| UniProt ID | UD16_HUMAN | |
|---|---|---|
| UniProt AC | P19224 | |
| Protein Name | UDP-glucuronosyltransferase 1-6 | |
| Gene Name | UGT1A6 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 532 | |
| Subcellular Localization |
Microsome. Endoplasmic reticulum membrane Single-pass membrane protein . |
|
| Protein Description | UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform has specificity for phenols. Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1 (By similarity).. | |
| Protein Sequence | MACLLRSFQRISAGVFFLALWGMVVGDKLLVVPQDGSHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRKIYPVPYDQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGLYFINCQSLLQDRDTLNFFKESKFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEHTFSRSPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEELASAVLKRDVDIITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 50 | Phosphorylation | KDIVEVLSDRGHEIV HHHHHHHHHCCCEEE | 30.36 | - | |
| 91 | Phosphorylation | QEELKNRYQSFGNNH HHHHHHHHHHHCCCC | 20.22 | - | |
| 93 | Phosphorylation | ELKNRYQSFGNNHFA HHHHHHHHHCCCCHH | 26.62 | - | |
| 220 | Phosphorylation | LVNLLEPYLFYCLFS HHHHHHHHHHHHHHH | 10.48 | - | |
| 223 | Phosphorylation | LLEPYLFYCLFSKYE HHHHHHHHHHHHCHH | 5.90 | - | |
| 227 | Phosphorylation | YLFYCLFSKYEELAS HHHHHHHHCHHHHHH | 22.75 | 24719451 | |
| 229 | Phosphorylation | FYCLFSKYEELASAV HHHHHHCHHHHHHHH | 17.28 | - | |
| 294 | N-linked_Glycosylation | QEFEAYINASGEHGI HHHHHHHHCCCCCEE | 18.51 | UniProtKB CARBOHYD | |
| 331 | Phosphorylation | ALGKIPQTVLWRYTG HHCCCCHHHHHHCCC | 16.53 | 23403867 | |
| 336 | Phosphorylation | PQTVLWRYTGTRPSN CHHHHHHCCCCCCCH | 9.65 | - | |
| 339 | Phosphorylation | VLWRYTGTRPSNLAN HHHHCCCCCCCHHCC | 31.44 | 23403867 | |
| 342 | Phosphorylation | RYTGTRPSNLANNTI HCCCCCCCHHCCCEE | 40.98 | 23403867 | |
| 346 | N-linked_Glycosylation | TRPSNLANNTILVKW CCCCHHCCCEEEEEE | 49.71 | UniProtKB CARBOHYD | |
| 348 | Phosphorylation | PSNLANNTILVKWLP CCHHCCCEEEEEECC | 18.59 | 23403867 | |
| 365 | Phosphorylation | DLLGHPMTRAFITHA CCCCCCCHHHHHHCC | 24.24 | 23403867 | |
| 434 | Phosphorylation | KAVINDKSYKENIMR HHHHCCHHHHHHHHH | 44.28 | 15845768 | |
| 436 | Acetylation | VINDKSYKENIMRLS HHCCHHHHHHHHHHH | 51.91 | 18530369 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UD16_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UD16_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UD16_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CP3A4_HUMAN | CYP3A4 | physical | 15486048 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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