| UniProt ID | U17L5_HUMAN | |
|---|---|---|
| UniProt AC | A8MUK1 | |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 17-like protein 5 | |
| Gene Name | USP17L5 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 530 | |
| Subcellular Localization | Nucleus. Endoplasmic reticulum. | |
| Protein Description | Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.. | |
| Protein Sequence | MEDDSLYLRGEWQFNHFSKLTSSRPDAAFAEIQRTSLPEKSPLSCETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSREHSQTCHRHKGCMLCTMQAHITRALHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKKACLPGHKQVDHHSKDTTLIHQIFGGYWRSQIKCLHCHGISDTFDPYLDIALDIQAAQSVQQALEQLAKPEELNGENAYHCGVCLQRAPASKTLTLHTSAKVLILVLKRFSDVTGNKIAKNVQYPECLDMQPYMSQPNTGPLVYVLYAVLVHAGWSCHNGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFYIQKSEWERHSESVSRGREPRALGAEDTDRRATQGELKRDHPCLQAPELDEHLVERATQESTLDHWKFLQEQNKTKPEFNVRKVEGTLPPDVLVIHQSKYKCGMKNHHPEQQSSLLNLSSSTPTHQESMNTGTLASLRGRARRSKGKNKHSKRALLVCQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 5 | Phosphorylation | ---MEDDSLYLRGEW ---CCCCCEEECCEE | 31.10 | 29083192 | |
| 7 | Phosphorylation | -MEDDSLYLRGEWQF -CCCCCEEECCEEEC | 9.78 | 29083192 | |
| 114 | Phosphorylation | YMLSREHSQTCHRHK HHHCCCHHCCCHHCC | 23.56 | 28787133 | |
| 272 | Phosphorylation | KTLTLHTSAKVLILV CEEEEECHHHHHHHH | 18.49 | - | |
| 284 | Phosphorylation | ILVLKRFSDVTGNKI HHHHHHHCCCCCCHH | 34.89 | - | |
| 287 | Phosphorylation | LKRFSDVTGNKIAKN HHHHCCCCCCHHHCC | 39.77 | - | |
| 355 | Phosphorylation | KMDDAEVTASSITSV ECCCCEEEHHHHHHH | 16.60 | 22210691 | |
| 357 | Phosphorylation | DDAEVTASSITSVLS CCCEEEHHHHHHHHH | 16.95 | 22210691 | |
| 368 | Phosphorylation | SVLSQQAYVLFYIQK HHHHCCEEEEEEEEH | 8.05 | 22210691 | |
| 376 | Phosphorylation | VLFYIQKSEWERHSE EEEEEEHHHHHHHHH | 31.41 | 22210691 | |
| 399 | Phosphorylation | RALGAEDTDRRATQG CCCCCCCCCCHHHHC | 23.94 | - | |
| 445 | Ubiquitination | KFLQEQNKTKPEFNV HHHHHHHCCCCCCCE | 58.58 | 16196087 | |
| 493 | Phosphorylation | LLNLSSSTPTHQESM HHHCCCCCCCCHHHC | 33.87 | 28787133 | |
| 507 | Phosphorylation | MNTGTLASLRGRARR CCCCHHHHHHHHHHH | 23.01 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of U17L5_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of U17L5_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of U17L5_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of U17L5_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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