UBE2H_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBE2H_MOUSE
• UniProt AC: P62257
• Protein Name: Ubiquitin-conjugating enzyme E2 H
• Gene Name: Ube2h
• Organism: Mus musculus (Mouse).
• Sequence Length: 183
• Protein Description: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A..
• Protein Sequence: MSSPSPGKRRMDTDVVKLIESKHEVTILGGLNEFVVKFYGPQGTPYEGGVWKVRVDLPDKYPFKSPSIGFMNKIFHPNIDEASGTVCLDVINQTWTALYDLTNIFESFLPQLLAYPNPIDPLNGDAAAMYLHRPEEYKQKIKEYIQKYATEEALKEQEEGTGDSSSESSMSDFSEDEAQDMEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSPSPGKR ------CCCCCCCCC	51.46	25367039
3	Phosphorylation	-----MSSPSPGKRR -----CCCCCCCCCC	28.26	27717184
5	Phosphorylation	---MSSPSPGKRRMD ---CCCCCCCCCCCC	48.51	23375375
17	Acetylation	RMDTDVVKLIESKHE CCCCHHHHHHHCCCE	43.53	23806337
17	Succinylation	RMDTDVVKLIESKHE CCCCHHHHHHHCCCE	43.53	23806337
52	Ubiquitination	PYEGGVWKVRVDLPD CCCCCEEEEEEECCC	20.11	22790023
60	Acetylation	VRVDLPDKYPFKSPS EEEECCCCCCCCCCC	53.54	23806337
60	Ubiquitination	VRVDLPDKYPFKSPS EEEECCCCCCCCCCC	53.54	22790023
64	Acetylation	LPDKYPFKSPSIGFM CCCCCCCCCCCCCCC	57.88	23236377
64	Ubiquitination	LPDKYPFKSPSIGFM CCCCCCCCCCCCCCC	57.88	22790023
147	Acetylation	KIKEYIQKYATEEAL HHHHHHHHHHHHHHH	27.56	66697343

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBE2H_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBE2H_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBE2H_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRI72_MOUSE	Trim72	physical	23965929

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.