TXNIP_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TXNIP_MOUSE
• UniProt AC: Q8BG60
• Protein Name: Thioredoxin-interacting protein
• Gene Name: Txnip
• Organism: Mus musculus (Mouse).
• Sequence Length: 397
• Subcellular Localization: Cytoplasm .
• Protein Description: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth..
• Protein Sequence: MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTLDYLRYEDTLLLEEQPTAGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQEAKKNFEVMDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDDISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVFTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILKVEYSLLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWIDLNIPDTPEAPPCYMDIIPEDHRLESPTTPLLDDVDDSQDSPIFMYAPEFQFMPPPTYTEVDPCVLNNNNNNNNVQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	VMFKKIKSFEVVFND CCCEECCEEEEEECC	30.07	19854140
19	Ubiquitination	VVFNDPEKVYGSGEK EEECCHHHHCCCCCE	46.26	-
26	Ubiquitination	KVYGSGEKVAGRVIV HHCCCCCEECCEEEE	40.69	27667366
39	Phosphorylation	IVEVCEVTRVKAVRI EEEEEECCCCEEHHH	13.88	21659605
64	Ubiquitination	MQGSQQCKQTLDYLR HCCCHHHHHHHHHHH	41.81	-
116	Ubiquitination	GPLGTSFKGKYGCVD CCCCCCCCCCCCCHH	55.02	-
118	Ubiquitination	LGTSFKGKYGCVDYW CCCCCCCCCCCHHHH	38.77	-
141	Ubiquitination	SQPTQEAKKNFEVMD CCCCHHHHHCCEEEE	47.71	-
154	Phosphorylation	MDLVDVNTPDLMAPV EECCCCCCCCHHCCC	20.30	25338131
164	Ubiquitination	LMAPVSAKKEKKVSC HHCCCCCCCCCCEEE	54.69	-
165	Acetylation	MAPVSAKKEKKVSCM HCCCCCCCCCCEEEE	74.59	15624277
167	Acetylation	PVSAKKEKKVSCMFI CCCCCCCCCEEEEEE	68.31	15624285
168	Ubiquitination	VSAKKEKKVSCMFIP CCCCCCCCEEEEEEC	40.24	-
171	Glutathionylation	KKEKKVSCMFIPDGR CCCCCEEEEEECCCC	2.64	24333276
188	Ubiquitination	VSARIDRKGFCEGDD EEEEECCCCCCCCCC	53.22	-
212	Ubiquitination	TCSRIVVPKAAIVAR CCCCCEECHHHEEEE	15.07	27667366
213	Ubiquitination	CSRIVVPKAAIVARH CCCCEECHHHEEEEE	38.55	27667366
229	Ubiquitination	YLANGQTKVFTQKLS EECCCCEEEEEEECH	27.71	-
233	Ubiquitination	GQTKVFTQKLSSVRG CCEEEEEEECHHHCC	32.98	27667366
234	Ubiquitination	QTKVFTQKLSSVRGN CEEEEEEECHHHCCC	47.48	27667366
248	Glutathionylation	NHIISGTCASWRGKS CEEEECCCCCCCCCC	3.01	24333276
254	Acetylation	TCASWRGKSLRVQKI CCCCCCCCCCEEEEC	37.43	15630777
288	Ubiquitination	VSVPGSKKVILDLPL EECCCCCEEEEECCE	35.88	-
299	Phosphorylation	DLPLVIGSRSGLSSR ECCEEEECCCCCCHH	16.49	29514104
301	Phosphorylation	PLVIGSRSGLSSRTS CEEEECCCCCCHHCC	45.87	27600695
305	Phosphorylation	GSRSGLSSRTSSMAS ECCCCCCHHCCHHCC	44.62	25338131
307	Phosphorylation	RSGLSSRTSSMASRT CCCCCHHCCHHCCCC	27.40	25338131
308	Phosphorylation	SGLSSRTSSMASRTS CCCCHHCCHHCCCCC	19.60	25338131
309	Phosphorylation	GLSSRTSSMASRTSS CCCHHCCHHCCCCCC	20.11	-
362	Phosphorylation	DVDDSQDSPIFMYAP CCCCCCCCCCEEECC	16.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
309	S	Phosphorylation	Kinase	AKT1	P31749	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TXNIP_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TXNIP_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
THIO_HUMAN	TXN	physical	10843682

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.