UBP40_HUMAN - dbPTM
UBP40_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID UBP40_HUMAN
UniProt AC Q9NVE5
Protein Name Ubiquitin carboxyl-terminal hydrolase 40
Gene Name USP40
Organism Homo sapiens (Human).
Sequence Length 1235
Subcellular Localization
Protein Description May be catalytically inactive..
Protein Sequence MFGDLFEEEYSTVSNNQYGKGKKLKTKALEPPAPREFTNLSGIRNQGGTCYLNSLLQTLHFTPEFREALFSLGPEELGLFEDKDKPDAKVRIIPLQLQRLFAQLLLLDQEAASTADLTDSFGWTSNEEMRQHDVQELNRILFSALETSLVGTSGHDLIYRLYHGTIVNQIVCKECKNVSERQEDFLDLTVAVKNVSGLEDALWNMYVEEEVFDCDNLYHCGTCDRLVKAAKSAKLRKLPPFLTVSLLRFNFDFVKCERYKETSCYTFPLRINLKPFCEQSELDDLEYIYDLFSVIIHKGGCYGGHYHVYIKDVDHLGNWQFQEEKSKPDVNLKDLQSEEEIDHPLMILKAILLEENNLIPVDQLGQKLLKKIGISWNKKYRKQHGPLRKFLQLHSQIFLLSSDESTVRLLKNSSLQAESDFQRNDQQIFKMLPPESPGLNNSISCPHWFDINDSKVQPIREKDIEQQFQGKESAYMLFYRKSQLQRPPEARANPRYGVPCHLLNEMDAANIELQTKRAECDSANNTFELHLHLGPQYHFFNGALHPVVSQTESVWDLTFDKRKTLGDLRQSIFQLLEFWEGDMVLSVAKLVPAGLHIYQSLGGDELTLCETEIADGEDIFVWNGVEVGGVHIQTGIDCEPLLLNVLHLDTSSDGEKCCQVIESPHVFPANAEVGTVLTALAIPAGVIFINSAGCPGGEGWTAIPKEDMRKTFREQGLRNGSSILIQDSHDDNSLLTKEEKWVTSMNEIDWLHVKNLCQLESEEKQVKISATVNTMVFDIRIKAIKELKLMKELADNSCLRPIDRNGKLLCPVPDSYTLKEAELKMGSSLGLCLGKAPSSSQLFLFFAMGSDVQPGTEMEIVVEETISVRDCLKLMLKKSGLQGDAWHLRKMDWCYEAGEPLCEEDATLKELLICSGDTLLLIEGQLPPLGFLKVPIWWYQLQGPSGHWESHQDQTNCTSSWGRVWRATSSQGASGNEPAQVSLLYLGDIEISEDATLAELKSQAMTLPPFLEFGVPSPAHLRAWTVERKRPGRLLRTDRQPLREYKLGRRIEICLEPLQKGENLGPQDVLLRTQVRIPGERTYAPALDLVWNAAQGGTAGSLRQRVADFYRLPVEKIEIAKYFPEKFEWLPISSWNQQITKRKKKKKQDYLQGAPYYLKDGDTIGVKNLLIDDDDDFSTIRDDTGKEKQKQRALGRRKSQEALHEQSSYILSSAETPARPRAPETSLSIHVGSFR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
10PhosphorylationGDLFEEEYSTVSNNQ
CCCCCHHHCCCCCCC		16.9627642862
11PhosphorylationDLFEEEYSTVSNNQY
CCCCHHHCCCCCCCC		26.1327642862
12PhosphorylationLFEEEYSTVSNNQYG
CCCHHHCCCCCCCCC		27.3527642862
14PhosphorylationEEEYSTVSNNQYGKG
CHHHCCCCCCCCCCC		30.1027642862
41PhosphorylationPREFTNLSGIRNQGG
CCCCCCCCCCCCCCC		33.9524719451
413PhosphorylationTVRLLKNSSLQAESD
HHHHHHCCCCCCCCH		30.7325850435
414PhosphorylationVRLLKNSSLQAESDF
HHHHHCCCCCCCCHH		33.6225850435
436PhosphorylationFKMLPPESPGLNNSI
HHHCCCCCCCCCCCC		30.0028188228
442PhosphorylationESPGLNNSISCPHWF
CCCCCCCCCCCCCEE		18.1425850435
444PhosphorylationPGLNNSISCPHWFDI
CCCCCCCCCCCEEEC		22.7825002506
448PhosphorylationNSISCPHWFDINDSK
CCCCCCCEEECCCCC		4.2624719451
474UbiquitinationQFQGKESAYMLFYRK
HHCCCHHHHHHHHCH		8.54-
571PhosphorylationTLGDLRQSIFQLLEF
CHHHHHHHHHHHHHH		20.9517192257
586PhosphorylationWEGDMVLSVAKLVPA
HCCCCHHHHHHHHCC		14.4924719451
733PhosphorylationQDSHDDNSLLTKEEK
ECCCCCCCCCCCHHH		31.5824719451
736PhosphorylationHDDNSLLTKEEKWVT
CCCCCCCCCHHHHCC		41.52-
776UbiquitinationSATVNTMVFDIRIKA
EEEECCCHHHHHHHH		3.52-
819UbiquitinationVPDSYTLKEAELKMG
CCCCCCCCHHHHHCC		47.2629967540
827PhosphorylationEAELKMGSSLGLCLG
HHHHHCCCCCCHHCC		20.92-
828PhosphorylationAELKMGSSLGLCLGK
HHHHCCCCCCHHCCC		22.26-
831UbiquitinationKMGSSLGLCLGKAPS
HCCCCCCHHCCCCCC		2.36-
850PhosphorylationFLFFAMGSDVQPGTE
EEEHHCCCCCCCCCE		22.86-
960PhosphorylationDQTNCTSSWGRVWRA
CCCCCCCCHHHEEEE		18.5224275569
1156PhosphorylationDYLQGAPYYLKDGDT
HHHCCCCEECCCCCE		22.39-
1157PhosphorylationYLQGAPYYLKDGDTI
HHCCCCEECCCCCEE		13.25-
1199PhosphorylationRALGRRKSQEALHEQ
HHHHHHHHHHHHHHC		31.2930266825
1207PhosphorylationQEALHEQSSYILSSA
HHHHHHCCCHHHHCC		23.3230266825
1208PhosphorylationEALHEQSSYILSSAE
HHHHHCCCHHHHCCC		18.8428464451
1209PhosphorylationALHEQSSYILSSAET
HHHHCCCHHHHCCCC		15.8928464451
1211PhosphorylationHEQSSYILSSAETPA
HHCCCHHHHCCCCCC		2.2224719451
1212PhosphorylationEQSSYILSSAETPAR
HCCCHHHHCCCCCCC		20.2423927012
1213PhosphorylationQSSYILSSAETPARP
CCCHHHHCCCCCCCC		27.0323927012
1216PhosphorylationYILSSAETPARPRAP
HHHHCCCCCCCCCCC		23.2023927012
1226PhosphorylationRPRAPETSLSIHVGS
CCCCCCCCEEEEEEC		20.6128555341
1233PhosphorylationSLSIHVGSFR-----
CEEEEEECCC-----		19.4327251275
1245Phosphorylation-----------------
-----------------		27251275
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of UBP40_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of UBP40_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of UBP40_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of UBP40_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of UBP40_HUMAN

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Related Literatures of Post-Translational Modification

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