TWST2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TWST2_MOUSE
• UniProt AC: Q9D030
• Protein Name: Twist-related protein 2
• Gene Name: Twist2
• Organism: Mus musculus (Mouse).
• Sequence Length: 160
• Subcellular Localization: Nucleus . Cytoplasm . Mainly nuclear during embryonic development. Cytoplasmic in adult tissues.
• Protein Description: Binds to the E-box consensus sequence 5'-CANNTG-3' as a heterodimer and inhibits transcriptional activation by MYOD1, MYOG, MEF2A and MEF2C. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Involved in postnatal glycogen storage and energy metabolism. Inhibits the premature or ectopic differentiation of preosteoblast cells during osteogenesis, possibly by changing the internal signal transduction response of osteoblasts to external growth factors (By similarity)..
• Protein Sequence: MEEGSSSPVSPVDSLGTSEEELERQPKRFGRKRRYSKKSSEDGSPTPGKRGKKGSPSAQSFEELQSQRILANVRERQRTQSLNEAFAALRKIIPTLPSDKLSKIQTLKLAARYIDFLYQVLQSDEMDNKMTSCSYVAHERLSYAYSVWRMEGAWSMSASH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MEEGSSSPVSPV ---CCCCCCCCCCCC	30.81	25338131
6	Phosphorylation	--MEEGSSSPVSPVD --CCCCCCCCCCCCC	49.90	25338131
7	Phosphorylation	-MEEGSSSPVSPVDS -CCCCCCCCCCCCCC	30.90	29514104
10	Phosphorylation	EGSSSPVSPVDSLGT CCCCCCCCCCCCCCC	23.69	29514104
14	Phosphorylation	SPVSPVDSLGTSEEE CCCCCCCCCCCCHHH	29.00	29514104
39	Phosphorylation	KRRYSKKSSEDGSPT CCCCCCCCCCCCCCC	42.57	29514104
40	Phosphorylation	RRYSKKSSEDGSPTP CCCCCCCCCCCCCCC	48.89	29514104
44	Phosphorylation	KKSSEDGSPTPGKRG CCCCCCCCCCCCCCC	37.61	23684622
46	Phosphorylation	SSEDGSPTPGKRGKK CCCCCCCCCCCCCCC	46.50	23375375
55	Phosphorylation	GKRGKKGSPSAQSFE CCCCCCCCCCHHCHH	25.26	27149854
57	Phosphorylation	RGKKGSPSAQSFEEL CCCCCCCCHHCHHHH	40.41	25619855
60	Phosphorylation	KGSPSAQSFEELQSQ CCCCCHHCHHHHHHH	34.05	25619855
79	Phosphorylation	NVRERQRTQSLNEAF HHHHHHHHHHHHHHH	17.74	-
81	Phosphorylation	RERQRTQSLNEAFAA HHHHHHHHHHHHHHH	32.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TWST2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TWST2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TWST2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TWST2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.