TULP4_HUMAN - dbPTM
TULP4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TULP4_HUMAN
UniProt AC Q9NRJ4
Protein Name Tubby-related protein 4
Gene Name TULP4
Organism Homo sapiens (Human).
Sequence Length 1543
Subcellular Localization Cytoplasm.
Protein Description May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins..
Protein Sequence MYAAVEHGPVLCSDSNILCLSWKGRVPKSEKEKPVCRRRYYEEGWLATGNGRGVVGVTFTSSHCRRDRSTPQRINFNLRGHNSEVVLVRWNEPYQKLATCDADGGIFVWIQYEGRWSVELVNDRGAQVSDFTWSHDGTQALISYRDGFVLVGSVSGQRHWSSEINLESQITCGIWTPDDQQVLFGTADGQVIVMDCHGRMLAHVLLHESDGVLGMSWNYPIFLVEDSSESDTDSDDYAPPQDGPAAYPIPVQNIKPLLTVSFTSGDISLMNNYDDLSPTVIRSGLKEVVAQWCTQGDLLAVAGMERQTQLGELPNGPLLKSAMVKFYNVRGEHIFTLDTLVQRPIISICWGHRDSRLLMASGPALYVVRVEHRVSSLQLLCQQAIASTLREDKDVSKLTLPPRLCSYLSTAFIPTIKPPIPDPNNMRDFVSYPSAGNERLHCTMKRTEDDPEVGGPCYTLYLEYLGGLVPILKGRRISKLRPEFVIMDPRTDSKPDEIYGNSLISTVIDSCNCSDSSDIELSDDWAAKKSPKISRASKSPKLPRISIEARKSPKLPRAAQELSRSPRLPLRKPSVGSPSLTRREFPFEDITQHNYLAQVTSNIWGTKFKIVGLAAFLPTNLGAVIYKTSLLHLQPRQMTIYLPEVRKISMDYINLPVFNPNVFSEDEDDLPVTGASGVPENSPPCTVNIPIAPIHSSAQAMSPTQSIGLVQSLLANQNVQLDVLTNQTTAVGTAEHAGDSATQYPVSNRYSNPGQVIFGSVEMGRIIQNPPPLSLPPPPQGPMQLSTVGHGDRDHEHLQKSAKALRPTPQLAAEGDAVVFSAPQEVQVTKINPPPPYPGTIPAAPTTAAPPPPLPPPQPPVDVCLKKGDFSLYPTSVHYQTPLGYERITTFDSSGNVEEVCRPRTRMLCSQNTYTLPGPGSSATLRLTATEKKVPQPCSSATLNRLTVPRYSIPTGDPPPYPEIASQLAQGRGAAQRSDNSLIHATLRRNNREATLKMAQLADSPRAPLQPLAKSKGGPGGVVTQLPARPPPALYTCSQCSGTGPSSQPGASLAHTASASPLASQSSYSLLSPPDSARDRTDYVNSAFTEDEALSQHCQLEKPLRHPPLPEAAVTLKRPPPYQWDPMLGEDVWVPQERTAQTSGPNPLKLSSLMLSQGQHLDVSRLPFISPKSPASPTATFQTGYGMGVPYPGSYNNPPLPGVQAPCSPKDALSPTQFAQQEPAVVLQPLYPPSLSYCTLPPMYPGSSTCSSLQLPPVALHPWSSYSACPPMQNPQGTLPPKPHLVVEKPLVSPPPADLQSHLGTEVMVETADNFQEVLSLTESPVPQRTEKFGKKNRKRLDSRAEEGSVQAITEGKVKKEARTLSDFNSLISSPHLGREKKKVKSQKDQLKSKKLNKTNEFQDSSESEPELFISGDELMNQSQGSRKGWKSKRSPRAAGELEEAKCRRASEKEDGRLGSQGFVYVMANKQPLWNEATQVYQLDFGGRVTQESAKNFQIELEGRQVMQFGRIDGSAYILDFQYPFSAVQAFAVALANVTQRLK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
366PhosphorylationMASGPALYVVRVEHR
ECCCCEEEEEEEEHH		10.06-
399PhosphorylationDKDVSKLTLPPRLCS
CCCHHHCCCCHHHHH		40.7424719451
407PhosphorylationLPPRLCSYLSTAFIP
CCHHHHHHHHHCCCC		12.0424719451
434PhosphorylationRDFVSYPSAGNERLH
CCCCCCCCCCCCEEE		40.3428509920
443PhosphorylationGNERLHCTMKRTEDD
CCCEEEEEEEECCCC		18.2528509920
537PhosphorylationSPKISRASKSPKLPR
CCCCCCCCCCCCCCC		32.3423403867
539PhosphorylationKISRASKSPKLPRIS
CCCCCCCCCCCCCEE		25.4423403867
546PhosphorylationSPKLPRISIEARKSP
CCCCCCEEEEECCCC		18.6928555341
552PhosphorylationISIEARKSPKLPRAA
EEEEECCCCCCHHHH		23.0123403867
563PhosphorylationPRAAQELSRSPRLPL
HHHHHHHHCCCCCCC		29.9327174698
565PhosphorylationAAQELSRSPRLPLRK
HHHHHHCCCCCCCCC		15.8227174698
574PhosphorylationRLPLRKPSVGSPSLT
CCCCCCCCCCCCCCC		41.9929255136
577PhosphorylationLRKPSVGSPSLTRRE
CCCCCCCCCCCCCCC		14.7929255136
579PhosphorylationKPSVGSPSLTRREFP
CCCCCCCCCCCCCCC		44.0323403867
581PhosphorylationSVGSPSLTRREFPFE
CCCCCCCCCCCCCHH		31.8323403867
626PhosphorylationTNLGAVIYKTSLLHL
CCHHHHHHECCHHCC		11.1223403867
627UbiquitinationNLGAVIYKTSLLHLQ
CHHHHHHECCHHCCC		22.10-
628PhosphorylationLGAVIYKTSLLHLQP
HHHHHHECCHHCCCC		13.9727251275
629PhosphorylationGAVIYKTSLLHLQPR
HHHHHECCHHCCCCC		25.4527251275
751PhosphorylationYPVSNRYSNPGQVIF
CCCCCCCCCCCCEEE		33.0528122231
873PhosphorylationKKGDFSLYPTSVHYQ
ECCCCEECCCEEEEC		11.85-
879PhosphorylationLYPTSVHYQTPLGYE
ECCCEEEECCCCCCE		16.3627259358
913PhosphorylationRMLCSQNTYTLPGPG
EEEECCCCEECCCCC		15.3924114839
914PhosphorylationMLCSQNTYTLPGPGS
EEECCCCEECCCCCC		17.5224114839
921PhosphorylationYTLPGPGSSATLRLT
EECCCCCCCCEEEEE		21.6724114839
945MethylationCSSATLNRLTVPRYS
CCCCCCCCCCCCCCC		34.54-
945Asymmetric dimethylarginineCSSATLNRLTVPRYS
CCCCCCCCCCCCCCC		34.54-
947PhosphorylationSATLNRLTVPRYSIP
CCCCCCCCCCCCCCC		25.8124719451
950Asymmetric dimethylarginineLNRLTVPRYSIPTGD
CCCCCCCCCCCCCCC		33.23-
950MethylationLNRLTVPRYSIPTGD
CCCCCCCCCCCCCCC		33.2354549177
952PhosphorylationRLTVPRYSIPTGDPP
CCCCCCCCCCCCCCC		24.3028348404
955PhosphorylationVPRYSIPTGDPPPYP
CCCCCCCCCCCCCCH		53.1728348404
972MethylationASQLAQGRGAAQRSD
HHHHHCCCCCCHHCC		21.35115919177
995PhosphorylationRRNNREATLKMAQLA
HHCCHHHHHHHHHHC		23.3520639409
997MethylationNNREATLKMAQLADS
CCHHHHHHHHHHCCC		28.03116253825
1004PhosphorylationKMAQLADSPRAPLQP
HHHHHCCCCCCCCHH		15.6420639409
1006MethylationAQLADSPRAPLQPLA
HHHCCCCCCCCHHHH		53.4454561905
1006DimethylationAQLADSPRAPLQPLA
HHHCCCCCCCCHHHH		53.44-
1060PhosphorylationLAHTASASPLASQSS
HHCCCCCCCCCCCCC		20.25-
1068PhosphorylationPLASQSSYSLLSPPD
CCCCCCCCCCCCCCC		14.48-
1173PhosphorylationLPFISPKSPASPTAT
CCCCCCCCCCCCCCE		29.1428348404
1176PhosphorylationISPKSPASPTATFQT
CCCCCCCCCCCEEEC		26.6028348404
1178PhosphorylationPKSPASPTATFQTGY
CCCCCCCCCEEECCC		35.5228348404
1180PhosphorylationSPASPTATFQTGYGM
CCCCCCCEEECCCCC		20.8228348404
1183PhosphorylationSPTATFQTGYGMGVP
CCCCEEECCCCCCCC		28.3428348404
1343PhosphorylationKNRKRLDSRAEEGSV
HHHHHHHHHCHHCCC		37.6725159151
1349PhosphorylationDSRAEEGSVQAITEG
HHHCHHCCCHHHHCC		17.8429978859
1354PhosphorylationEGSVQAITEGKVKKE
HCCCHHHHCCCCHHE		41.5223312004
1364PhosphorylationKVKKEARTLSDFNSL
CCHHEEEEHHHHHHH		37.3527080861
1366PhosphorylationKKEARTLSDFNSLIS
HHEEEEHHHHHHHHC		39.2728450419
1370PhosphorylationRTLSDFNSLISSPHL
EEHHHHHHHHCCCCC		27.3728450419
1373PhosphorylationSDFNSLISSPHLGRE
HHHHHHHCCCCCCCC		43.0125159151
1374PhosphorylationDFNSLISSPHLGREK
HHHHHHCCCCCCCCH		14.8925159151
1446UbiquitinationAGELEEAKCRRASEK
HHHHHHHHHHCCHHC		31.39-
1453UbiquitinationKCRRASEKEDGRLGS
HHHCCHHCCCCCCCC		59.6227667366
1476UbiquitinationNKQPLWNEATQVYQL
CCCCCCCCCCEEEEE		41.3227667366
1493O-linked_GlycosylationGGRVTQESAKNFQIE
CCCCCHHHHHCEEEE		34.4229351928
1495UbiquitinationRVTQESAKNFQIELE
CCCHHHHHCEEEEEC		68.52-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TULP4_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TULP4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TULP4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TULP4_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TULP4_HUMAN

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Related Literatures of Post-Translational Modification

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