UBN2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBN2_MOUSE
• UniProt AC: Q80WC1
• Protein Name: Ubinuclein-2
• Gene Name: Ubn2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1314
• Protein Sequence: MAEPRRVAFISLSPVRRREADFAGAEREPPRLEPQPYREPARAEPAPRADAQPPARDKPLPQREVSRAEPPMALQREPPRPEPPPPPLPLQTPPPRESASRAEPPPRPPKETVRLELVLKDPTDESCVEFSYPELLLCGEQRKKLVHTEDPFTDEHKERQEVEMLAKKFEMKYGGKARKHRKDRLQDLIDIGFGYDETDPFIDNSEAYDELVPASLTTKYGGFYINTGTLQFRQASDTEEDDFTDNQKHKPPKVPKIKEDDIEVKKRKRKEEGEKEKKPRKKVPKQLGVVALNSHKSEKKKKRYKDSLSLAAMIRKFQKEKDALKKESTPKVPVTPSSSSLPKPPCVTTALGDDIPDLGLNSADPDLPIFVSTNEHELFQEAENALEMLDDFDFDRLLDATSDGSPLSESGGENGNTTHPTFPSQVVPKVVPTLPEGLPVLLEKRIEDLRVAAKLFDEEGRKKFFTQDMNNILLDIELQLQELGPVIRSGVYSHLEAFVPCNKETLVKRLKKLHLNVQDDRLREPLQKLKLAVSNVMPEQLFKYQEDCQARSQAKCAKLQADEEREKNGSDDDDDEKPGKRVIGPRKKFHWDDTIRTLLCNLVEIKLGCYELEPNKSQSAEDYLKSFMETEVKPLWPKGWMQARMLFKESRSVHNHLTSAPAKKKVIPASKPKVKECSPKKDPKAPASVVASGGGPSTSSSTSIVASASSSSAPAQETICLDDSLDEDLSFPSASLDLVSEALAVINNGNKGPSVGSRLNVPTTKPRPGLREEKLASIMSKLPLATPKKLDSTQTAHSSSLIAGHTGPVPKKPQDLAHTGISSGLIAGSSIQNPKVSLEPLPARLLQQGLQRSSQIHASSSSQTHVSSSQAQAAASSHALGTSEAQDASSLTQVTKVHQHSAVQQNYVSPLQATISKSQTNPVVKLSNNPQLSCSSQLLKTSDKPLMYRLPLSTPSPGNGSQGPHPLVSRTAPSTTTSSNYLAKAMVSQISTQGFKSPFSMAASPKLAASPKPATSPKPLPSPKPSVSPKPSLSAKPSISTKQISKSNPAPKPAVCPSSSSPNTLVAQSSHSTSNNPVHKQPSGMNISRQSPTLNLLPSNRTSGLPTTKTLQAPSKLTNSSSTGTAGKNSLSGIPMNVPASRGSNLNSSGANRTSLSGGTGSGTQGATKPLSTPHRPTSASGSSVVTASVQSTAGASLLANASPLTLMTSPLSVTNQTVTPFGMLGGLVPVTMPFQFPLELLGFGTDTAGVTATSGSTSAALHHSLTQNLLKSLQPGAQHAAALPHSPLPAHLQQAFNDGGQSKGDTKLPRKPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	PRRVAFISLSPVRRR CCEEEEEECCCCCCC	19.15	25159016
13	Phosphorylation	RVAFISLSPVRRREA EEEEEECCCCCCCCC	17.98	23527152
227	Phosphorylation	YGGFYINTGTLQFRQ ECCEEEECCEEEEEE	23.22	26643407
229	Phosphorylation	GFYINTGTLQFRQAS CEEEECCEEEEEECC	18.49	26643407
236	Phosphorylation	TLQFRQASDTEEDDF EEEEEECCCCCCCCC	36.41	25521595
238	Phosphorylation	QFRQASDTEEDDFTD EEEECCCCCCCCCCC	38.49	25521595
244	Phosphorylation	DTEEDDFTDNQKHKP CCCCCCCCCCCCCCC	40.82	26643407
265	Acetylation	KEDDIEVKKRKRKEE CHHHHHHHHHHHHHH	33.79	7711939
282	Ubiquitination	KEKKPRKKVPKQLGV HCCCCCCCCCHHHCC	66.12	-
285	Ubiquitination	KPRKKVPKQLGVVAL CCCCCCCHHHCCHHC	62.23	-
296	Ubiquitination	VVALNSHKSEKKKKR CHHCCCCCCHHHHHH	61.19	-
297	Phosphorylation	VALNSHKSEKKKKRY HHCCCCCCHHHHHHH	49.58	-
304	Phosphorylation	SEKKKKRYKDSLSLA CHHHHHHHHHHHHHH	28.20	28059163
307	Phosphorylation	KKKRYKDSLSLAAMI HHHHHHHHHHHHHHH	18.73	28059163
402	Phosphorylation	DRLLDATSDGSPLSE HHHHHCCCCCCCCCC	41.51	22817900
405	Phosphorylation	LDATSDGSPLSESGG HHCCCCCCCCCCCCC	27.88	22817900
408	Phosphorylation	TSDGSPLSESGGENG CCCCCCCCCCCCCCC	32.85	22817900
410	Phosphorylation	DGSPLSESGGENGNT CCCCCCCCCCCCCCC	49.04	25293948
417	Phosphorylation	SGGENGNTTHPTFPS CCCCCCCCCCCCCHH	28.07	28576409
418	Phosphorylation	GGENGNTTHPTFPSQ CCCCCCCCCCCCHHH	29.83	28576409
421	Phosphorylation	NGNTTHPTFPSQVVP CCCCCCCCCHHHHCC	40.34	28576409
570	Phosphorylation	EEREKNGSDDDDDEK HHHHHCCCCCCCCCC	47.46	25266776
617	Phosphorylation	YELEPNKSQSAEDYL EECCCCCCCCHHHHH	35.69	27841257
678	Phosphorylation	KPKVKECSPKKDPKA CCCCCCCCCCCCCCC	40.63	26745281
763	Phosphorylation	GSRLNVPTTKPRPGL CCCCCCCCCCCCCCC	43.07	30482847
780	Phosphorylation	EKLASIMSKLPLATP HHHHHHHHCCCCCCC	29.39	27600695
806	Phosphorylation	SSLIAGHTGPVPKKP CCCCCCCCCCCCCCH	42.11	-
909	Phosphorylation	AVQQNYVSPLQATIS HHHHCCCCCHHHCCC	14.99	-
944	Acetylation	QLLKTSDKPLMYRLP HHHHCCCCCEEEEEE	39.56	23806337
1004	Phosphorylation	SPFSMAASPKLAASP CCCCCCCCCCCCCCC	17.03	26643407
1010	Phosphorylation	ASPKLAASPKPATSP CCCCCCCCCCCCCCC	28.05	28066266
1015	Phosphorylation	AASPKPATSPKPLPS CCCCCCCCCCCCCCC	54.83	28066266
1016	Phosphorylation	ASPKPATSPKPLPSP CCCCCCCCCCCCCCC	32.79	28066266
1026	Phosphorylation	PLPSPKPSVSPKPSL CCCCCCCCCCCCCCC	41.16	28066266
1028	Phosphorylation	PSPKPSVSPKPSLSA CCCCCCCCCCCCCCC	31.38	28066266
1032	Phosphorylation	PSVSPKPSLSAKPSI CCCCCCCCCCCCCCC	40.87	28066266
1034	Phosphorylation	VSPKPSLSAKPSIST CCCCCCCCCCCCCCH	38.29	28066266
1036	Acetylation	PKPSLSAKPSISTKQ CCCCCCCCCCCCHHH	35.60	23806337
1045	Phosphorylation	SISTKQISKSNPAPK CCCHHHHCCCCCCCC	27.77	26745281
1047	Phosphorylation	STKQISKSNPAPKPA CHHHHCCCCCCCCCC	41.05	26745281
1069	Phosphorylation	PNTLVAQSSHSTSNN CCCEEEECCCCCCCC	21.93	22802335
1070	Phosphorylation	NTLVAQSSHSTSNNP CCEEEECCCCCCCCC	14.91	22802335
1072	Phosphorylation	LVAQSSHSTSNNPVH EEEECCCCCCCCCCC	35.16	22802335
1073	Phosphorylation	VAQSSHSTSNNPVHK EEECCCCCCCCCCCC	30.01	22802335
1074	Phosphorylation	AQSSHSTSNNPVHKQ EECCCCCCCCCCCCC	37.31	22802335
1083	Phosphorylation	NPVHKQPSGMNISRQ CCCCCCCCCCCCCCC	48.45	22802335
1088	Phosphorylation	QPSGMNISRQSPTLN CCCCCCCCCCCCCCC	21.18	22802335
1091	Phosphorylation	GMNISRQSPTLNLLP CCCCCCCCCCCCCCC	20.81	20469934
1093	Phosphorylation	NISRQSPTLNLLPSN CCCCCCCCCCCCCCC	33.26	29472430
1116	Acetylation	KTLQAPSKLTNSSST CCCCCCCCCCCCCCC	59.27	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBN2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBN2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBN2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of UBN2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-570, AND MASSSPECTROMETRY.
PubMed: 19367708