TXNIP_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TXNIP_RAT
• UniProt AC: Q5M7W1
• Protein Name: Thioredoxin-interacting protein
• Gene Name: Txnip
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 394
• Subcellular Localization: Cytoplasm.
• Protein Description: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth (By similarity)..
• Protein Sequence: MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVTVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTLDYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQEAKKNFEVMDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDDISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWIDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDVDDSQDSPIFMYAPEFQFMPPPTYTEVDPCVLNNNNNNVQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
26	Ubiquitination	KVYGSGEKVAGRVTV HCCCCCCEECCEEEE	40.69	-
113	Phosphorylation	PQGPLGTSFKGKYGC CCCCCCCCCCCCCCC	24.14	22108457
115	Ubiquitination	GPLGTSFKGKYGCVD CCCCCCCCCCCCCHH	55.02	-
117	Ubiquitination	LGTSFKGKYGCVDYW CCCCCCCCCCCHHHH	38.77	-
140	Ubiquitination	SQPTQEAKKNFEVMD CCCCHHHHHCCEEEE	47.71	-
163	Ubiquitination	LMAPVSAKKEKKVSC HHCCCCCCCCCCEEE	54.69	-
167	Ubiquitination	VSAKKEKKVSCMFIP CCCCCCCCEEEEEEC	40.24	-
187	Ubiquitination	VSARIDRKGFCEGDD EEEEECCCCCCCCCC	53.22	-
361	Phosphorylation	DVDDSQDSPIFMYAP CCCCCCCCCCEEECC	16.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TXNIP_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TXNIP_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TXNIP_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of TXNIP_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.