UN45A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UN45A_RAT
• UniProt AC: Q32PZ3
• Protein Name: Protein unc-45 homolog A
• Gene Name: Unc45a
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 944
• Subcellular Localization: Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Predominant in the perinuclear region. Little protein in the nucleus (By similarity)..
• Protein Description: May act as co-chaperone for HSP90 (Potential). Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell (By similarity). May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity)..
• Protein Sequence: MTVSGPGTPEPRPSDPGASSAEELRKEGNELFKCGDYEGALTAYTQALSLGATPQDQAILHRNRAACHLKLEDYSKAESEASKAIEKDGGDVKALYRRSQALEKLGRLDQAVLDLKRCVSLEPKNKVFQESLRNIGGQIQEKVRYMSSTDAKVEQMFQILLDPKEKGTEKKQKASQNLVVLAREDAGAEKIFRSNGVQLLQRLLDTGETDLMLAALRTLVGICSEHQSRTVATLSVLGTRRVVSILGVENQAVSLAACHLLQVMFDALKEGVKKGFRGKEGAIIVDPARELKVLISNLLELLTEIGVSGQGRDNALTLLIKMVPRKSPKDPNNSLTLWVIDQGLKKILEVGGSVPEAAGELTVTANSRMSASILLSKLFDDLKCDAERENFHRLCENYIRSWFEGQGLAGKLRAIQTVSCLLQGPCDAGNRALELSGVMESVIALCASEQEEEQLVAVEALIHAAGKAKRASFITANGVALLKDLYKGSERDSIRIRALVGLCKLGSAGGTDFSMKQFAEGSTLKLAKQCRKWLCNDQIDAGTRRWAVEGLAYLTFDADVKEEFVEDEAALKALFQLSRSEERSVLFAVGSALVNCTNSYDYEEPDPKMVELAKYAKQHVPEQHPKDKPSFVRARVKKLLAAGVVSAMTCMVKTESPVLTNSCRELLSRVFLALVEEVEDRGTVVAQGGGKALLPLALEGTDVGQTKAAQALAKLTITSNPEMTFPGERIYEVVRPLVSLLHLSCSGLQNFEALMALTNLAGISERLRQKILKEKAVPMIEGYMFEEHEMIRRAATECMCNLAMSKEVQDLFEAQGNDRLKLLVLYSGEDDELLRRAAAGGLAMLTSMRPSLCSRIPQVTTHWLEILQALLLSPNPELQHRGTVVVLNMMESSKEIASTLMESEVLEILSVLAKGEESPVTRAAAACLEKAVEYRLIQPNQDGE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTVSGPGTP ------CCCCCCCCC	24.31	28432305
4	Phosphorylation	----MTVSGPGTPEP ----CCCCCCCCCCC	30.06	28432305
8	Phosphorylation	MTVSGPGTPEPRPSD CCCCCCCCCCCCCCC	27.84	28432305
14	Phosphorylation	GTPEPRPSDPGASSA CCCCCCCCCCCCCCH	58.69	25575281
20	Phosphorylation	PSDPGASSAEELRKE CCCCCCCCHHHHHHH	38.88	22673903
70	Acetylation	NRAACHLKLEDYSKA CCEEHHCCHHHHHHH	26.60	-
120	Phosphorylation	LDLKRCVSLEPKNKV HHHHHHHCCCCCCHH	30.55	30181290
472	Phosphorylation	AGKAKRASFITANGV HHHHHHHHEEEEHHH	22.63	23984901
475	Phosphorylation	AKRASFITANGVALL HHHHHEEEEHHHHHH	16.44	23984901
483	Acetylation	ANGVALLKDLYKGSE EHHHHHHHHHHCCCC	46.68	-
493	Phosphorylation	YKGSERDSIRIRALV HCCCCCHHHHHHHHH	21.71	26022182
580	Phosphorylation	ALFQLSRSEERSVLF HHHHHCCCCCHHHHH	40.20	25403869
668	Phosphorylation	NSCRELLSRVFLALV HHHHHHHHHHHHHHH	38.74	30181290

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UN45A_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UN45A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UN45A_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of UN45A_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.