| UniProt ID | UBAP1_MOUSE | |
|---|---|---|
| UniProt AC | Q8BH48 | |
| Protein Name | Ubiquitin-associated protein 1 | |
| Gene Name | Ubap1 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 502 | |
| Subcellular Localization | Cytoplasm, cytosol. Endosome. Predominantly cytosolic. Recruited to endosomes as part of the ESCRT-I complex (By similarity).. | |
| Protein Description | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2 (By similarity).. | |
| Protein Sequence | MASKKLGTDVHGTFSYLDDVPFKIGDKFKTPAKVGLPIGFSLPDCLQVVREMQYDFSLEKKTIEWAEDIKLIQEAQREAERKAEEAEAKVNSKSGPEGDSKVSFPKTHNTATMPPPINPILASLQHNNILTPTRVSSSATKQKVLSPPHTKADFNPADFECEEDPFDNLELKTIDEKEELRNILVGTTGPIMAQLLDSNTARGSSGAVLQDEEVLASLEQATLDFKPLHKPNGFITLPQLGNCEKMSLSSKVSLPPIPTVSNIKSLSFPKLDSDDSNQKTVKLASTFHSTSCLRSGASRSLLKPSTQSSASELNGDHTLGLSALNLNSGTEVPTLTSSQMPSLSSVSVCTEESSPPDPCPTVTPLNFSVSQVPNMPSCPQAYLELQALSPSERQCVETVVNMGYSYDCVLRAMRKKGENIEQILDYLFAHGQLCEKGFDPLLVEEALEMHQCSEEKMMEFLQLMSKFKEMGFELKDIKEVLLLHNNDQDNALEDLMARAGAS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 146 | Phosphorylation | ATKQKVLSPPHTKAD CCCCCCCCCCCCCCC | 39.10 | 25521595 | |
| 150 | Phosphorylation | KVLSPPHTKADFNPA CCCCCCCCCCCCCHH | 33.43 | 28833060 | |
| 205 | Phosphorylation | SNTARGSSGAVLQDE CCCCCCCCCCCCCCH | 33.33 | - | |
| 247 | Phosphorylation | LGNCEKMSLSSKVSL CCCCEECCCCCCCCC | 35.85 | 23984901 | |
| 249 | Phosphorylation | NCEKMSLSSKVSLPP CCEECCCCCCCCCCC | 22.32 | 23984901 | |
| 250 | Phosphorylation | CEKMSLSSKVSLPPI CEECCCCCCCCCCCC | 42.23 | 23984901 | |
| 251 | Ubiquitination | EKMSLSSKVSLPPIP EECCCCCCCCCCCCC | 32.25 | - | |
| 253 | Phosphorylation | MSLSSKVSLPPIPTV CCCCCCCCCCCCCCC | 38.61 | 26745281 | |
| 259 | Phosphorylation | VSLPPIPTVSNIKSL CCCCCCCCCCCCCCC | 36.97 | - | |
| 261 | Phosphorylation | LPPIPTVSNIKSLSF CCCCCCCCCCCCCCC | 35.00 | 21454597 | |
| 265 | Phosphorylation | PTVSNIKSLSFPKLD CCCCCCCCCCCCCCC | 26.00 | 23984901 | |
| 267 | Phosphorylation | VSNIKSLSFPKLDSD CCCCCCCCCCCCCCC | 46.74 | 27742792 | |
| 285 | Phosphorylation | QKTVKLASTFHSTSC CCEEHHHHHHHHHHH | 41.88 | 23984901 | |
| 286 | Phosphorylation | KTVKLASTFHSTSCL CEEHHHHHHHHHHHH | 21.54 | 23984901 | |
| 289 | Phosphorylation | KLASTFHSTSCLRSG HHHHHHHHHHHHHCC | 20.16 | 30352176 | |
| 290 | Phosphorylation | LASTFHSTSCLRSGA HHHHHHHHHHHHCCC | 18.19 | 29472430 | |
| 291 | Phosphorylation | ASTFHSTSCLRSGAS HHHHHHHHHHHCCCC | 17.73 | 29472430 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of UBAP1_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UBAP1_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UBAP1_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of UBAP1_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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