TYW1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TYW1_SCHPO
• UniProt AC: O59761
• Protein Name: S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
• Gene Name: tyw1
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 688
• Protein Description: Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity)..
• Protein Sequence: MGYSLGYIGEHWEEYRAVLYIVLLLPVLIHFLIRRKTQLSNSDKSSEKKDEVKKQREVKRFKRVGKRGKIGSPSSSIRKQNDTIDWKNSPLCVFYSTLGGTAERYAKQVHEELSSLLQRDDIQLLNLDYVDLSEYFVSCPENAIYLVVLPSYEIESSIDYYLSSLQESFSDFRVPKDPLHGLSGYAVFGLGDMENYPGDKFCYQAIQADKWIKKLGARRLAPLGVVNTQLAPTAQIDALLQWTRSVAECLKNGTLLKIGNTDSLSSDVMDVEDMGSMMAKAKAEAALPVGTKEMVSTESPTYKALTKQGYSVVGSHSGVKICRWTKSAMRGRGFCYKYSFYGIRSHLCMEATPSLACANKCTFCWRHGTNPVGTSWRWKVDPPEMILQGILKAHYAKLKLMKGVPGVLPDRYEEASRVRHCALSLVGEPIFYPYINEFVSMLHEREISSFLVTNAQHPEALRNMGMVTQLYVSVDASTKQSLKSVDRPLFKDFWERMLTCLEILREKRQRTVYRMTLVKGFNMEQIKEYTELIRLGVPCFIEVKGVTYSGNSDQSPLTMKNVPYYEEVIDFVKKLIEYIDIHLQDLGVRYEIAAEHAHSCSILVAQTAFKKDGHWHTHIDYPKFFELIRTKKDFGPFDYMASTPDFAMFGNGGFSPEDTRFHRKKKTQTSKPISATISETATISEAAA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
72	Phosphorylation	GKRGKIGSPSSSIRK CCCCCCCCCCHHHHC	25.69	28889911
74	Phosphorylation	RGKIGSPSSSIRKQN CCCCCCCCHHHHCCC	38.11	24763107
75	Phosphorylation	GKIGSPSSSIRKQND CCCCCCCHHHHCCCC	32.92	21712547
76	Phosphorylation	KIGSPSSSIRKQNDT CCCCCCHHHHCCCCC	30.65	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TYW1_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TYW1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TYW1_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of TYW1_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.