UCHL4_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UCHL4_MOUSE
• UniProt AC: P58321
• Protein Name: Ubiquitin carboxyl-terminal hydrolase isozyme L4
• Gene Name: Uchl4
• Organism: Mus musculus (Mouse).
• Sequence Length: 233
• Subcellular Localization: Cytoplasm.
• Protein Description: Ubiquitin-protein hydrolase is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin..
• Protein Sequence: MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMESELLSIIPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGTIGLIHAIANNKDKVHFESGSTLKKFLEESVSMSPEERAKYLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGWKPFPINHGKTSDETLLEDVIKVCKKFMERDPDELRFNAIALSAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	Ubiquitination	LLFPITEKYEVFRTE HHEECCCCEEECCCH	37.75	-
74	Ubiquitination	TEEEEKIKSQGQDVT CHHHHHHHHCCCCCH	48.04	-
124	Acetylation	ESGSTLKKFLEESVS CCCHHHHHHHHHHHC	59.29	22826441
124	Ubiquitination	ESGSTLKKFLEESVS CCCHHHHHHHHHHHC	59.29	-
129	Phosphorylation	LKKFLEESVSMSPEE HHHHHHHHHCCCHHH	15.32	26239621
131	Phosphorylation	KFLEESVSMSPEERA HHHHHHHCCCHHHHH	23.87	26239621
133	Phosphorylation	LEESVSMSPEERAKY HHHHHCCCHHHHHHH	22.96	27742792
164	Phosphorylation	EGQTEAPSIDEKVDL CCCCCCCCCCCCCCE	50.12	26824392
168	Ubiquitination	EAPSIDEKVDLHFIA CCCCCCCCCCEEEEE	36.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UCHL4_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UCHL4_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UCHL4_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of UCHL4_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-133, AND MASSSPECTROMETRY.
PubMed: 17203969