UB2D2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UB2D2_MOUSE
• UniProt AC: P62838
• Protein Name: Ubiquitin-conjugating enzyme E2 D2
• Gene Name: Ube2d2
• Organism: Mus musculus (Mouse).
• Sequence Length: 147
• Protein Description: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3..
• Protein Sequence: MALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLVPEIARIYKTDREKYNRIAREWTQKYAM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Ubiquitination	MALKRIHKELNDLAR CCHHHHHHHHHHHHH	62.62	-
8	Malonylation	MALKRIHKELNDLAR CCHHHHHHHHHHHHH	62.62	26320211
80	Phosphorylation	IYHPNINSNGSICLD EECCCCCCCCEEHHH	38.48	23984901
83	Phosphorylation	PNINSNGSICLDILR CCCCCCCEEHHHHHH	17.87	26745281
85	S-nitrosocysteine	INSNGSICLDILRSQ CCCCCEEHHHHHHHC	2.75	-
85	S-nitrosylation	INSNGSICLDILRSQ CCCCCEEHHHHHHHC	2.75	20925432
91	Phosphorylation	ICLDILRSQWSPALT EHHHHHHHCCCCCHH	32.34	22817900
111	S-nitrosocysteine	LSICSLLCDPNPDDP HHHHHHHCCCCCCCC	11.23	-
111	S-nitrosylation	LSICSLLCDPNPDDP HHHHHHHCCCCCCCC	11.23	20925432
128	Ubiquitination	PEIARIYKTDREKYN HHHHHHHHHCHHHHH	41.39	-
144	Ubiquitination	IAREWTQKYAM---- HHHHHHHHHCC----	27.83	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UB2D2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UB2D2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UB2D2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RNF25_MOUSE	Rnf25	physical	10500182

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.