UBA3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBA3_RAT
• UniProt AC: Q99MI7
• Protein Name: NEDD8-activating enzyme E1 catalytic subunit
• Gene Name: Uba3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 462
• Protein Description: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression..
• Protein Sequence: MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDVGRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIASMPRLPEHCIEYVRMLQWPKEQPFGDGVPLDGDDPEHIQWIFQKSVERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAERKENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTSIEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADGEEPEK ------CCCCCCHHH	33.25	-
147	Ubiquitination	NVVPHFNKIQDFNDT EECCCCCCCCCCCHH	40.58	-
307	Ubiquitination	RLTQGVVKRIIPAVA EECHHHHHHHHHHHH	35.16	-
377	Phosphorylation	LPQNIQFSPSAKLQE CCCCCCCCCCHHHHH	11.11	27097102
379	Phosphorylation	QNIQFSPSAKLQEVL CCCCCCCCHHHHHHH	36.52	27097102
398	Ubiquitination	NSASLQMKSPAITAT CCCCCCCCCCCEEEE	40.08	-
409	Acetylation	ITATLEGKNRTLYLQ EEEEEECCCCEEEEE	33.60	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBA3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBA3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBA3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ESR1_RAT	Esr1	physical	11818503

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.