| UniProt ID | TTYH1_HUMAN | |
|---|---|---|
| UniProt AC | Q9H313 | |
| Protein Name | Protein tweety homolog 1 | |
| Gene Name | TTYH1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 450 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein. |
|
| Protein Description | Probable chloride channel. May be involved in cell adhesion (By similarity).; Isoform 3 may be a Ca(2+)-independent and swelling-activated chloride channel, possibly involved in regulation of cell volume.. | |
| Protein Sequence | MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSVFAPQEQEYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPPGSKIPSPGGGCVTWSCIVALLAGCTGIGIGFYGNSETSDGVSQLSSALLHANHTLSTIDHLVLETVERLGEAVRTELTTLEEVLEPRTELVAAARGARRQAEAAAQQLQGLAFWQGVPLSPLQVAENVSFVEEYRWLAYVLLLLLELLVCLFTLLGLAKQSKWLVIVMTVMSLLVLVLSWGSMGLEAATAVGLSDFCSNPDPYVLNLTQEETGLSSDILSYYLLCNRAVSNPFQQRLTLSQRALANIHSQLLGLEREAVPQFPSAQKPLLSLEETLNVTEGNFHQLVALLHCRSLHKDYGAALRGLCEDALEGLLFLLLFSLLSAGALATALCSLPRAWALFPPSDDYDDTDDDDPFNPQESKRFVQWQSSI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 130 | N-linked_Glycosylation | SSALLHANHTLSTID HHHHHHHCCHHHHHH | 20.23 | UniProtKB CARBOHYD | |
| 205 | N-linked_Glycosylation | SPLQVAENVSFVEEY CHHCHHCCCCHHHHH | 25.62 | UniProtKB CARBOHYD | |
| 284 | N-linked_Glycosylation | NPDPYVLNLTQEETG CCCCCEEECCHHHHC | 30.88 | UniProtKB CARBOHYD | |
| 349 | Phosphorylation | SAQKPLLSLEETLNV CCCCCCCCHHHHHCC | 41.22 | - | |
| 355 | N-linked_Glycosylation | LSLEETLNVTEGNFH CCHHHHHCCCCCCHH | 46.19 | UniProtKB CARBOHYD | |
| 432 (in isoform 3) | Phosphorylation | - | 69.19 | 22210691 | |
| 435 (in isoform 3) | Phosphorylation | - | 30.51 | 26670566 | |
| 440 | Phosphorylation | DPFNPQESKRFVQWQ CCCCHHHHHHHHHHH | 24.71 | - | |
| 447 | Phosphorylation | SKRFVQWQSSI---- HHHHHHHHHCC---- | 15.37 | 27251275 | |
| 447 (in isoform 3) | Phosphorylation | - | 15.37 | 26670566 | |
| 448 | Phosphorylation | KRFVQWQSSI----- HHHHHHHHCC----- | 27.35 | 28348404 | |
| 449 | Phosphorylation | RFVQWQSSI------ HHHHHHHCC------ | 19.74 | 22912867 | |
| 450 | Phosphorylation | FVQWQSSI------- HHHHHHCC------- | 8.73 | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TTYH1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TTYH1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TTYH1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of TTYH1_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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