UBP25_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBP25_MOUSE
• UniProt AC: P57080
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 25
• Gene Name: Usp25
• Organism: Mus musculus (Mouse).
• Sequence Length: 1055
• Subcellular Localization: Cytoplasm . Nucleus . The longer muscle-specific isoform (USP25m) Some transient punctuate nuclear location in myotubes during myocyte development.
• Protein Description: Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains (By similarity).; The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function..
• Protein Sequence: MTVEQNVLQQSAAQKHQQTFLNQLREITGINDAQILQQALKDSNGNLELAVAFLTAKNAKTPPQEETGYYQTALPGNDRYISVGSQADANVIDLTGDDKDDLQRAIALSLAESNRAFRETGITDEEQAISRVLEASIAENKACLKRTPIEVWRDSRNPYDRKRQEKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPRNQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILKDAFKSNDSQQQDVSEFTHKLLDWLEDAFQMKAEEETDEEKPKNPMVELFYGRFLAMGVLEGKKFENTEMFGQYPLQVNGFKDLHECLEAAMIEGEIESLHSDNSGKSGQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRNREITRIKREEIKRLKDYLTVLQQRLERYLSYGSGPKRFPLVDVLQYALEFASSKPVCTSPVDDIDASSSASGPLPSQSLPSTTEQQGPCASDLPGSSSPASGAALPLRSVIHKPFTQSRIPPDLPMHPAPRHITEEELCVLESCLHRWRTEIENDTRDLQESISRIHRTIELMYSDKSMIQVPYRLHAVLVHEGQANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASAYCLMYIDDKAQFLIQEEFNKETGQALVGMETLPPDLRDFVEEDNQRFEKELEEWDTQLAQRSLQEKLLAAPKLREAEASATTAQAGGADYLEQPSRSDLSKHWKEETLRVIAKASHDLEDKGPETVLQSAIKLEYSRLVKLAQEDTPPETDYRLHHVLVYFIQNQAPKKIIEKTLLEQFGDRNLSFDERCHNIMKVAQAKLEMIKPEEVNLEEYEEWHADYKKFRETTMYLITGLENFQRESYIDSLLFLLCAYQNNKELLSKGPYRGHDGELISHYRRECLLKLNEQAAELFESGEDGDVNNGLIIMNEFIVPFLPLLLVDDMEEKDILAVEDMRNRWCSYLGQEMEANLQEKLTDFLPKLLDCSTEIKGFHEPPKLPSYSAHELCERFARIMLSLSRTPADGR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTVEQNVLQ ------CCHHHHHHH	44.01	25338131
41	Ubiquitination	QILQQALKDSNGNLE HHHHHHHHCCCCCHH	63.23	-
57	Ubiquitination	AVAFLTAKNAKTPPQ EEEHHHHCCCCCCCH	52.80	22790023
61	Phosphorylation	LTAKNAKTPPQEETG HHHCCCCCCCHHHCC	37.48	25521595
67	Phosphorylation	KTPPQEETGYYQTAL CCCCHHHCCCCCCCC	29.72	25293948
69	Phosphorylation	PPQEETGYYQTALPG CCHHHCCCCCCCCCC	10.38	25293948
70	Phosphorylation	PQEETGYYQTALPGN CHHHCCCCCCCCCCC	10.75	25367039
82	Phosphorylation	PGNDRYISVGSQADA CCCCCEEEECCCCCC	16.10	20531401
85	Phosphorylation	DRYISVGSQADANVI CCEEEECCCCCCCEE	21.75	20531401
99	Ubiquitination	IDLTGDDKDDLQRAI EECCCCCHHHHHHHH	58.86	-
201	Ubiquitination	RRLVLNYKPPSNAQD HHHHHHCCCCCCCCC	49.75	22790023
250	Ubiquitination	SRAVEILKDAFKSND HHHHHHHHHHHHCCC	53.31	22790023
254	Ubiquitination	EILKDAFKSNDSQQQ HHHHHHHHCCCHHCC	50.50	22790023
286	Phosphorylation	QMKAEEETDEEKPKN HHHHHHCCCCCCCCC	52.57	27180971
312	Ubiquitination	AMGVLEGKKFENTEM HHHHHCCCCEECCCC	44.93	22790023
313	Ubiquitination	MGVLEGKKFENTEMF HHHHCCCCEECCCCC	69.62	22790023
392	Ubiquitination	RPEKIHNKLEFPQVL CCHHHHCCCCCCCHH	34.92	22790023
425	Phosphorylation	EIKRLKDYLTVLQQR HHHHHHHHHHHHHHH	11.59	-
427	Phosphorylation	KRLKDYLTVLQQRLE HHHHHHHHHHHHHHH	16.97	-
444	Ubiquitination	LSYGSGPKRFPLVDV HHCCCCCCCCCHHHH	70.92	22790023
521	Ubiquitination	PLRSVIHKPFTQSRI CHHHHCCCCCCCCCC	30.60	22790023
585	Ubiquitination	IELMYSDKSMIQVPY HHHHHCCCCCCCCCE	35.66	22790023
623	Ubiquitination	HRESRWMKYNDIAVT CCCCCCCCCCCEEEE	33.66	22790023
631	Ubiquitination	YNDIAVTKSSWEELV CCCEEEEHHHHHHHH	35.57	22790023
681	Phosphorylation	QALVGMETLPPDLRD CEEEECCCCCCCHHH	35.35	21189417
699	Ubiquitination	EDNQRFEKELEEWDT HHHHHHHHHHHHHHH	65.96	22790023
716	Ubiquitination	AQRSLQEKLLAAPKL HHHHHHHHHHHCHHH	35.52	22790023
722	Ubiquitination	EKLLAAPKLREAEAS HHHHHCHHHHHHHHH	56.29	22790023
722	Acetylation	EKLLAAPKLREAEAS HHHHHCHHHHHHHHH	56.29	22902405
740	Phosphorylation	AQAGGADYLEQPSRS CCCCCCCCCCCCCHH	16.17	25159016
790	Ubiquitination	LEYSRLVKLAQEDTP HHHHHHHHHHHCCCC	42.57	22790023
1011	Ubiquitination	KLTDFLPKLLDCSTE HHHHHHHHHHCCCCC	64.92	22790023

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBP25_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBP25_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBP25_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of UBP25_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.