UBE2C_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBE2C_MOUSE
• UniProt AC: Q9D1C1
• Protein Name: Ubiquitin-conjugating enzyme E2 C
• Gene Name: Ube2c
• Organism: Mus musculus (Mouse).
• Sequence Length: 179
• Protein Description: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit..
• Protein Sequence: MASQNRDPAAASVAAVRKGAEPCGGAARGPVGKRLQQELMILMTSGDKGISAFPESDNLFKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKDKWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVSSQDP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASQNRDPA ------CCCCCCCHH	21.59	-
3	Phosphorylation	-----MASQNRDPAA -----CCCCCCCHHH	27.04	26643407
12	Phosphorylation	NRDPAAASVAAVRKG CCCHHHHHHHHHHCC	13.94	29514104
18	Ubiquitination	ASVAAVRKGAEPCGG HHHHHHHCCCCCCCC	56.74	-
23	Glutathionylation	VRKGAEPCGGAARGP HHCCCCCCCCCCCCH	6.21	24333276
119	Ubiquitination	NICLDILKDKWSALY CCHHHHHHHHHHHHH	58.56	-
119	Acetylation	NICLDILKDKWSALY CCHHHHHHHHHHHHH	58.56	23806337
121	Ubiquitination	CLDILKDKWSALYDV HHHHHHHHHHHHHHH	41.27	-
121	Acetylation	CLDILKDKWSALYDV HHHHHHHHHHHHHHH	41.27	22826441
137	Phosphorylation	TILLSIQSLLGEPNI HHHHHHHHHHCCCCC	24.72	26745281
146	Phosphorylation	LGEPNIDSPLNTHAA HCCCCCCCCCHHHHH	27.73	26745281
150	Phosphorylation	NIDSPLNTHAAELWK CCCCCCHHHHHHHHC	22.15	26745281
172	Ubiquitination	YLQETYSKQVSSQDP HHHHHHHHHCCCCCC	44.28	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBE2C_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBE2C_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBE2C_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBE2C_HUMAN	UBE2C	physical	20360068

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.