UBP4_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBP4_RAT
• UniProt AC: B2GUZ1
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 4
• Gene Name: Usp4
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 961
• Subcellular Localization: Cytoplasm . Nucleus . Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucle
• Protein Description: Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER..
• Protein Sequence: MAEGRGTHERPDVETQKTELGALMGTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRKVVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERETRLWNKYMSNTYEQLSKLDNTIQDAGLYQGQVLVIEPQNEDGTWPRQTLQSKSSTAPSRNFTTSSKPSASPYSSMSASLIANGDSTNSSGMHNSGVSRGGAGFSASYNCQEPPSPHIQPGLCGLGNLGNTCFMNSALQCLSNTGPLTEYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDTHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFILDGLHEDLNRVKKKPYLEPKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRIMEVFLVPADPHCRPIQYRVTVPLMGAISDLCEALSKLSGIAAENMVVTDVYNHRFHKIFQMDEGLSHITPRDDIFVYEICTTPMDGSEYITLPVYFREKKSRPSSTSSGAVLYGQPLLVSVPKHRLTLESLYQAVCERISRYIKQPLPEEFLSSPLEPGACNGSRGSYEGDEEEMDHQEEGKEQLSEVEESGEDSQGGDPTETTQKAKGPPRHKRLFTFSLVNSCGTADINSLATDGKLLKLNSRSTLAIDWDSETRSLYFDEQESEACEKHTSMSQPQKKKKAAIALRECIELFTTMETLGEHDPWYCPTCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPVRALNMSEFVCDRAARPYVYDLIAVSNHYGAMGVGHYTAYAKNRLNGKWYYFDDSSVSLASEDQIVTKAAYVLFYQRRDDECPSTSSPVSFPGSDGGAKLSSSQQDLGEEEAYTMDTN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
445	Phosphorylation	NHRLRNDSVIVDTFH HCCCCCCCEEEECCC	19.79	23984901
641	Phosphorylation	PLPEEFLSSPLEPGA CCCHHHHCCCCCCCC	34.92	22108457
655	Phosphorylation	ACNGSRGSYEGDEEE CCCCCCCCCCCCHHH	20.92	22673903
656	Phosphorylation	CNGSRGSYEGDEEEM CCCCCCCCCCCHHHC	27.10	30181290
674	Phosphorylation	EEGKEQLSEVEESGE HHHHHHHHHHHHHCC	39.01	29779826
679	Phosphorylation	QLSEVEESGEDSQGG HHHHHHHHCCCCCCC	33.70	28689409
683	Phosphorylation	VEESGEDSQGGDPTE HHHHCCCCCCCCCCH	26.82	28689409
835	Ubiquitination	YNRYWRDKLDTVVEF CCHHHHHHCCEEEEC	39.42	-
927	Phosphorylation	RRDDECPSTSSPVSF CCCCCCCCCCCCCCC	53.21	27097102
928	Phosphorylation	RDDECPSTSSPVSFP CCCCCCCCCCCCCCC	20.54	27097102
929	Phosphorylation	DDECPSTSSPVSFPG CCCCCCCCCCCCCCC	36.66	27097102
930	Phosphorylation	DECPSTSSPVSFPGS CCCCCCCCCCCCCCC	29.43	27097102
933	Phosphorylation	PSTSSPVSFPGSDGG CCCCCCCCCCCCCCC	29.16	27097102
937	Phosphorylation	SPVSFPGSDGGAKLS CCCCCCCCCCCCCCC	33.06	28689409
944	Phosphorylation	SDGGAKLSSSQQDLG CCCCCCCCCCCCCCC	27.51	27097102
945	Phosphorylation	DGGAKLSSSQQDLGE CCCCCCCCCCCCCCC	42.47	27097102
946	Phosphorylation	GGAKLSSSQQDLGEE CCCCCCCCCCCCCCC	28.60	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBP4_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBP4_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBP4_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of UBP4_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.