UKL1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UKL1_ARATH
• UniProt AC: Q9FKS0
• Protein Name: Uridine kinase-like protein 1, chloroplastic
• Gene Name: UKL1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 486
• Subcellular Localization: Plastid, chloroplast . Cytoplasm . Aggregates in granular precipitates restricted to the cytoplasm, when expressed in transfected cells.
• Protein Description: Involved in the pyrimidine salvage pathway. The uracil phosphoribosyltransferase (UPRT) activity, that catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate, is unsure..
• Protein Sequence: MPEDSSSLDYAMEKASGPHFSGLRFDGLLSSSPPNSSVVSSLRSAVSSSSPSSSDPEAPKQPFIIGVSGGTASGKTTVCDMIIQQLHDHRVVLVNQDSFYRGLTSEELQRVQEYNFDHPDAFDTEQLLHCAETLKSGQPYQVPIYDFKTHQRRSDTFRQVNASDVIILEGILVFHDSRVRNLMNMKIFVDTDADVRLARRIRRDTVERGRDVNSVLEQYAKFVKPAFDDFVLPSKKYADVIIPRGGDNHVAVDLITQHIHTKLGQHDLCKIYPNVYVIQSTFQIRGMHTLIREKDISKHDFVFYSDRLIRLVVEHGLGHLPFTEKQVVTPTGAVYTGVDFCKKLCGVSIIRSGESMENALRACCKGIKIGKILIHRDGDNGKQLIYEKLPHDISERHVLLLDPVLATGNSANQAIELLIQKGVPEAHIIFLNLISAPEGIHCVCKRFPALKIVTSEIDQCLNQEFRVIPGLGEFGDRYFGTDEEDQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	LRFDGLLSSSPPNSS CCCCCCCCCCCCCCH	33.54	23776212
31	Phosphorylation	RFDGLLSSSPPNSSV CCCCCCCCCCCCCHH	47.00	23776212
32	Phosphorylation	FDGLLSSSPPNSSVV CCCCCCCCCCCCHHH	40.79	23776212
36	Phosphorylation	LSSSPPNSSVVSSLR CCCCCCCCHHHHHHH	30.22	23776212
37	Phosphorylation	SSSPPNSSVVSSLRS CCCCCCCHHHHHHHH	32.93	23776212
40	Phosphorylation	PPNSSVVSSLRSAVS CCCCHHHHHHHHHHH	22.84	23776212
41	Phosphorylation	PNSSVVSSLRSAVSS CCCHHHHHHHHHHHC	19.05	23776212
44	Phosphorylation	SVVSSLRSAVSSSSP HHHHHHHHHHHCCCC	38.01	23776212
47	Phosphorylation	SSLRSAVSSSSPSSS HHHHHHHHCCCCCCC	24.99	23776212
48	Phosphorylation	SLRSAVSSSSPSSSD HHHHHHHCCCCCCCC	28.39	23776212
49	Phosphorylation	LRSAVSSSSPSSSDP HHHHHHCCCCCCCCC	38.47	23776212
50	Phosphorylation	RSAVSSSSPSSSDPE HHHHHCCCCCCCCCC	30.65	30291188
52	Phosphorylation	AVSSSSPSSSDPEAP HHHCCCCCCCCCCCC	44.41	23776212
53	Phosphorylation	VSSSSPSSSDPEAPK HHCCCCCCCCCCCCC	41.99	23776212
54	Phosphorylation	SSSSPSSSDPEAPKQ HCCCCCCCCCCCCCC	62.62	23776212
481	Phosphorylation	FGDRYFGTDEEDQ-- CCCCCCCCCCCCC--	30.27	29654922

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UKL1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UKL1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UKL1_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of UKL1_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, AND MASSSPECTROMETRY.
PubMed: 19376835