UCP1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UCP1_RAT
• UniProt AC: P04633
• Protein Name: Mitochondrial brown fat uncoupling protein 1 {ECO:0000305}
• Gene Name: Ucp1 {ECO:0000312|RGD:3931}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 307
• Subcellular Localization: Mitochondrion inner membrane ; Multi-pass membrane protein .
• Protein Description: Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance (By similarity). Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. [PubMed: 12479871]
• Protein Sequence: MVSSTTSEVQPTMGVKIFSAGVSACLADIITFPLDTAKVRLQIQGEGQASSTIRYKGVLGTITTLAKTEGLPKLYSGLPAGIQRQISFASLRIGLYDTVQEYFSSGRETPASLGSKISAGLMTGGVAVFIGQPTEVVKVRMQAQSHLHGIKPRYTGTYNAYRVIATTESLSTLWKGTTPNLMRNVIINCTELVTYDLMKGALVNHHILADDVPCHLLSALVAGFCTTLLASPVDVVKTRFINSLPGQYPSVPSCAMTMYTKEGPAAFFKGFAPSFLRLGSWNVIMFVCFEQLKKELMKSRQTVDCTT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MVSSTTSEVQ -----CCCCCCCCCC	22.22	18486593
4	Phosphorylation	----MVSSTTSEVQP ----CCCCCCCCCCC	25.05	18486593
51	Phosphorylation	QGEGQASSTIRYKGV CCCCCCCCEEEEEEE	30.76	22817900
67	Acetylation	GTITTLAKTEGLPKL HHHHHHHHHCCCCHH	50.66	22902405
73	Acetylation	AKTEGLPKLYSGLPA HHHCCCCHHHCCCCH	66.16	22902405
151	Acetylation	QSHLHGIKPRYTGTY HHHHCCCCCCCCCCC	28.21	22902405
254	Cysteine sulfenic acid (-SOH)	QYPSVPSCAMTMYTK CCCCCCCEEEEEEEC	2.16	-
254	Oxidation	QYPSVPSCAMTMYTK CCCCCCCEEEEEEEC	2.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UCP1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UCP1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UCP1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_RAT	Ubc	physical	22531154

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.