UBA1_BOVIN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBA1_BOVIN
• UniProt AC: A3KMV5
• Protein Name: Ubiquitin-like modifier-activating enzyme 1
• Gene Name: UBA1
• Organism: Bos taurus (Bovine).
• Sequence Length: 1058
• Subcellular Localization: Cytoplasm . Mitochondrion . Nucleus .
• Protein Description: Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites..
• Protein Sequence: MSSSPLSKKRRVSGPDPKPGSNCSPAHSVLSEVPSVPANGMAKNVSDADIDEGLYSRQLYVLGHEAMKRLQTSSVLVSGLRGLGVEIAKNIILGGVKAVTLHDQGTAQWADLSSQFYLREEDIGKNRAEVSQPRLAELNSYVPVSAYTGPLVEDFLSDFQVVVLTNSPLEDQLRVGEFCHSHGIKLVVADTRGLFGQLFCDFGEEMILTDSNGEQPLSAMVSMVTKDNPGVVTCLDEARHGFESGDFVSFSEVQGMIELNGSQPMEIKVLGPYTFSICDTSNFSDYIRGGIVSQVKVPKKISFKSLPASLAEPDFVMTDFAKYSRPAQLHIGFQALHHFCAQHGRSPRPHNEEDAAELVTIAQAVNARSLPAVQQGSLDEDLIRKLAYVAAGDLAPINAFIGGLAAQEVMKACSGKFMPIMQWLYFDALECLPEDKEALTEDKCLPRQNRYDGQVAVFGSDLQERLGKQKYFLVGAGAIGCELLKNFAMIGLGCAEDGEIVVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPHIRVTSHQNRVGPDTERIYDDDFFQNLDGVTNALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPAENVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPQTWADCVTWACHHWHTQYSNNIRQLLHNFPPDQLTSSGAPFWSGPKRCPHPLTFDVSNPLHLDYVIAAANLFAQTYGLTGSQDRAAVATLLQSVQVPEFTPKSGVKIHVSDQELQSANASVDDSRLEELKATLPSPEKLPGFKMYPIDFEKDDDTNFHMDFIVAASNLRAENYDIPPADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHRQLNSYKNGFLNLALPFFGFSEPLAAPRHQYYNQEWTLWDRFEVQGLQPNGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVSRVSKRKLGRHVRALVLELCCNDESGEDVEVPYVRYTIR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSSSPLSKK ------CCCCCCCCC	51.32	-
4	Phosphorylation	----MSSSPLSKKRR ----CCCCCCCCCCC	38.87	-
13	Phosphorylation	LSKKRRVSGPDPKPG CCCCCCCCCCCCCCC	42.68	-
21	Phosphorylation	GPDPKPGSNCSPAHS CCCCCCCCCCCCCHH	43.10	-
24	Phosphorylation	PKPGSNCSPAHSVLS CCCCCCCCCCHHHHC	29.40	-
46	Phosphorylation	NGMAKNVSDADIDEG CCCCCCCCCCCCCCC	36.15	-
55	Phosphorylation	ADIDEGLYSRQLYVL CCCCCCHHHHHHHHH	16.80	-
528	Succinylation	PWDVTKLKSDTAAAA CCCHHHCCHHHHHHH	48.09	-
528	Succinylation	PWDVTKLKSDTAAAA CCCHHHCCHHHHHHH	48.09	-
671	Acetylation	NQYLTDPKFVERTLR HHHHCCHHHHHHHHH	65.92	-
800	Phosphorylation	SVQVPEFTPKSGVKI HCCCCCCCCCCCCEE	28.30	-
810	Phosphorylation	SGVKIHVSDQELQSA CCCEEEECHHHHHHC	21.29	-
816	Phosphorylation	VSDQELQSANASVDD ECHHHHHHCCCCCCH	35.79	-
820	Phosphorylation	ELQSANASVDDSRLE HHHHCCCCCCHHHHH	26.36	-
835	Phosphorylation	ELKATLPSPEKLPGF HHHHHCCCCCCCCCC	49.13	-
980	Acetylation	KQFLDYFKTEHKLEI HHHHHHHHHCCHHHH	46.93	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBA1_BOVIN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBA1_BOVIN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBA1_BOVIN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.