UBE11_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBE11_ARATH
• UniProt AC: P93028
• Protein Name: Ubiquitin-activating enzyme E1 1
• Gene Name: UBA1
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1080
• Protein Description: Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP..
• Protein Sequence: MLHKRASEANDKNDNTIIGSDLASSKKRRIDFTESSSDKSSSILASGSSRGFHGDSVVQQIDMAFGNSNRQEIDEDLHSRQLAVYGRETMRRLFASNVLISGMHGLGAEIAKNLILAGVKSVTLHDERVVELWDLSSNFVFSEDDVGKNRADASVQKLQDLNNAVVVSSLTKSLNKEDLSGFQVVVFSDISMERAIEFDDYCHSHQPPIAFVKADVRGLFGSVFCDFGPEFAVLDVDGEEPHTGIIASISNENQAFISCVDDERLEFEDGDLVVFSEVEGMTELNDGKPRKIKSTRPYSFTLDEDTTNYGTYVKGGIVTQVKQPKLLNFKPLREALKDPGDFLFSDFSKFDRPPLLHLAFQALDHFKAEAGRFPVAGSEEDAQKLISIATAINTGQGDLKVENVDQKLLRHFSFGAKAVLNPMAAMFGGIVGQEVVKACSGKFHPLFQFFYFDSVESLPSEPVDSSDFAPRNSRYDAQISVFGAKFQKKLEDAKVFTVGSGALGCEFLKNLALMGVSCGSQGKLTVTDDDIIEKSNLSRQFLFRDWNIGQAKSTVAASAAAVINPRFNIEALQNRVGAETENVFDDAFWENLTVVVNALDNVNARLYVDSRCLYFQKPLLESGTLGTKCNTQSVIPHLTENYGASRDPPEKQAPMCTVHSFPHNIDHCLTWARSEFEGLLEKTPAEVNAYLSSPVEYTNSMMSAGDAQARDTLERIVECLEKEKCETFQDCLTWARLRFEDYFVNRVKQLIYTFPEDAATSTGAPFWSAPKRFPRPLQYSSSDPSLLNFITATAILRAETFGIPIPEWTKNPKEAAEAVDRVIVPDFEPRQDAKIVTDEKATTLTTASVDDAAVIDDLIAKIDQCRHNLSPDFRMKPIQFEKDDDTNYHMDVIAGLANMRARNYSIPEVDKLKAKFIAGRIIPAIATSTAMATGLVCLELYKVLDGGHKVEAYRNTFANLALPLFSMAEPLPPKVVKHRDMAWTVWDRWVLKGNPTLREVLQWLEDKGLSAYSISCGSCLLFNSMFTRHKERMDKKVVDLARDVAKVELPPYRNHLDVVVACEDEDDNDVDIPLVSIYFR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	KKRRIDFTESSSDKS CCCCCCCCCCCCCCC	31.07	19880383
40	Phosphorylation	TESSSDKSSSILASG CCCCCCCCCCEEECC	34.02	25561503
41	Phosphorylation	ESSSDKSSSILASGS CCCCCCCCCEEECCC	27.43	25561503
42	Phosphorylation	SSSDKSSSILASGSS CCCCCCCCEEECCCC	28.81	25561503
46	Phosphorylation	KSSSILASGSSRGFH CCCCEEECCCCCCCC	35.44	30407730
48	Phosphorylation	SSILASGSSRGFHGD CCEEECCCCCCCCCC	17.86	25561503
49	Phosphorylation	SILASGSSRGFHGDS CEEECCCCCCCCCCH	39.69	25561503
520	Phosphorylation	LMGVSCGSQGKLTVT HCCCCCCCCCCEEEC	39.84	19880383
846	Phosphorylation	EKATTLTTASVDDAA CCCCCCEECCCCHHH	21.76	23776212
848	Phosphorylation	ATTLTTASVDDAAVI CCCCEECCCCHHHHH	24.80	30291188

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBE11_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBE11_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBE11_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of UBE11_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.