UD17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UD17_HUMAN
• UniProt AC: Q9HAW7
• Protein Name: UDP-glucuronosyltransferase 1-7
• Gene Name: UGT1A7
• Organism: Homo sapiens (Human).
• Sequence Length: 530
• Subcellular Localization: Microsome. Endoplasmic reticulum membrane ; Single-pass membrane protein .
• Protein Description: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1..
• Protein Sequence: MARAGWTGLLPLYVCLLLTCGFAKAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLFFSNCRSLFNDRKLVEYLKESCFDAVFLDPFDACGLIVAKYFSLPSVVFARGIFCHYLEEGAQCPAPLSYVPRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPVTAYDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
71	N-linked_Glycosylation	WQLGRSLNCTVKTYS HHHCCCCCCEEEEEE	22.21	UniProtKB CARBOHYD
76	Phosphorylation	SLNCTVKTYSTSYTL CCCCEEEEEEEEEEC	20.54	25072903
77	Phosphorylation	LNCTVKTYSTSYTLE CCCEEEEEEEEEECC	12.30	25072903
78	Phosphorylation	NCTVKTYSTSYTLED CCEEEEEEEEEECCC	18.99	25072903
79	Phosphorylation	CTVKTYSTSYTLEDQ CEEEEEEEEEECCCC	18.48	25072903
80	Phosphorylation	TVKTYSTSYTLEDQD EEEEEEEEEECCCCC	15.35	25072903
81	Phosphorylation	VKTYSTSYTLEDQDR EEEEEEEEECCCCCC	18.55	25072903
82	Phosphorylation	KTYSTSYTLEDQDRE EEEEEEEECCCCCCE	24.36	25072903
292	N-linked_Glycosylation	MEFEAYINASGEHGI CEEEEEEECCCCCEE	18.51	UniProtKB CARBOHYD
329	Phosphorylation	ALGKIPQTVLWRYTG HHCCCCHHHHHHCCC	16.53	23403867
334	Phosphorylation	PQTVLWRYTGTRPSN CHHHHHHCCCCCCCH	9.65	-
337	Phosphorylation	VLWRYTGTRPSNLAN HHHHCCCCCCCHHCC	31.44	23403867
340	Phosphorylation	RYTGTRPSNLANNTI HCCCCCCCHHCCCEE	40.98	23403867
344	N-linked_Glycosylation	TRPSNLANNTILVKW CCCCHHCCCEEEEEE	49.71	UniProtKB CARBOHYD
346	Phosphorylation	PSNLANNTILVKWLP CCHHCCCEEEEEECC	18.59	23403867
363	Phosphorylation	DLLGHPMTRAFITHA CCCCCCCHHHHHHCC	24.24	23403867
432	Phosphorylation	KAVINDKSYKENIMR HHHHCCHHHHHHHHH	44.28	15845768
434	Acetylation	VINDKSYKENIMRLS HHCCHHHHHHHHHHH	51.91	18530747

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
432	S	Phosphorylation	Kinase	PRKCE	Q02156	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UD17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UD17_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of UD17_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00688: Mycophenolate mofetil
• DB01024: Mycophenolic acid