UBP3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBP3_MOUSE
• UniProt AC: Q91W36
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 3
• Gene Name: Usp3
• Organism: Mus musculus (Mouse).
• Sequence Length: 520
• Subcellular Localization: Nucleus. Localizes preferentially with monoubiquitinated H2A to chromatin.
• Protein Description: Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin (By similarity)..
• Protein Sequence: MECPHLSSSVCIAPDSAKFPNGSPSSWCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQIPLLNHKRSEKQEKAQHTVCMDCSSYSTYCYRCDDFVVNDTKLGLVQKVREHLQNLENSAFTADRHRKRKLLENSSLNSKLLKVNGSTTAICATGLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDSNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLSASNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFDPFLDLSLDIPSQFRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKALCLHLKRFHWTAYLRNKVDTYVQFPLRGLDMKCYLLEPENSGPDSCLYDLAAVVVHHGSGVGSGHYTAYAVHEGRWFHFNDSTVTVTDEETVGKAKAYILFYVERQARAGAEKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MECPHLSS -------CCCCCCCC	12.34	-
135	Ubiquitination	ADRHRKRKLLENSSL CHHHHHHHHHHCCCC	61.53	22790023
140	Phosphorylation	KRKLLENSSLNSKLL HHHHHHCCCCCCEEE	27.16	29176673
141	Phosphorylation	RKLLENSSLNSKLLK HHHHHCCCCCCEEEE	43.05	29176673
145	Ubiquitination	ENSSLNSKLLKVNGS HCCCCCCEEEEECCC	57.68	22790023
210	Phosphorylation	RRTYHTRSQGDSNVS CCCEECCCCCCCCCH	39.40	25338131
423	Ubiquitination	WTAYLRNKVDTYVQF HHHHHHCCCCEEEEE	34.75	22790023
427	Phosphorylation	LRNKVDTYVQFPLRG HHCCCCEEEEEECCC	6.44	20047950

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBP3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBP3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBP3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of UBP3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.