| UniProt ID | UPK3A_HUMAN | |
|---|---|---|
| UniProt AC | O75631 | |
| Protein Name | Uroplakin-3a | |
| Gene Name | UPK3A | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 287 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass type I membrane protein. Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).. |
|
| Protein Description | Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence (By similarity).. | |
| Protein Sequence | MPPLWALLALGCLRFGSAVNLQPQLASVTFATNNPTLTTVALEKPLCMFDSKEALTGTHEVYLYVLVDSAISRNASVQDSTNTPLGSTFLQTEGGRTGPYKAVAFDLIPCSDLPSLDAIGDVSKASQILNAYLVRVGANGTCLWDPNFQGLCNAPLSAATEYRFKYVLVNMSTGLVEDQTLWSDPIRTNQLTPYSTIDTWPGRRSGGMIVITSILGSLPFFLLVGFAGAIALSLVDMGSSDGETTHDSQITQEAVPKSLGASESSYTSVNRGPPLDRAEVYSSKLQD | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 56 | Phosphorylation | FDSKEALTGTHEVYL CCCCCHHCCCCEEEE | 47.27 | - | |
| 58 | Phosphorylation | SKEALTGTHEVYLYV CCCHHCCCCEEEEEE | 15.04 | - | |
| 74 | N-linked_Glycosylation | VDSAISRNASVQDST EECHHHCCCCCCCCC | 29.76 | UniProtKB CARBOHYD | |
| 101 | Acetylation | GGRTGPYKAVAFDLI CCCCCCCEEEEEEEE | 39.25 | 19413330 | |
| 115 | Phosphorylation | IPCSDLPSLDAIGDV EECCCCCCCCCCCCH | 46.29 | 19413330 | |
| 139 | N-linked_Glycosylation | YLVRVGANGTCLWDP HEEEECCCCCCCCCC | 40.14 | UniProtKB CARBOHYD | |
| 170 | N-linked_Glycosylation | RFKYVLVNMSTGLVE HEEEEEEECCCCCCC | 17.96 | UniProtKB CARBOHYD | |
| 258 | Phosphorylation | TQEAVPKSLGASESS CHHHCCHHHCCCCCC | 26.43 | - | |
| 262 | O-linked_Glycosylation | VPKSLGASESSYTSV CCHHHCCCCCCCCCC | 35.89 | OGP | |
| 264 | O-linked_Glycosylation | KSLGASESSYTSVNR HHHCCCCCCCCCCCC | 26.58 | OGP | |
| 265 | Phosphorylation | SLGASESSYTSVNRG HHCCCCCCCCCCCCC | 28.51 | - | |
| 266 | Phosphorylation | LGASESSYTSVNRGP HCCCCCCCCCCCCCC | 16.59 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UPK3A_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UPK3A_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UPK3A_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| UPK1B_HUMAN | UPK1B | physical | 12475947 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| H00822 | Renal agenesis and Renal adysplasia | |||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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