UPL1_ARATH - dbPTM
UPL1_ARATH - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UPL1_ARATH
UniProt AC Q8GY23
Protein Name E3 ubiquitin-protein ligase UPL1
Gene Name UPL1
Organism Arabidopsis thaliana (Mouse-ear cress).
Sequence Length 3681
Subcellular Localization
Protein Description Probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins..
Protein Sequence MKLRRRRASEVPSKIKSFINSVTSVPLELIHEPLACFRWEFDKGDFHHWVDLFNYFDTFFEKHVQVRKDLHIEENFEESDPPFPKDAVLQVLRVIRVVLENCTNKHFYSSYEQHLSLLLASTDADVVEACLQTLAAFLKRQIGKYSIRDASLNSKLFSLAQGWGGKEEGLGLTSCAAENSCDQVSLQLGRTLHFEFYPSDESPSELPGGLQVIHVPDVSICAESDLELLNKLVIDHNVPPSLRFALLTRMRFARAFSSLATRQQFTCIRLYAFVVLVQASGDTENVVSFFNGEPEFVNELVTLVSYEDTVPEKIRILCLLSLVALSQDRTRQPTVLTAVTSGGHRGLLSGLMQKAIDSVVCITSKWSLAFAEALLSLVTVLVSSSSGCSAMREAGLIPTLVPLIKDTDPQHLHLVSAAVHILEAFMDYSNPAAALFRDLGGLDDTIFRLKLEVSRTEDDVKEKNCSSDSNGPDTEQLPYSEALISYHRRLLLKALLRAISLGTYAPGNTNLYGSEESLLPECLCIIFRRAKDFGGGVFSLAATVMSDLIHKDPTCFNALDSAGLTSTFLDAISDEVICSAEAITCIPQCLDALCLNNSGLQAVKDRNALRCFVKIFTSPSYLRALTGDTPGSLSSGLDELLRHQSSLRTYGVDMFIEILNSMLIIGSGMEATTSKSADVPTSAAPVPMEIDVDEKSLAVSDEAEPSSDTSPANIELFLPDCVCNVARLFETVLQNAEVCSLFVEKKGIDAVLQLFSLPLMPLSTSLGQSFSVAFKNFSPQHSAGLARIVCSYLREHLKKTKILLVSIEGTQLLKLESAIQTKILRSLSCLEGMLSLSNFLLKGSASVISELSAADADVLKELGITYKQTIWQMALCNDTKEDEKKSVDRGSDNSVSASSSTAERESDEDSSNALAVRYTNPVSIRSSSSQSIWGGDREFLSIVRSGEGIHGRTRHAIARMRGGRTRRHLESFNFDSEIPADLPVTSSSHELKKKSTEVLIAEILNKLNCTLRFFFTALVKGFTSANRRRIDGASLSSASKTLGTALAKVFLEALNFDGYGAAAGHEKSLSVKCRYLGKVVDDITFLSFDTRRRVCFTAMVNSFYVHGTFKELLTTFEATSQLLWTVPFSIPASSTENEKPGERNIWSHSKWLVDTLQNYCRALDYFVNSTYLLSPTSQTQLLVQPASVGLSIGLFPVPREPETFVRNLQSQVLDVILPIWNHPMFPDCNPNFVASVTSLVTHIYSGVVDARENRSGVTRGINQRALPLQLDESIVGMIVEMGFSRSRAEIALRRVGTNSVEMAMDWLFTNPEQPVQEDDELAQALALSLGNSSETPKLEDTEKPVDVPQEEAEPKEPPVDEVIAASVKLFQSDDSMAFPLMDLFVTLCNRNKGEDRPKIVSYLIQQLKLVQLDFSKDTGALTMIPHILALVLSEDDNTREIAAQDGIVTVAIGILTDFNLKSESETEILAPKCISALLLVLSMMLQAQTKLSSEYVEGNQGGSLVPSDSPQDSTAALKDALSSDVAKGESNQALELIFGKSTGYLTMEEGHKALLIACGLIKQHVPAMIMQAVLQLCARLTKSHALAIQFLENGGLSSLFNLPKKCCFPGYDTVASVIVRHLVEDPQTLQIAMETEIRQTLSGKRHIGRVLPRTFLTTMAPVISRDPVVFMKAVASTCQLESSGGRDFVILSKEKEKPKVSGSEHGFSLNEPLGISENKLHDVSGKCSKSHRRVPANFIQVIDQLIDLVLSFPRVKRQEDGETNLISMEVDEPTTKVKGKSKVGEPEKASSSRVGEPEKAEIPEKSEELARVTFILKLLSDIVLMYSHGTSVILRRDTEISQLRGSNLPDDSPGNGGLIYHVIHRLLPISLEKFVGPEEWKEKLSEKASWFLVVLCSRSNEGRKRIINELSRVLSVFASLGRSSSKSVLLPDKRVLAFANLVYSILTKNSSSSSSNFPGCGCSPDVAKSMMDGGTIQCLTSILHVIDLDHPDAPKLVTLILKSLETLTRAANAAEQLKSEVPNEKKNRDSDERHDSHGNSTETEADELNQNNSSLQQVTDAAGNGQEQAQVSSQSAGERGSSQTQAMPQDMRIEGDETILPEPIQMDFMREEIEGDQIEMSFHVENRADDDVDDDMGDEGEDDEGDDEDADLVEDGAGVMSLAGTDVEDPEDTGLGDEYNDDMVDEDDDDFHENRVIEVRWREALDGLDHFQILGRSGGGNGFIDDITAEPFEGVNVDDLFALRRPLGFERRRQTGRSSLDRSGSEVHGFQHPLFSRPSQTGNTASVSASAGSISRHSEAGSYDVAQFYMFDTPVLPFDQVPVDPFSARLAGGGAPPPLTDYSVVGMDSSRRGVGDSRWTDIGHPQPSSLSASIAQLIEEHFISNLRASAPVNTVVERETNTTEIQEQLHPDVPPSVGSETVLGDGNEGGQQSEERELLNNNENVNNPPDVMAESFAQGQANLASPVSQDTGESLQQLEVMQPLPLNSTPNEIDRMEVGEGDGAPIDQVDHEAVHLISTAQGQPDTSSIQNVSVTAIAPPVDDPDSNFQPSVDVDMSSDGAEGNQSVQPSPLDGDNNELSSMEATENVRNDEQVEEGSLDGRAPEVNAIDPTFLEALPEDLRAEVLASQQAQSVQPPTYEPPPVDDIDPEFLAALPPDIQTEVLAQQRAQRMVQQSQGQAVDMDNASIIATLPADLREEVLLTSSEAVLAALPSPLLAEAQMLRDRAMSHYQARSSVFGSSHRLNNRRNGLGYNRLTGMDRGVGVTIGQRAVSSSADGLKVKEIEGDPLVNADALKSLIRLLRLAQPLGKGLLQRLLLNLCAHSFTRANLVQLLLDMIRPEMETSPSELAITNPQRLYGCQSNVVYGRSQLLNGLPPLVFRRVLEVLTYLATNHSAVADMLFYFDSSLLSQLSSRKGKEKVTHVTDSRDLEIPLVVFLKLLNRPQLLQSTSHLGLVMGLLQVVVYTAASRIEGWSPSSGVPEKLENKPVGEEASSETRKDAESELVGEADLSVARRKNCAEIYNIFLQLPQSDLCNLCILLGYEGLSDKIYSLAGEVLKKLAAVDVAHRKFFTKELSELASSLSSSTVRELATLSSKQKMSRSTGSMAGASILRVLQVLSSLTSPIDESNVGTERETEQEEQNIMQRLNVALEPLWHELSQCISMTELQLDHTAAASNINPGDHVLGISPTSSLSPGTQRLLPLIEAFFVLCEKIQTPSMLQQDTNVTAGEVKESSAHGSSSKTSVDSQKKTDGSVTFSKFAEKHRRLLNSFIRQNPSLLEKSLSMMLKAPRLIDFDNKKAYFRSRIRHQHDQHISGPLRISVRRAYVLEDSYNQLRMRSPQDLKGRLNVQFQGEEGIDAGGLTREWYQLLSRVIFDKGALLFTTVGNDATFQPNPNSVYQTEHLSYFKFVGRMVAKALFDGQLLDVYFTRSFYKHILGVKVTYHDIEAVDPDYYKNLKWLLENDVSDILDLTFSMDADEEKHILYEKTEVTDYELKPGGRNIRVTEETKHEYVDLVAGHILTNAIRPQINAFLEGFNELIPRELVSIFNDKELELLISGLPEIDFDDLKANTEYTSYTAGSPVIHWFWEVVKAFSKEDMARFLQFVTGTSKVPLEGFKALQGISGPQRLQIHKAYGAPERLPSAHTCFNQLDLPEYQSKEQLQERLLLAIHEASEGFGFA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
844PhosphorylationSNFLLKGSASVISEL
HHHHHHCCHHHHHHH		18.7819880383
846PhosphorylationFLLKGSASVISELSA
HHHHCCHHHHHHHHH		22.9819880383
865PhosphorylationVLKELGITYKQTIWQ
HHHHHCCCHHHHHHH		23.9119880383
866PhosphorylationLKELGITYKQTIWQM
HHHHCCCHHHHHHHH		10.1219880383
886PhosphorylationTKEDEKKSVDRGSDN
CCCHHHHHCCCCCCC		40.0830407730
891PhosphorylationKKSVDRGSDNSVSAS
HHHCCCCCCCCCCCC		34.2223776212
894PhosphorylationVDRGSDNSVSASSST
CCCCCCCCCCCCCCC		23.5723776212
896PhosphorylationRGSDNSVSASSSTAE
CCCCCCCCCCCCCCC		23.4323776212
898PhosphorylationSDNSVSASSSTAERE
CCCCCCCCCCCCCCC		19.8123776212
899PhosphorylationDNSVSASSSTAERES
CCCCCCCCCCCCCCC		31.2723776212
900PhosphorylationNSVSASSSTAERESD
CCCCCCCCCCCCCCC		29.1923776212
901PhosphorylationSVSASSSTAERESDE
CCCCCCCCCCCCCCC		34.1923776212
906PhosphorylationSSTAERESDEDSSNA
CCCCCCCCCCCCCCC		53.1523776212
910PhosphorylationERESDEDSSNALAVR
CCCCCCCCCCCEEEE		24.3623776212
911PhosphorylationRESDEDSSNALAVRY
CCCCCCCCCCEEEEE		38.1423776212
926PhosphorylationTNPVSIRSSSSQSIW
CCCCEEECCCCCCCC		32.6625561503
927PhosphorylationNPVSIRSSSSQSIWG
CCCEEECCCCCCCCC		24.9425561503
928PhosphorylationPVSIRSSSSQSIWGG
CCEEECCCCCCCCCC		33.3725561503
929PhosphorylationVSIRSSSSQSIWGGD
CEEECCCCCCCCCCC		29.8725561503
931PhosphorylationIRSSSSQSIWGGDRE
EECCCCCCCCCCCHH		23.4327288362
941PhosphorylationGGDREFLSIVRSGEG
CCCHHHHHHHHCCCC		25.1029654922
985PhosphorylationIPADLPVTSSSHELK
CCCCCCCCCCCHHHH		22.4323776212
986PhosphorylationPADLPVTSSSHELKK
CCCCCCCCCCHHHHH		30.0323776212
987PhosphorylationADLPVTSSSHELKKK
CCCCCCCCCHHHHHC		26.7523776212
988PhosphorylationDLPVTSSSHELKKKS
CCCCCCCCHHHHHCC		22.2823776212
1509PhosphorylationGSLVPSDSPQDSTAA
CCCCCCCCCCCCHHH		28.8830291188
1514PhosphorylationSDSPQDSTAALKDAL
CCCCCCCHHHHHHHH		25.0023660473
1522PhosphorylationAALKDALSSDVAKGE
HHHHHHHCCCHHCCC		26.6425561503
1523PhosphorylationALKDALSSDVAKGES
HHHHHHCCCHHCCCC		36.6325561503
1701PhosphorylationEKEKPKVSGSEHGFS
CCCCCCCCCCCCCCC		42.6023776212
1703PhosphorylationEKPKVSGSEHGFSLN
CCCCCCCCCCCCCCC		20.9324601666
1708PhosphorylationSGSEHGFSLNEPLGI
CCCCCCCCCCCCCCC		34.5723776212
2081PhosphorylationQSAGERGSSQTQAMP
CCCCCCCCCCCCCCC		26.0325561503
2082PhosphorylationSAGERGSSQTQAMPQ
CCCCCCCCCCCCCCC		39.8225561503
2263PhosphorylationGRSSLDRSGSEVHGF
CCCCCCCCCCCCCCC		46.4625561503
2265PhosphorylationSSLDRSGSEVHGFQH
CCCCCCCCCCCCCCC		37.3829654922
2288PhosphorylationTGNTASVSASAGSIS
CCCCCEEEECCCCCC		17.6325561503
2290PhosphorylationNTASVSASAGSISRH
CCCEEEECCCCCCCC		26.1729654922
2293PhosphorylationSVSASAGSISRHSEA
EEEECCCCCCCCCCC		19.6725561503
2295PhosphorylationSASAGSISRHSEAGS
EECCCCCCCCCCCCC		26.1525561503
2298PhosphorylationAGSISRHSEAGSYDV
CCCCCCCCCCCCCCC		28.2129654922
2340PhosphorylationGGAPPPLTDYSVVGM
CCCCCCCCCCEEECC		38.3723776212
2342PhosphorylationAPPPLTDYSVVGMDS
CCCCCCCCEEECCCC		9.7223776212
2343PhosphorylationPPPLTDYSVVGMDSS
CCCCCCCEEECCCCC		17.0923776212
2349PhosphorylationYSVVGMDSSRRGVGD
CEEECCCCCCCCCCC		19.4923776212
2350PhosphorylationSVVGMDSSRRGVGDS
EEECCCCCCCCCCCC		23.0223776212
2598PhosphorylationDEQVEEGSLDGRAPE
HHHHHCCCCCCCCCC		26.9419880383
2740PhosphorylationARSSVFGSSHRLNNR
HHHHHHCCHHHCCCC		16.1125561503
2741PhosphorylationRSSVFGSSHRLNNRR
HHHHHCCHHHCCCCC		17.0125561503
2773PhosphorylationTIGQRAVSSSADGLK
EECHHHHCCCCCCCC		20.0025561503
3003PhosphorylationETRKDAESELVGEAD
HHHHHHHHHHHCHHH		37.6430291188
3340PhosphorylationYNQLRMRSPQDLKGR
CHHHHCCCCCHHCCC		19.9825561503
3625PhosphorylationFKALQGISGPQRLQI
HHHHCCCCCCCHHHH		51.7729654922
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UPL1_ARATH !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UPL1_ARATH !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UPL1_ARATH !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of UPL1_ARATH !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UPL1_ARATH

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2598, AND MASSSPECTROMETRY.
"Site-specific phosphorylation profiling of Arabidopsis proteins bymass spectrometry and peptide chip analysis.";
de la Fuente van Bentem S., Anrather D., Dohnal I., Roitinger E.,Csaszar E., Joore J., Buijnink J., Carreri A., Forzani C.,Lorkovic Z.J., Barta A., Lecourieux D., Verhounig A., Jonak C.,Hirt H.;
J. Proteome Res. 7:2458-2470(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2598, AND MASSSPECTROMETRY.

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