UBX2B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBX2B_MOUSE
• UniProt AC: Q0KL01
• Protein Name: UBX domain-containing protein 2B
• Gene Name: Ubxn2b
• Organism: Mus musculus (Mouse).
• Sequence Length: 331
• Subcellular Localization: Nucleus . Cytoplasm, cytosol . Endoplasmic reticulum . Golgi apparatus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes to centrosome during mitotic prophase and metaphase.
• Protein Description: Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. Together with NSFL1C/p47, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis..
• Protein Sequence: MAEGGRAEPEEQERGSSRPRPPSARDLQLALAELYEDEMKCKSSKPDRSTPATCRSPRTPPHRLYSGDHKYDGLHIVQPPTGKIVNELFKEAREHGAVPLNEATRSSREDKTKSFTGGGYRLGNSFYKRSEYIYGENQLQDVQVLLKLWRNGFSLDDGELRPYSDPTNAQFLESVKRGETPLELQRLVHGAQVNLDMEDHQDQEYIKPRLRFKAFSGEGQKLGSLTPEIVSTPSSPEEEDKSILNAAVLIDDSMPTTKIQIRLADGSRLVQRFNSTHRILDVRDFIVRSRPEFATTDFILVTSFPSKELTDETVTLQEADILNTVILQQLK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEGGRAEP ------CCCCCCCCH	24.92	-
23	Phosphorylation	SSRPRPPSARDLQLA CCCCCCCCHHHHHHH	38.32	29472430
50	Phosphorylation	SSKPDRSTPATCRSP CCCCCCCCCCCCCCC	20.17	-
53	Phosphorylation	PDRSTPATCRSPRTP CCCCCCCCCCCCCCC	15.06	29514104
56	Phosphorylation	STPATCRSPRTPPHR CCCCCCCCCCCCCCC	22.38	29472430
59	Phosphorylation	ATCRSPRTPPHRLYS CCCCCCCCCCCCCCC	44.55	22817900
66	Phosphorylation	TPPHRLYSGDHKYDG CCCCCCCCCCCCCCC	42.19	22817900
107	Phosphorylation	LNEATRSSREDKTKS CCHHHCCCCCCCCCC	36.08	29899451
154	Phosphorylation	KLWRNGFSLDDGELR HHHHCCCCCCCCCCC	32.08	29899451
216	Phosphorylation	RLRFKAFSGEGQKLG EEEEEEECCCCCCCC	40.57	25521595
224	Phosphorylation	GEGQKLGSLTPEIVS CCCCCCCCCCCCHHC	39.23	25619855
226	Phosphorylation	GQKLGSLTPEIVSTP CCCCCCCCCCHHCCC	22.14	25619855
231	Phosphorylation	SLTPEIVSTPSSPEE CCCCCHHCCCCCHHH	40.02	25619855
232	Phosphorylation	LTPEIVSTPSSPEEE CCCCHHCCCCCHHHH	19.12	25619855
234	Phosphorylation	PEIVSTPSSPEEEDK CCHHCCCCCHHHHHH	59.62	25521595
235	Phosphorylation	EIVSTPSSPEEEDKS CHHCCCCCHHHHHHH	37.22	25521595
242	Phosphorylation	SPEEEDKSILNAAVL CHHHHHHHHHHHHHC	44.63	23649490

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBX2B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBX2B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBX2B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of UBX2B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-235, AND MASSSPECTROMETRY.
PubMed: 15345747