UBP47_MOUSE - dbPTM
UBP47_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UBP47_MOUSE
UniProt AC Q8BY87
Protein Name Ubiquitin carboxyl-terminal hydrolase 47
Gene Name Usp47
Organism Mus musculus (Mouse).
Sequence Length 1376
Subcellular Localization Cytoplasm.
Protein Description Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER) (By similarity). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level..
Protein Sequence MVPGEENQLVPKEDVFWRCRQNIFDEMKKKFLQIENAAEEPRVLCIIQDTTNSKTVSERITLNLPASTPVRKLFEDVANKVGYINGTFDLTRENGVTTADMAPLDHTSDKSLLDANFEPGKKNFLHLTDKDGEPPQMLLEDSNNVDDSVHDRFIGPLPREGSVASTNDYVSQNYSYSSILNKSETGYVGLVNQAMTCYLNSLLQTLFMTPEFRNALYKWEFEDSEEDPVTSIPYQLQRLFVLLQTSKKRAIETTDVTRSFGWDSSEAWQQHDVQELCRVMFDALEQKWKQTEQADLINELYQGKLKDYVRCLECGYEGWRIDTYLDIPLVIRPYGSSQAFASVEEALHAFIQPEILDGPNQYFCERCKKKCDARKGLRFLHFPYLLTLQLKRFDFDYTTMHRIKLNDRMSFPEELDMSTFIDIEDEKSPQTESCTDSGAENEGSCHSDQMSNDFSTDDAVDEGICLESSSGSEKISKPGLEKNSLMYELFSVMVHSGSAAGGHYYACIKSFSDDQWYSFNDQHVSRITQEDIKKTHGGSSGSRGYYSSAFASSTNAYMLIYRLKDPTRNAKFLEVDEYPEHIKNLVQKERELEEQEKRQREIERNTCKIKLFCLHPVKQVMMENKLEVHKDKTLKEAVEMAYKMMDLEDVIPLDCCRLVKYDEFHDYLERSYEGEEDTPMGLLLGGVKSTYMFDLLLETRKPDQIFQSYKPGEVMVKVHVVDLKAETVAAPVTVRAYLNQTVTEFKQLISKATHLPADSMRIVLERCYNDLRLLSMPSKTLKAEGFFRSNKVFVESSETVDHQAAFTDSHLWKLLDRHANTIRLFVLLPEQSPGSYSKRTAYQKAGGDSGNVDDDCERVKGPAGNLKSVDAILEESTEKLKSLSLQQQQQDGDNGDSSKSTETSDFENIESPLNERGSSTSVDNRELEQHIQTSDPENFQSEERSDSDVNNDRSTSSVDSDILSSSHSSDTLCNADSAQIPLANGLDSHSITSSRRTKANEGKKETWDTAEEDSGTDSEYDESGKSRGDMQYMYFKADPYTADEGSGEGHKWLMVHVDKRITLAAFKQHLEPFVGVLSSHFKVFRVYTSNQEFETVRLNETLSSFSDDNKITIRLGRALKKGEYRVKVCQLLVNEQEPCKFLLDAVFAKGMTVRQSKEELIPQLREQCGLDLSIDRFRLRKKTWKNPGTVFLDYHIYEEDINISSNWEVFLEVLDGVEKMKSMSQLAILTRRWRPAEMKLDPFQELVLESNSVDELREKLSEISGIPLEDIEFAKGRGTFPCDISVLDIHQDLDWNPKVSTLNVWPLYICDDGAVIFYRDRTEEVMELTDEQRNELMKKESSRLQKTGHRVTYSPRKEKALKIYLDGAPNKDVAQD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
111PhosphorylationLDHTSDKSLLDANFE
CCCCCCCHHHHCCCC		38.8728973931
122AcetylationANFEPGKKNFLHLTD
CCCCCCCCCEEEEEC		59.8723954790
148PhosphorylationDSNNVDDSVHDRFIG
CCCCCCCCCHHCCCC		19.52-
162PhosphorylationGPLPREGSVASTNDY
CCCCCCCCCCCCCCC		15.1230352176
165PhosphorylationPREGSVASTNDYVSQ
CCCCCCCCCCCCCCC		26.1129899451
174PhosphorylationNDYVSQNYSYSSILN
CCCCCCCCCHHHHCC		11.0129514104
287UbiquitinationMFDALEQKWKQTEQA
HHHHHHHHHHHHHHH		47.1622790023
304UbiquitinationINELYQGKLKDYVRC
HHHHHHCCHHHHHHH		36.5222790023
384PhosphorylationLRFLHFPYLLTLQLK
CHHHCHHHHEEEECC		17.2522871156
384UbiquitinationLRFLHFPYLLTLQLK
CHHHCHHHHEEEECC		17.2527667366
404UbiquitinationYTTMHRIKLNDRMSF
CCEEEEEECCCCCCC		40.9927667366
457UbiquitinationMSNDFSTDDAVDEGI
CCCCCCCCCCCCCCC		40.4527667366
477UbiquitinationSGSEKISKPGLEKNS
CCCCCCCCCCCCCCC		46.7227667366
528PhosphorylationDQHVSRITQEDIKKT
HHHHHHCCHHHHHHH		25.4620531401
608AcetylationEIERNTCKIKLFCLH
HHHHHHHHEEEEECC		40.6219847661
610AcetylationERNTCKIKLFCLHPV
HHHHHHEEEEECCHH		22.4722826441
688AcetylationGLLLGGVKSTYMFDL
HHCCCCCCHHHHHHH		40.1119857889
710AcetylationDQIFQSYKPGEVMVK
HHHHCCCCCCCEEEE		52.3623236377
782UbiquitinationSMPSKTLKAEGFFRS
CCCCCCCCEECCCCC		50.0122790023
812 (in isoform 2)Phosphorylation-5.4824719451
832PhosphorylationFVLLPEQSPGSYSKR
EEECCCCCCCCCCCC		29.5724925903
835PhosphorylationLPEQSPGSYSKRTAY
CCCCCCCCCCCCCCH		29.6228833060
836PhosphorylationPEQSPGSYSKRTAYQ
CCCCCCCCCCCCCHH		24.9128833060
837PhosphorylationEQSPGSYSKRTAYQK
CCCCCCCCCCCCHHH		19.8428833060
838UbiquitinationQSPGSYSKRTAYQKA
CCCCCCCCCCCHHHC		45.6022790023
849PhosphorylationYQKAGGDSGNVDDDC
HHHCCCCCCCCCCCC		35.2325521595
868PhosphorylationGPAGNLKSVDAILEE
CCCCCCHHHHHHHHH		28.5325521595
876PhosphorylationVDAILEESTEKLKSL
HHHHHHHHHHHHHHC		32.2730352176
877PhosphorylationDAILEESTEKLKSLS
HHHHHHHHHHHHHCC		40.1830352176
879UbiquitinationILEESTEKLKSLSLQ
HHHHHHHHHHHCCHH		62.3922790023
882PhosphorylationESTEKLKSLSLQQQQ
HHHHHHHHCCHHHHH		33.36-
884PhosphorylationTEKLKSLSLQQQQQD
HHHHHHCCHHHHHHC		31.0922807455
897PhosphorylationQDGDNGDSSKSTETS
HCCCCCCCCCCCCCC		40.8519060867
898PhosphorylationDGDNGDSSKSTETSD
CCCCCCCCCCCCCCC		35.0525293948
900PhosphorylationDNGDSSKSTETSDFE
CCCCCCCCCCCCCCC		33.1625619855
901PhosphorylationNGDSSKSTETSDFEN
CCCCCCCCCCCCCCC		47.2025619855
903PhosphorylationDSSKSTETSDFENIE
CCCCCCCCCCCCCCC		33.4125619855
904PhosphorylationSSKSTETSDFENIES
CCCCCCCCCCCCCCC		33.7925619855
911PhosphorylationSDFENIESPLNERGS
CCCCCCCCCCCCCCC		30.7825521595
918PhosphorylationSPLNERGSSTSVDNR
CCCCCCCCCCCCCHH		36.3425293948
919PhosphorylationPLNERGSSTSVDNRE
CCCCCCCCCCCCHHH		27.7625266776
920PhosphorylationLNERGSSTSVDNREL
CCCCCCCCCCCHHHH		34.1719060867
921PhosphorylationNERGSSTSVDNRELE
CCCCCCCCCCHHHHH		29.4419060867
933PhosphorylationELEQHIQTSDPENFQ
HHHHHHCCCCCCCCC		34.2027742792
934PhosphorylationLEQHIQTSDPENFQS
HHHHHCCCCCCCCCC		34.4925521595
941PhosphorylationSDPENFQSEERSDSD
CCCCCCCCCCCCCCC		36.9725619855
945PhosphorylationNFQSEERSDSDVNND
CCCCCCCCCCCCCCC		44.7521183079
947PhosphorylationQSEERSDSDVNNDRS
CCCCCCCCCCCCCCC		44.7125521595
954PhosphorylationSDVNNDRSTSSVDSD
CCCCCCCCCCCCCHH		35.1923984901
955PhosphorylationDVNNDRSTSSVDSDI
CCCCCCCCCCCCHHH		26.3923984901
956PhosphorylationVNNDRSTSSVDSDIL
CCCCCCCCCCCHHHH		29.6123984901
957PhosphorylationNNDRSTSSVDSDILS
CCCCCCCCCCHHHHH		29.9923984901
960PhosphorylationRSTSSVDSDILSSSH
CCCCCCCHHHHHCCC		25.1323984901
964PhosphorylationSVDSDILSSSHSSDT
CCCHHHHHCCCCCCC		30.0819060867
965PhosphorylationVDSDILSSSHSSDTL
CCHHHHHCCCCCCCC		28.7323984901
966PhosphorylationDSDILSSSHSSDTLC
CHHHHHCCCCCCCCC		24.8223984901
968PhosphorylationDILSSSHSSDTLCNA
HHHHCCCCCCCCCCC		31.6823984901
969PhosphorylationILSSSHSSDTLCNAD
HHHCCCCCCCCCCCC		29.2323984901
971PhosphorylationSSSHSSDTLCNADSA
HCCCCCCCCCCCCCC		34.8523984901
977PhosphorylationDTLCNADSAQIPLAN
CCCCCCCCCCCCCCC		21.4723984901
988PhosphorylationPLANGLDSHSITSSR
CCCCCCCCCCCCCCC		24.9523984901
990PhosphorylationANGLDSHSITSSRRT
CCCCCCCCCCCCCCC		31.3623984901
992PhosphorylationGLDSHSITSSRRTKA
CCCCCCCCCCCCCCC		24.5423984901
993PhosphorylationLDSHSITSSRRTKAN
CCCCCCCCCCCCCCC		21.8523984901
994PhosphorylationDSHSITSSRRTKANE
CCCCCCCCCCCCCCC		19.6823984901
1006PhosphorylationANEGKKETWDTAEED
CCCCCCCCCCCCCCC		37.2028507225
1009PhosphorylationGKKETWDTAEEDSGT
CCCCCCCCCCCCCCC		27.7722324799
1014PhosphorylationWDTAEEDSGTDSEYD
CCCCCCCCCCCCCCC		47.0425521595
1016PhosphorylationTAEEDSGTDSEYDES
CCCCCCCCCCCCCCC		40.0625521595
1018PhosphorylationEEDSGTDSEYDESGK
CCCCCCCCCCCCCCC		37.5827087446
1020PhosphorylationDSGTDSEYDESGKSR
CCCCCCCCCCCCCCC		29.0322324799
1023PhosphorylationTDSEYDESGKSRGDM
CCCCCCCCCCCCCCC		48.9325293948
1026PhosphorylationEYDESGKSRGDMQYM
CCCCCCCCCCCCEEE		45.0525521595
1089PhosphorylationKVFRVYTSNQEFETV
EEEEEECCCCCEEEE		20.8725338131
1095PhosphorylationTSNQEFETVRLNETL
CCCCCEEEEEECCCH		19.0830482847
1222PhosphorylationDGVEKMKSMSQLAIL
HHHHHHHHHHHHHHH		21.8425338131
1252PhosphorylationELVLESNSVDELREK
HHHHHCCCHHHHHHH		39.9821743459
1275UbiquitinationLEDIEFAKGRGTFPC
HHHCCCCCCCCCCCC		55.2322790023
1352PhosphorylationQKTGHRVTYSPRKEK
HHHCCCCCCCCCHHH		20.4525367039
1353PhosphorylationKTGHRVTYSPRKEKA
HHCCCCCCCCCHHHH		17.5121454597
1354PhosphorylationTGHRVTYSPRKEKAL
HCCCCCCCCCHHHHH		14.6326824392
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UBP47_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UBP47_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UBP47_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of UBP47_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UBP47_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-911, AND MASSSPECTROMETRY.
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1016, AND MASSSPECTROMETRY.

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