UBP4_MOUSE - dbPTM
UBP4_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UBP4_MOUSE
UniProt AC P35123
Protein Name Ubiquitin carboxyl-terminal hydrolase 4
Gene Name Usp4
Organism Mus musculus (Mouse).
Sequence Length 962
Subcellular Localization Cytoplasm . Nucleus . Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor.
Protein Description Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER..
Protein Sequence MAEGRGSRERPDVETQKTELGALMGTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPAEAWNKLLNWYGCVEGQQPIVRKVVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERETRLWNKYMSNTYEQLSKLDNTIQDAGLYQGQVLVIEPQNEDGTWPRQSLQSKSSTAPSRNFTTSSKPSASPYCSVSASLIANGDSTNSSGMHSSGVSRGGSGFSASYNCQEPPSPHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTEYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDTHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFILDGLHEDLNRVKKKPYLEPKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRIMEVFLVPADPQCRPIQYRVTVPLMGAISDLCEALSKLSGIAAENMVVTDVYNHRFHKIFQMDEGLSHITPRDDIFVYEVCNTSMDGSECITLPVYFREKKSRPSSASSGAVLYGQPLLVSVPKHKLTLESLYQAVCDRISRYIKQPLPDEFLSSPLEPGACNGSRSSYEGDEEEEMDHQEEGKEQLSEVEGSGEDDQGDDHSESAQKVKGQPRHKRLFTFSLVNSCGTADINSLATDGKLLKLNSRSTLAIDWDSETRSLYFDEQESEACEKHLSMSQPQKKKKAAVALRECIELFTTMETLGEHDPWYCPTCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPVRALNMSEFVCDRSARPYVYDLIAVSNHYGAMGVGHYTAYAKNRLNGKWYYFDDSSVSLASEDQIVTKAAYVLFYQRRDDECSSTSSLGSFPGSDGGVKLSSSHQGMGDEEAYNMDTN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
167AcetylationDTIATIEKEMRKLFN
CHHHHHHHHHHHHHC		53.6223806337
186UbiquitinationRETRLWNKYMSNTYE
HHHHHHHHHHHCHHH		30.6522790023
189PhosphorylationRLWNKYMSNTYEQLS
HHHHHHHHCHHHHHH		23.9529514104
192PhosphorylationNKYMSNTYEQLSKLD
HHHHHCHHHHHHCCC		13.11-
232MalonylationPRQSLQSKSSTAPSR
CCHHHCCCCCCCCCC		35.1526320211
232UbiquitinationPRQSLQSKSSTAPSR
CCHHHCCCCCCCCCC		35.15-
234PhosphorylationQSLQSKSSTAPSRNF
HHHCCCCCCCCCCCC		32.1225338131
376UbiquitinationHVAPRMFKTQVGRFA
CCCCHHHHHCCCCCC		28.8022790023
445PhosphorylationNHRLRNDSVIVDTFH
HCCCCCCCEEEECCC		19.7922817900
476PhosphorylationVTFDPFCYLTLPLPL
EEECCCEEEEECCCC		11.78-
588UbiquitinationPVYFREKKSRPSSAS
EEEEEECCCCCCCCC		47.1222790023
589PhosphorylationVYFREKKSRPSSASS
EEEEECCCCCCCCCC		61.5625293948
592PhosphorylationREKKSRPSSASSGAV
EECCCCCCCCCCCCE		37.1125293948
593PhosphorylationEKKSRPSSASSGAVL
ECCCCCCCCCCCCEE		34.5525293948
595PhosphorylationKSRPSSASSGAVLYG
CCCCCCCCCCCEEEC		31.1125293948
596PhosphorylationSRPSSASSGAVLYGQ
CCCCCCCCCCEEECC		30.4125293948
624S-palmitoylationESLYQAVCDRISRYI
HHHHHHHHHHHHHHH		3.0528526873
641PhosphorylationPLPDEFLSSPLEPGA
CCCHHHHCCCCCCCC		34.9225293948
642PhosphorylationLPDEFLSSPLEPGAC
CCHHHHCCCCCCCCC		35.3325293948
652PhosphorylationEPGACNGSRSSYEGD
CCCCCCCCCCCCCCC		18.2626745281
654PhosphorylationGACNGSRSSYEGDEE
CCCCCCCCCCCCCHH		38.6825521595
655PhosphorylationACNGSRSSYEGDEEE
CCCCCCCCCCCCHHH		26.5425521595
656PhosphorylationCNGSRSSYEGDEEEE
CCCCCCCCCCCHHHH		25.7723737553
675PhosphorylationEEGKEQLSEVEGSGE
HHHHHHHHHCCCCCC		39.0125521595
680PhosphorylationQLSEVEGSGEDDQGD
HHHHCCCCCCCCCCC		26.0425521595
690PhosphorylationDDQGDDHSESAQKVK
CCCCCCCCHHHHHHC		40.0022324799
692PhosphorylationQGDDHSESAQKVKGQ
CCCCCCHHHHHHCCC		38.7325521595
695UbiquitinationDHSESAQKVKGQPRH
CCCHHHHHHCCCCCC		45.7022790023
724PhosphorylationADINSLATDGKLLKL
CCHHHHHCCCCEEEE		51.05-
730UbiquitinationATDGKLLKLNSRSTL
HCCCCEEEECCCCCE		56.9322790023
769UbiquitinationLSMSQPQKKKKAAVA
HCCCCCHHHHHHHHH		73.5622790023
810UbiquitinationKHQQATKKFDLWSLP
HHHHCCCCCCCCCCC		39.4922790023
815PhosphorylationTKKFDLWSLPKILVV
CCCCCCCCCCEEEEE		41.9320495213
836UbiquitinationYNRYWRDKLDTVVEF
CCHHHHHHCCEEEEC		39.4222790023
858PhosphorylationSEFVCDRSARPYVYD
HHHHCCCCCCCCEEH		18.5125367039
862PhosphorylationCDRSARPYVYDLIAV
CCCCCCCCEEHEEEE		13.1925367039
864PhosphorylationRSARPYVYDLIAVSN
CCCCCCEEHEEEEEC		10.1325367039
870PhosphorylationVYDLIAVSNHYGAMG
EEHEEEEECCCCCCC		14.6325367039
873PhosphorylationLIAVSNHYGAMGVGH
EEEEECCCCCCCCCH		15.7225367039
881PhosphorylationGAMGVGHYTAYAKNR
CCCCCCHHHHEEECC		6.2725367039
882PhosphorylationAMGVGHYTAYAKNRL
CCCCCHHHHEEECCC		13.9125367039
884PhosphorylationGVGHYTAYAKNRLNG
CCCHHHHEEECCCCC		15.4325367039
945PhosphorylationSDGGVKLSSSHQGMG
CCCCEECCCCCCCCC		24.8725159016
946PhosphorylationDGGVKLSSSHQGMGD
CCCEECCCCCCCCCC		42.1321082442
947PhosphorylationGGVKLSSSHQGMGDE
CCEECCCCCCCCCCH		19.2225159016
957PhosphorylationGMGDEEAYNMDTN--
CCCCHHHCCCCCC--		17.8225159016
961PhosphorylationEEAYNMDTN------
HHHCCCCCC------		31.8725159016
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
-KUbiquitinationE3 ubiquitin ligaseTrim21Q62191
PMID:22199232
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UBP4_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UBP4_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of UBP4_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UBP4_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-680, AND MASSSPECTROMETRY.

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