UN13A_MOUSE - dbPTM
UN13A_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UN13A_MOUSE
UniProt AC Q4KUS2
Protein Name Protein unc-13 homolog A
Gene Name Unc13a {ECO:0000312|MGI:MGI:3051532}
Organism Mus musculus (Mouse).
Sequence Length 1712
Subcellular Localization Cytoplasm . Cell membrane
Peripheral membrane protein . Cell junction, synapse, presynaptic cell membrane
Peripheral membrane protein . Localized to the active zone of presynaptic density. Translocated to the plasma membrane in response to phorbo
Protein Description Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes (By similarity)..
Protein Sequence MSLLCVGVKKAKFDGAQEKFNTYVTLKVQNVKSTTIAVRGSQPSWEQDFMFEINRLDLGLTVEVWNKGLIWDTMVGTVWIPLRTIRQSNEEGPGEWLTLDSQAIMADSEICGTKDPTFHRILLDAHFELPLDIPEEEARYWAKKLEQLNAMRDQDEYSFQDQQDKPLPVPSSQCCNWNYFGWGEQNDDPDSAVDDRDSDYRSETSNSIPPPYYTTSQPNASVHQYSVRPPPLGSRESYSDSMHSYEEFSEPRALSPTGSSRYASSGELSQGSSQLSEDFDPDEHSLQGSELDDERDRDSYHSCHSSVSYHKDSPRWDQDDEDLEDLEDLEDEELPEEEEELEEEGEEELEEEDLEEEEEVPDDLASYTQQEDTTVAEPKEFKRISFPTAAPQKDDKVSAVPTEAPEVAKGIPKAATPEEKAAAERAQEAEPPKSEESFRSREEEEGQEGQDAMSRAKANWLRAFNKVRMQLQEARGEGDMSKSLWFKGGPGGGLIIIDSMPDIRKRKPIPLVSDLAMSLVQSRKAGITSALASSTLNNEELKNHVYKKTLQALIYPISCTTPHNFEVWTATTPTYCYECEGLLWGIARQGMRCTECGVKCHEKCQDLLNADCLQRAAEKSSKHGAEDRTQNIIMVLKDRMKIRERNKPEIFELIQEIFAVTKSAHTQQMKAVKQSVLDGTSKWSAKISITVVCAQGLQAKDKTGSSDPYVTVQVGKTKKRTKTIYGNLNPVWEENFHFECHNSSDRIKVRVWDEDDDIKSRVKQRFKRESDDFLGQTIIEVRTLSGEMDVWYNLDKRTDKSAVSGAIRLHISVEIKGEEKVAPYHVQYTCLHENLFHFVTDVQNNGVVKIPDAKGDDAWKVYYDETAQEIVDEFAMRYGVESIYQAMTHFACLSSKYMCPGVPAVMSTLLANINAYYAHTTASTNVSASDRFAASNFGKERFVKLLDQLHNSLRIDLSMYRNNFPASSPERLQDLKSTVDLLTSITFFRMKVQELQSPPRASQVVKDCVKACLNSTYEYIFNNCHELYGREYQTDPAKKGEVPPEEQGPSIKNLDFWSKLITLIVSIIEEDKNSYTPCLNQFPQELNVGKISAEVMWSLFAQDMKYAMEEHDKHRLCKSADYMNLHFKVKWLYNEYVAELPTFKDRVPEYPAWFEPFVIQWLDENEEVSRDFLHGALERDKKDGFQQTSEHALFSCSVVDVFSQLNQSFEIIKKLECPDPQIVGHYMRRFAKTISNVLLQYADIVSKDFASYCSKEKEKVPCILMNNTQQLRVQLEKMFEAMGGKELDAEASGTLKELQVKLNNVLDELSHVFATSFQPHIEECVRQMGDILSQVKGTGNVPASACSSVAQDADNVLQPIMDLLDSNLTLFAKICEKTVLKRVLKELWKLVMNTMEKTIVLPPLTDQTMIGTLLRKHGKGLEKGRVKLPSHSDGTQMIFNAAKELGQLSKLKDHMVREEAKSLTPKQCAVVELALDTIKQYFHAGGVGLKKTFLEKSPDLQSLRYALSLYTQATDLLIKTFVQTQSAQGSGVEDPVGEVSVHVELFTHPGTGEQKVTVKVVAANDLKWQTSGIFRPFIEVNIVGPQLSDKKRKFATKSKNNSWAPKYNESFQFSLSADAGPECYELQVCVKDYCFAREDRTVGLAVLQLRELAQRGSAACWLPLGRRIHMDDTGLTVLRILSQRSNDEVAKEFVKLKSDTRSAEEGGAAPAP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
98PhosphorylationEGPGEWLTLDSQAIM
CCCCCEEEECHHHHH		29.5928059163
237PhosphorylationPPLGSRESYSDSMHS
CCCCCCCCCCCCCCC		28.9129899451
238PhosphorylationPLGSRESYSDSMHSY
CCCCCCCCCCCCCCC		16.2529899451
239PhosphorylationLGSRESYSDSMHSYE
CCCCCCCCCCCCCCH		32.2722324799
241PhosphorylationSRESYSDSMHSYEEF
CCCCCCCCCCCCHHC		16.6822324799
244PhosphorylationSYSDSMHSYEEFSEP
CCCCCCCCCHHCCCC		26.1222324799
245PhosphorylationYSDSMHSYEEFSEPR
CCCCCCCCHHCCCCC		12.5624925903
249PhosphorylationMHSYEEFSEPRALSP
CCCCHHCCCCCCCCC		50.3924925903
255PhosphorylationFSEPRALSPTGSSRY
CCCCCCCCCCCCCCC		21.3025521595
257PhosphorylationEPRALSPTGSSRYAS
CCCCCCCCCCCCCCC		46.4428066266
259PhosphorylationRALSPTGSSRYASSG
CCCCCCCCCCCCCCC		17.7025521595
260PhosphorylationALSPTGSSRYASSGE
CCCCCCCCCCCCCCC		30.5619060867
299PhosphorylationDDERDRDSYHSCHSS
CCCCCHHCCCCCHHC		26.1620415495
300PhosphorylationDERDRDSYHSCHSSV
CCCCHHCCCCCHHCC		11.3120415495
302PhosphorylationRDRDSYHSCHSSVSY
CCHHCCCCCHHCCCC		12.8020415495
305PhosphorylationDSYHSCHSSVSYHKD
HCCCCCHHCCCCCCC		36.4420415495
306PhosphorylationSYHSCHSSVSYHKDS
CCCCCHHCCCCCCCC		7.4520415495
308PhosphorylationHSCHSSVSYHKDSPR
CCCHHCCCCCCCCCC		24.3820415495
309PhosphorylationSCHSSVSYHKDSPRW
CCHHCCCCCCCCCCC		15.6720415495
313PhosphorylationSVSYHKDSPRWDQDD
CCCCCCCCCCCCCCC		22.5920415495
385PhosphorylationPKEFKRISFPTAAPQ
CCHHCCCCCCCCCCC		29.2525521595
388PhosphorylationFKRISFPTAAPQKDD
HCCCCCCCCCCCCCC		33.1829899451
416PhosphorylationKGIPKAATPEEKAAA
CCCCCCCCHHHHHHH		35.7729899451
434PhosphorylationQEAEPPKSEESFRSR
HHCCCCCCHHHHHHH		52.9829899451
437PhosphorylationEPPKSEESFRSREEE
CCCCCHHHHHHHHHH		23.1629899451
440PhosphorylationKSEESFRSREEEEGQ
CCHHHHHHHHHHHCC		41.8725521595
454PhosphorylationQEGQDAMSRAKANWL
CCHHHHHHHHHHHHH		30.7029899451
499PhosphorylationGGLIIIDSMPDIRKR
CCEEEECCCCCHHCC		23.0822324799
518PhosphorylationLVSDLAMSLVQSRKA
HHHHHHHHHHHHHHH		21.5629899451
688PhosphorylationSKWSAKISITVVCAQ
CCCCEEEEEEEEECC		16.1129109428
690PhosphorylationWSAKISITVVCAQGL
CCEEEEEEEEECCCC		10.4929109428
1012S-palmitoylationVKDCVKACLNSTYEY
HHHHHHHHHHCHHHH		2.8328680068
1019PhosphorylationCLNSTYEYIFNNCHE
HHHCHHHHHHCCHHH		10.6126160508
1130UbiquitinationMNLHFKVKWLYNEYV
CCHHEEEHHHHHHHH		31.8822790023
1430PhosphorylationKGRVKLPSHSDGTQM
CCCEECCCCCHHHHH		46.1629899451
1432PhosphorylationRVKLPSHSDGTQMIF
CEECCCCCHHHHHHH		41.9129899451
1435PhosphorylationLPSHSDGTQMIFNAA
CCCCCHHHHHHHHHH		21.6929899451
1682PhosphorylationLTVLRILSQRSNDEV
HHHHHHHHHCCCHHH		22.6029899451
1685PhosphorylationLRILSQRSNDEVAKE
HHHHHHCCCHHHHHH		40.7829899451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UN13A_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UN13A_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UN13A_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of UN13A_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UN13A_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Comprehensive identification of phosphorylation sites in postsynapticdensity preparations.";
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R.,Burlingame A.L.;
Mol. Cell. Proteomics 5:914-922(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-244, AND MASSSPECTROMETRY.

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