dbPTM

TXNL1_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TXNL1_RAT
UniProt AC	Q920J4
Protein Name	Thioredoxin-like protein 1
Gene Name	Txnl1
Organism	Rattus norvegicus (Rat).
Sequence Length	289
Subcellular Localization	Cytoplasm. Nucleus. At least 85% of the cellular TXNL1 is proteasome-associated..
Protein Description	Active thioredoxin with a redox potential of about -250 mV..
Protein Sequence	MVGVKPVGSDPDFQPELSGAGSRLAVVKFTMRGCGPCLRIAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFRNKVRIDQYQGADAVGLEEKIKQHLENDPGSNEDTDIPKGYMDLMPFINKAGCECLNESDEHGFDNCLRKDLSFLESDCDEQLLITVAFNQPVKLYSMKFQGPDNGQGPKYVKIFINLPRSMDFEEAERSEPTQALELTEDDIKEDGIVPLRYVKFQNVNSVTLFVQSNQGEEETTRISYFTFIGTPVQATNMNDFKRVVGKKGESH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	VGVKPVGSDPDFQPE CCCCCCCCCCCCCHH	46.32	22673903
18	Phosphorylation	PDFQPELSGAGSRLA CCCCHHHCCCCCCEE	25.57	25575281
22	Phosphorylation	PELSGAGSRLAVVKF HHHCCCCCCEEEEEE	24.48	25575281
102	Ubiquitination	DAVGLEEKIKQHLEN CCCCHHHHHHHHHHC	45.92	-
113	Phosphorylation	HLENDPGSNEDTDIP HHHCCCCCCCCCCCC	42.29	29779826
117	Phosphorylation	DPGSNEDTDIPKGYM CCCCCCCCCCCCCHH	29.65	27097102
123	Phosphorylation	DTDIPKGYMDLMPFI CCCCCCCHHHHHHHH	8.12	25575281
181	Ubiquitination	PVKLYSMKFQGPDNG CEEEEEEEEECCCCC	28.70	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TXNL1_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TXNL1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TXNL1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TXNL1_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TXNL1_RAT

Related Literatures of Post-Translational Modification