UGGG_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UGGG_ARATH
• UniProt AC: Q0WL80
• Protein Name: UDP-glucose:glycoprotein glucosyltransferase
• Gene Name: UGGT
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1613
• Subcellular Localization: Endoplasmic reticulum lumen .
• Protein Description: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. Required for elongation factor Tu receptor (EFR), but not flagellin-sensing 2 (FLS2) signaling..
• Protein Sequence: MGTTTNLRSWLYLILLFIVVVGVNAQNRRPKNVQVAVKAKWQGTPLLLEAGELISKESKQLFWEFTDAWLGSDGDDSDCKSARDCLLKISKQASTLLAQPVASLFHFSLTLRSASPRLVLYRQLADESLSSFPHGDDPSATGCCWVDTGSSLFYDVADLQSWLASAPAVGDAVQGPELFDFDHVHFDSRAGSPVAVLYGAVGTDCFRKFHLSLAKAAKEGKVTYVVRPVLPLGCEGKTRPCGAIGARDNVSLAGYGVELALKNMEYKAMDDSAIKKGITLEDPRTEDLSQDVRGFIFSKILDRKPELRSEVMAFRDYLLSSTVSDTLDVWELKDLGHQTAQRIVHASDPLQSMQEINQNFPSVVSSLSRMKLNESIKDEILSNQRMVPPGKALLALNGALLNIEDIDLYMLMDLAHQELSLANHFSKLKIPDGAIRKLLLTTPLPEPDSYRVDFRSVHVTYLNNLEEDDMYKRWRSNINEILMPAFPGQLRYIRKNLFHAVYVIDPATACGLESIETLRSLYENQLPVRFGVILYSTQLIKTIENNGGQIPSSDAVTNAQVKEDLSTMVIRLFLYIKEHHGIQTAFQFLGNLNTLRTESADSSEADIEQEHVDGAFVETILPKVKTLPQDILLKLRQEHTLKEASEASSMFVFKLGLAKLKCSFLMNGLVFDSVEEETLLNAMNEELPKIQEQVYYGQIESHTKVLDKLLSESGLSRYNPQIISGGKNKPRFVSLASSTRKGESMLNDVNYLHSPETSEDVKYVTHLLAADVATKKGMKLLHEGVRYLIGGSKSARLGVLFSSSQNADPHSLLFIKFFEKTASSFSHKEKVLYFLDKLCLFYEREYLLKTSVESASSQMFIDKVLELADEYGLSSKAYRSCLVESVDEELLKRLTKVAQFLSWELGLESDANAIISNGRVIFPVDERTFLGQDLHLLESMEFNQRVKPVQEIIEGIEWQDVDPDLLTSKYFSDVFMFVSSAMATRDRSSESARFEVLNSEYSAVLLGNENATIHIDAVIDPLSPTGQKLASLLQVLQKHVQTSMRIVLNPMSSLVDIPLKNYYRYVLPNTDDYSSTGFDVDGPKAFFANMPLSKTLTMNLDVPEPWLVEPVIAIHDLDNILLENLGDTTTLQAVFEVESLVLTGHCAEKDHEAPRGLQLILGTKNRPHLVDTLVMANLGYWQMKVSPGVWYLQLAPGRSSELYALKGGNDGSQDQSSLKRITIDDLRGKVVHLEVVKRKGKEHEKLLVPSDGDDAVQQNKEGSWNSNFLKWASGFVGGRQQSMKGGPDKEHEKGGRQGKTINIFSIASGHLYERFLKIMILSVLKNTNRPVKFWFIKNYLSPQFKDVIPHMAQEYNFEYELITYKWPSWLHKQKEKQRIIWAYKILFLDVIFPLSLEKVIFVDADQIIRTDMGELYDMDIKGRPLAYTPFCDNNREMDGYKFWKQGFWKEHLRGRPYHISALYVVDLVKFRETAAGDNLRVFYETLSKDPNSLSNLDQDLPNYAQHTVPIFSLPQEWLWCESWCGNATKAKARTIDLCNNPMTKEPKLQGARRIVTEWPDLDLEARKFTAKILGEDVELNEPVAAPATDKPNPLPSNDISEDTEQDLESKAEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
249	N-linked_Glycosylation	GAIGARDNVSLAGYG CCCCCCCCEEECCHH	21.52	-
373	N-linked_Glycosylation	SLSRMKLNESIKDEI HHHHHCCCHHHHHHH	35.14	-
502	Phosphorylation	KNLFHAVYVIDPATA HHCCCEEEEECHHHH	7.77	23172892
508	Phosphorylation	VYVIDPATACGLESI EEEECHHHHCCHHHH	28.06	23172892
514	Phosphorylation	ATACGLESIETLRSL HHHCCHHHHHHHHHH	30.66	23172892
517	Phosphorylation	CGLESIETLRSLYEN CCHHHHHHHHHHHHC	26.29	23172892
1010	N-linked_Glycosylation	AVLLGNENATIHIDA EEEECCCCCEEEEEE	46.51	-
1186	Phosphorylation	GYWQMKVSPGVWYLQ CCEEEEECCCEEEEE	15.49	25368622
1191	Phosphorylation	KVSPGVWYLQLAPGR EECCCEEEEEECCCC	5.12	25368622
1526	N-linked_Glycosylation	WCESWCGNATKAKAR ECCHHCCCCHHHHHH	41.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UGGG_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UGGG_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UGGG_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of UGGG_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.