRDTEISQLRGSNLPDDSPGNGGLIYHVIHRLLPISLEKFVGPEEWKEKLSEKASWFLVVLCSRSNEGRKRIINELTRVLSVFASLGRSSSQSVLLPDKRVLAFANLVYSILTKNSSSSNFPGCGCSPDVAKSMIDGGTIQCLTSILNVIDLDHPDAPKLVTLILKSLETLTRAANAAEQLKSEVPNEQKNTDSDERHDSHGTSTSTEVDELNQNNSSLQQVTDAVDNGQEQPQVSSQSEGERGSSLTQAMLQEMRIEGDETILPEPIQMDFFREEIEGDQIEMSFHVEDRADDDVDDDMDDEGEDDEGDDEDADSVEDGAGVMSIAGTDVEDPEDTGLGDEYNDDMVDEDEEDEDEYNDDMVDEDEDDEDEYNDDMVDEDEDDFHETRVIEVRWREALDGLDHFQIVGRSGGGNGFIDDITAEPFEGVNVDDLFALRRSLGFERRRQTGRSSFDRSGSEVHGFQHPLFSRPSQTGNTASVSASAGSISRHSEAGSYDVAQFYMFDSPVLPFDQVPVDPFSDRLGGGGAPPPLTDYSVVGMDSSRRGVGDSRWTDVGHPQPSSLSASIAQLIEEHFITNLRASAPVDTVVERETNTTEVQEQQQPDVPPSVGSETVLGDGNEGGEQSEEHELLNNNEVMHPLPLNSTPNEIDRMEVGEGGGAPIEQVDREAVHLISSAQGQSDTSGIQNVSVTAIPPPVDDPDSNFQPSVDVDMSSDGAEGNQSVQPSPLDGDNNELSSMEATQDVRNDEQVDEGSLDGRAPEVNAIDPTFLEALPEDLRAEVLASQQAQSVQPPTYEPPSVDDIDPEFLAALPPEIQREVLAQQRAQRMLQQSQGQPVDMDNASIIATLPADLREEVLLTSSEAVLAALPPPLLAEAQMLRDRAMRHYQARSRVFGSSHRLNNRRNGLGYRLTGMERGVGVTIGQRDVSSSADGLKVKEIEGDPLVNADALKSLIRLLRLAQPLGKGLLQRLLLNLCAHSFTRANLVQLLLDMIRPEMETLPSELALTNPQRLYGCQLNVVYGRSQLLNGLPPLVFRRVLEVLTYLATNHSAVADMLFYFDSSLLSQLSSRKGKEKVTHETDSRDLEIPLVVFLKLLNRPQLLQSTSHLALVMGLLQVVVYTAASRIEGWSPSSGVPEKLENKPVGEEASSETQKDAESELSVARRKNCAELYNIFLQLPQSDLCNLCMLLGYEGLSDKIYSLAGEVLKKLAAVDVTHRKFFTKELSELASGLSSSTVRVLATLSTTQKMSQNTCSMAGASILRVLQVLSSLTSTIDDSNVGTDKETDQEEQNIMQGLKVALEPLWQELGQCISMTELQLDHTAATSNVNPGDHVLGISPTSSLSPGTQSLLPLIEAFFVLCEKIQTPSMLQQDATVTAGEVKESSTHGSSSKTIVDSQKKIDGSVTFSKFVEKHRRLLNSFVRQNPSLLEKSFSMMLKAPRLIDFDNKKAYFRSRIRHQHDQHISGPLRISVRRAYVLEDSYNQLRMRSPQDLKGRLNVQFQGEEGIDAGGLTREWYQLLSRVIFDKGALLFTTVGNDATFQPNPNSVYQTEHLSYFKFVGRMVAKALFDGQLLDVYFTRSFYKHILGVKVTYHDIEAVDPDYYKNLKWLLENDVSDILDLTFSMDADEEKHILYEKTEVTDYELKPGGRNIRVTEETKHEYVDLVADHILTSAIRPQINAFLEGLNELIPRELVSIFNDKELELLISGLPEIDFDDLKANTEYTSYTVGSPVIRWFWEVVKAFSKEDMARFLQFVTGTSKVPLEGFKALQGISGPQRLQIHKAYGSPERLPSAHTCFNQLDLPEYQSKEQVQERLLLAIHEANEGFGFA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
9PhosphorylationKLRRRRASEVPTKIS
CCCCCCHHCCCCCHH		37.0025561503
108PhosphorylationNCTNKQFYTSYEQHL
CCCCCCCCCCHHHHH		7.7125368622
109PhosphorylationCTNKQFYTSYEQHLS
CCCCCCCCCHHHHHH		26.5625368622
110PhosphorylationTNKQFYTSYEQHLSL
CCCCCCCCHHHHHHH		18.4525368622
111PhosphorylationNKQFYTSYEQHLSLL
CCCCCCCHHHHHHHH		16.2925368622
116PhosphorylationTSYEQHLSLLLASTD
CCHHHHHHHHHHCCC		18.1725368622
121PhosphorylationHLSLLLASTDADVVE
HHHHHHHCCCHHHHH		27.1325368622
122PhosphorylationLSLLLASTDADVVEA
HHHHHHCCCHHHHHH		29.6025368622
133PhosphorylationVVEACLQTLAAFLKR
HHHHHHHHHHHHHCC		12.8625368622
142PhosphorylationAAFLKRPTGKYSIRD
HHHHCCCCCCCCHHH		50.7925368622
846PhosphorylationSNFLLKGSASVISEL
HHHHHCCCHHHHHHH		18.7819880383
848PhosphorylationFLLKGSASVISELSA
HHHCCCHHHHHHHHH		22.9819880383
867PhosphorylationVLKELGITYKQTIWQ
HHHHHCCCHHHHHHH		23.9119880383
868PhosphorylationLKELGITYKQTIWQM
HHHHCCCHHHHHHHH		10.1219880383
893PhosphorylationKKSVDRASDNSVSAS
HHHHCCCCCCCCCCC		37.9123776212
896PhosphorylationVDRASDNSVSASSST
HCCCCCCCCCCCCCC		23.5723776212
898PhosphorylationRASDNSVSASSSTAE
CCCCCCCCCCCCCCC		23.4323776212
900PhosphorylationSDNSVSASSSTAERE
CCCCCCCCCCCCCCC		19.8123776212
901PhosphorylationDNSVSASSSTAERES
CCCCCCCCCCCCCCC		31.2723776212
902PhosphorylationNSVSASSSTAERESD
CCCCCCCCCCCCCCC		29.1923776212
903PhosphorylationSVSASSSTAERESDE
CCCCCCCCCCCCCCC		34.1923776212
908PhosphorylationSSTAERESDEDSSNA
CCCCCCCCCCCCCCC		53.1523776212
912PhosphorylationERESDEDSSNALAVR
CCCCCCCCCCCEEEE		24.3623776212
913PhosphorylationRESDEDSSNALAVRY
CCCCCCCCCCEEEEE		38.1423776212
987PhosphorylationIPADLPVTSSSHELK
CCCCCCCCCCCHHHH		22.4323776212
988PhosphorylationPADLPVTSSSHELKK
CCCCCCCCCCHHHHH		30.0323776212
989PhosphorylationADLPVTSSSHELKKK
CCCCCCCCCHHHHHC		26.7523776212
990PhosphorylationDLPVTSSSHELKKKS
CCCCCCCCHHHHHCC		22.2823776212
1072PhosphorylationAGPDTSLSLKCRYLG
CCCCCCHHHHHHHHC		26.0828011693
1516PhosphorylationSDSPQDSTAALKDAL
CCCCCCCHHHHHHHH		25.0023660473
1524PhosphorylationAALKDALSSDVAKGE
HHHHHHHCCCHHCCC		26.6425561503
1525PhosphorylationALKDALSSDVAKGES
HHHHHHCCCHHCCCH		36.6325561503
1703PhosphorylationEKEKPKVSGSEHGFS
CCCCCCCCCCCCCCC		42.6024601666
1705PhosphorylationEKPKVSGSEHGFSLN
CCCCCCCCCCCCCCC		20.9324601666
1710PhosphorylationSGSEHGFSLNEPLGI
CCCCCCCCCCCCCCC		34.5723776212
2018PhosphorylationVPNEQKNTDSDERHD
CCCCCCCCCCCCCCC		43.8729654922
2071PhosphorylationQSEGERGSSLTQAML
CCCCCCCCHHHHHHH		28.5324243849
2072PhosphorylationSEGERGSSLTQAMLQ
CCCCCCCHHHHHHHH		37.9624243849
2283PhosphorylationGRSSFDRSGSEVHGF
CCCCCCCCCCCCCCC		48.8125561503
2285PhosphorylationSSFDRSGSEVHGFQH
CCCCCCCCCCCCCCC		37.3829654922
2308PhosphorylationTGNTASVSASAGSIS
CCCCCEEEECCCCCC		17.6325561503
2310PhosphorylationNTASVSASAGSISRH
CCCEEEECCCCCCCC		26.1729654922
2313PhosphorylationSVSASAGSISRHSEA
EEEECCCCCCCCCCC		19.6725561503
2315PhosphorylationSASAGSISRHSEAGS
EECCCCCCCCCCCCC		26.1525561503
2318PhosphorylationAGSISRHSEAGSYDV
CCCCCCCCCCCCCCE		28.2129654922
2582PhosphorylationDEQVDEGSLDGRAPE
HHHCCCCCCCCCCCC		22.6530291188
2596PhosphorylationEVNAIDPTFLEALPE
CCCCCCHHHHHHCCH		36.7823776212
2724PhosphorylationARSRVFGSSHRLNNR
HHHHHHCCCHHCCCC		16.1129654922
2725PhosphorylationRSRVFGSSHRLNNRR
HHHHHCCCHHCCCCC		17.0129654922
2756PhosphorylationTIGQRDVSSSADGLK
EECCCCCCCCCCCCE		23.9025561503
2757PhosphorylationIGQRDVSSSADGLKV
ECCCCCCCCCCCCEE		29.4125561503
2758PhosphorylationGQRDVSSSADGLKVK
CCCCCCCCCCCCEEE		23.9130407730
2986PhosphorylationETQKDAESELSVARR
HHHHHHHHHHHHHHH		45.6219880383
2989PhosphorylationKDAESELSVARRKNC
HHHHHHHHHHHHHCH		15.0719880383
3212PhosphorylationTAGEVKESSTHGSSS
EHHEEECCCCCCCCC		34.5224601666
3213PhosphorylationAGEVKESSTHGSSSK
HHEEECCCCCCCCCC		26.0524601666
3214PhosphorylationGEVKESSTHGSSSKT
HEEECCCCCCCCCCE		39.2624601666
3217PhosphorylationKESSTHGSSSKTIVD
ECCCCCCCCCCEEEC		24.6724601666
3218PhosphorylationESSTHGSSSKTIVDS
CCCCCCCCCCEEECC		40.2124601666
3219PhosphorylationSSTHGSSSKTIVDSQ
CCCCCCCCCEEECCC		35.2024601666
3317PhosphorylationYNQLRMRSPQDLKGR
CHHHHCCCCCHHCCC		19.9825561503
3602PhosphorylationFKALQGISGPQRLQI
HHHHCCCCCCCHHHH		51.7729654922
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UPL2_ARATH !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UPL2_ARATH !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UPL2_ARATH !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
UNE12_ARATHUNE12physical
21798944
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UPL2_ARATH

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2582, AND MASSSPECTROMETRY.
"Site-specific phosphorylation profiling of Arabidopsis proteins bymass spectrometry and peptide chip analysis.";
de la Fuente van Bentem S., Anrather D., Dohnal I., Roitinger E.,Csaszar E., Joore J., Buijnink J., Carreri A., Forzani C.,Lorkovic Z.J., Barta A., Lecourieux D., Verhounig A., Jonak C.,Hirt H.;
J. Proteome Res. 7:2458-2470(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2582, AND MASSSPECTROMETRY.

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