UBN1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBN1_MOUSE
• UniProt AC: Q4G0F8
• Protein Name: Ubinuclein-1
• Gene Name: Ubn1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1135
• Subcellular Localization: Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction . Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with CLDN1.
• Protein Description: Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly (By similarity)..
• Protein Sequence: MSEPHRVQFTSVPGSLNPAFLKKSRKEEVGGTEQHQDCEPAAAAVRITLTLFEPDHKRCPEFFYPELVKNIRGKVKGLHPGDKKKDVLDPFNDEEKERHKVEALARKFEEKYGGKKRRKDRIQDLIDMGYGYDESDSFIDNSEAYDELVPASLTTKYGGFYINSGTLQFRQASESEDDFIKEKKKKSPKKRKLKEGGEKIKKKKKDDTYDKEKKSKKSKFSKAGFTALNASKEKKKKKYSGSLSVREMLKKFQKEKEAQKKREEEHKPVAVSSIEAQGLRELEGTSDPLLSLFGSTSDNDLLQAATAMDSLTDLDLEQLLSESPEGSPFRDMDDGSDSLGVGLDQEFRQPSSFPEGLPIPLEKRVKELAQAARAAEGESKQKFFTQDINGILLDIEVQTRELTSQIRSGVFAYLASFLPCSKDALVKRARKLHLYEQGGRLKEPLQKLKDAIGRAMPEQVAKYQDECQAHTQAKVAKMLEEEKDKEQRERICSDEEEDEEKGGRRIMGPRKKFQWNDEIRELLCQVVKIKLESRDLERNSKAQAWEDCVKAFLDAEVKPLWPKGWMQARTLFKESRRGHGHLTSLLAKKKVIAPSKIKMKESSVKLDKKVSVPSGQHGGPTTLLSEHQGGGLNTGANSREHPSQATCGLTDSVSVTLEDSLDEDLVRNPASSVDAVSKELATLNSRAANSSEFTLPTPSKAPTEKVGGVLCTEEKRNFAKPSSSAPPPTNALQSPLNFLAEQALALGQSSQEKKPEGSGFKELSCQGPLSKGVPELHPSKAKHHNLPRTSHGPQAAAPVPGPQVKVFHAGTQQQKSFTPPSPFVNKLQGPKATSPQCHRSLLQLVKTAAKGQAFHATMPASSGSSPASSSSAHKTTASNSTTISHPAKLHPTSSVGPSYKNNPFAGSVSKHGASSSSPSPGGGAQVQSSVSGASLPGVQSPSAGQSASRAAPSSAVKKTPVTQKLTLVAPPGGPNGDSGGGTQGVAKLLTSSLKPAAVSSVTSSTSLPKGTGGAVLLSNTSSLSLLSSSYKSNNPKLPGAMNSNSLGIITQFPLHVLSFNADSSAKAGVSKDAIVTGPAPGTFHHGLSHSLLAGLHSSPPHTAPLPHAAVSTHVPQSLPDASQLHGKGPVVPRKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
83	Acetylation	KGLHPGDKKKDVLDP CCCCCCCCCCCCCCC	68.58	7623985
85	Acetylation	LHPGDKKKDVLDPFN CCCCCCCCCCCCCCC	59.83	7623995
96	Acetylation	DPFNDEEKERHKVEA CCCCHHHHHHHHHHH	58.98	7624005
157	Phosphorylation	PASLTTKYGGFYINS CCCCEEEECCEEECC	22.01	26745281
161	Phosphorylation	TTKYGGFYINSGTLQ EEEECCEEECCCEEE	11.50	26745281
164	Phosphorylation	YGGFYINSGTLQFRQ ECCEEECCCEEEEEE	24.48	26745281
166	Phosphorylation	GFYINSGTLQFRQAS CEEECCCEEEEEECC	19.73	26745281
173	Phosphorylation	TLQFRQASESEDDFI EEEEEECCCCCCHHH	33.06	25521595
175	Phosphorylation	QFRQASESEDDFIKE EEEECCCCCCHHHHH	43.78	23684622
203	Acetylation	GGEKIKKKKKDDTYD HHHHHHHHCCCCCCC	61.11	7622543
204	Acetylation	GEKIKKKKKDDTYDK HHHHHHHCCCCCCCH	71.02	7622553
205	Acetylation	EKIKKKKKDDTYDKE HHHHHHCCCCCCCHH	70.49	7622563
222	Acetylation	SKKSKFSKAGFTALN CHHHHHHHHHHHHHH	56.51	-
231	Phosphorylation	GFTALNASKEKKKKK HHHHHHCCHHHHCCC	40.03	28066266
242	Phosphorylation	KKKKYSGSLSVREML HCCCCCCCCHHHHHH	16.13	-
323	Phosphorylation	LEQLLSESPEGSPFR HHHHHCCCCCCCCCC	25.52	-
336	Phosphorylation	FRDMDDGSDSLGVGL CCCCCCCCCCCCCCC	30.90	22817900
338	Phosphorylation	DMDDGSDSLGVGLDQ CCCCCCCCCCCCCCH	28.81	22817900
493	Phosphorylation	EQRERICSDEEEDEE HHHHHHCCCHHHHHH	45.76	25521595
595	Phosphorylation	KKKVIAPSKIKMKES HCCCCCCCCCCCCCC	37.68	28059163
603	Phosphorylation	KIKMKESSVKLDKKV CCCCCCCCCCCCCEE	25.10	29109428
660	Phosphorylation	VSVTLEDSLDEDLVR EEEEECCCCCHHHHH	28.48	-
672	Phosphorylation	LVRNPASSVDAVSKE HHHCCCHHHHHHHHH	26.56	27841257
677	Phosphorylation	ASSVDAVSKELATLN CHHHHHHHHHHHHHH	23.33	-
685	Phosphorylation	KELATLNSRAANSSE HHHHHHHHHHCCCCC	26.80	27600695
690	Phosphorylation	LNSRAANSSEFTLPT HHHHHCCCCCCCCCC	26.90	28833060
691	Phosphorylation	NSRAANSSEFTLPTP HHHHCCCCCCCCCCC	36.21	28833060
700	Acetylation	FTLPTPSKAPTEKVG CCCCCCCCCCCCCCC	60.64	7625275
705	Acetylation	PSKAPTEKVGGVLCT CCCCCCCCCCCEECC	48.97	7625285
734	Phosphorylation	PPTNALQSPLNFLAE CCCCCCCCHHHHHHH	32.00	30352176
764	Phosphorylation	GSGFKELSCQGPLSK CCCCCEEECCCCCCC	12.89	25266776
892	Phosphorylation	HPAKLHPTSSVGPSY CCCCCCCCCCCCCCC	23.92	29176673
893	Phosphorylation	PAKLHPTSSVGPSYK CCCCCCCCCCCCCCC	27.72	29176673
894	Phosphorylation	AKLHPTSSVGPSYKN CCCCCCCCCCCCCCC	33.30	25521595
898	Phosphorylation	PTSSVGPSYKNNPFA CCCCCCCCCCCCCCC	42.69	29176673
914	Phosphorylation	SVSKHGASSSSPSPG CCCCCCCCCCCCCCC	35.03	-
978	Phosphorylation	PGGPNGDSGGGTQGV CCCCCCCCCCCHHHH	40.51	28285833
1028	Phosphorylation	SSLSLLSSSYKSNNP CHHHHHCCHHHCCCC	37.34	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBN1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBN1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBN1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of UBN1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.