UBE2N_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBE2N_RAT
• UniProt AC: Q9EQX9
• Protein Name: Ubiquitin-conjugating enzyme E2 N
• Gene Name: Ube2n
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 152
• Protein Description: The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes..
• Protein Sequence: MAGLPRRIIKETQRLLAEPVPGIKAEPDESNARYFHVVIAGPQDSPFEGGTFKLELFLPEEYPMAAPKVRFMTKIYHPNVDKLGRICLDILKDKWSPALQIRTVLLSIQALLSAPNPDDPLANDVAEQWKSNEAQAIETARAWTRLYAMNNI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Acetylation	GLPRRIIKETQRLLA CCCHHHHHHHHHHHC	52.95	22902405
24	Acetylation	AEPVPGIKAEPDESN CCCCCCCCCCCCCCC	53.24	22902405
24	Ubiquitination	AEPVPGIKAEPDESN CCCCCCCCCCCCCCC	53.24	-
74	Acetylation	PKVRFMTKIYHPNVD CCEEEEECCCCCCHH	29.49	22902405
74	Ubiquitination	PKVRFMTKIYHPNVD CCEEEEECCCCCCHH	29.49	-
82	Acetylation	IYHPNVDKLGRICLD CCCCCHHHHHHHHHH	48.86	22902405
82	Ubiquitination	IYHPNVDKLGRICLD CCCCCHHHHHHHHHH	48.86	-
92	Ubiquitination	RICLDILKDKWSPAL HHHHHHHCCCCCHHH	58.56	-
92	Acetylation	RICLDILKDKWSPAL HHHHHHHCCCCCHHH	58.56	26302492
94	Acetylation	CLDILKDKWSPALQI HHHHHCCCCCHHHHH	48.24	22902405
94	Ubiquitination	CLDILKDKWSPALQI HHHHHCCCCCHHHHH	48.24	-
131	Phosphorylation	DVAEQWKSNEAQAIE HHHHHHHCCHHHHHH	36.62	23298284

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBE2N_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBE2N_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBE2N_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of UBE2N_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.