UCHL1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UCHL1_RAT
• UniProt AC: Q00981
• Protein Name: Ubiquitin carboxyl-terminal hydrolase isozyme L1
• Gene Name: Uchl1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 223
• Subcellular Localization: Cytoplasm. Endoplasmic reticulum membrane; Lipid-anchor.
• Protein Description: Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity (By similarity)..
• Protein Sequence: MQLKPMEINPEMLNKVLAKLGVAGQWRFADVLGLEEETLGSVPSPACALLLLFPLTAQHENFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLEFEDGSVLKQFLSETEKLSPEDRAKCFEKNEAIQAAHDSVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMPFPVNHGASSEDSLLQDAAKVCREFTEREQGEVRFSAVALCKAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MQLKPMEINPE ----CCCCCCCCCHH	25.98	-
4	Acetylation	----MQLKPMEINPE ----CCCCCCCCCHH	25.98	22902405
15	Acetylation	INPEMLNKVLAKLGV CCHHHHHHHHHHHCC	34.36	22902405
19	Acetylation	MLNKVLAKLGVAGQW HHHHHHHHHCCCCCC	41.43	22902405
64	Ubiquitination	AQHENFRKKQIEELK HCCCCHHHHHHHHHC	44.91	-
71	Acetylation	KKQIEELKGQEVSPK HHHHHHHCCCCCCHH	62.92	22902405
71	Ubiquitination	KKQIEELKGQEVSPK HHHHHHHCCCCCCHH	62.92	-
78	Acetylation	KGQEVSPKVYFMKQT CCCCCCHHHEEEECC	41.90	22902405
123	Acetylation	QFLSETEKLSPEDRA HHHHHHHCCCHHHHH	62.78	22902405
123	Ubiquitination	QFLSETEKLSPEDRA HHHHHHHCCCHHHHH	62.78	-
125	Phosphorylation	LSETEKLSPEDRAKC HHHHHCCCHHHHHHH	36.99	30240740
135	Ubiquitination	DRAKCFEKNEAIQAA HHHHHHHHHHHHHHH	39.57	-
152	S-nitrosocysteine	SVAQEGQCRVDDKVN HHHHCCCCCCCCCEE	7.23	-
152	S-nitrosylation	SVAQEGQCRVDDKVN HHHHCCCCCCCCCEE	7.23	22178444
157	Ubiquitination	GQCRVDDKVNFHFIL CCCCCCCCEEEEEEE	34.32	-
188	Phosphorylation	FPVNHGASSEDSLLQ CCCCCCCCCHHHHHH	38.56	25403869
189	Phosphorylation	PVNHGASSEDSLLQD CCCCCCCCHHHHHHH	44.91	25403869
192	Phosphorylation	HGASSEDSLLQDAAK CCCCCHHHHHHHHHH	27.25	25403869
220	S-nitrosocysteine	RFSAVALCKAA---- EEEEEHHHHCC----	1.71	-
220	Farnesylation	RFSAVALCKAA---- EEEEEHHHHCC----	1.71	-
220	S-nitrosylation	RFSAVALCKAA---- EEEEEHHHHCC----	1.71	21278135

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UCHL1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UCHL1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UCHL1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NTRK2_RAT	Ntrk2	physical	28500221

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.