TTF2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TTF2_MOUSE
• UniProt AC: Q5NC05
• Protein Name: Transcription termination factor 2
• Gene Name: Ttf2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1138
• Subcellular Localization: Cytoplasm. Nucleus. Cytoplasmic during interphase. Relocates to the nucleus as cells enter mitosis (By similarity)..
• Protein Description: DsDNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. May contribute to mitotic transcription repression. May also be involved in pre-mRNA splicing (By similarity)..
• Protein Sequence: MDLVKCPEHGDACFLKTGVRDGPNKGKSFYVCRTNTCGFVQATDIPVSHCLLHEEFVVELQGLFLPQDKKEWRLFFRCARTKAEGKQWCGNVPWRQDPNPKELSVTSKPQQPSESQLHSPSQPRNPFRVLNKNQKTLERKQFVEEGERKTADKKLRENNEQLLDQRKEQKPKSNSRMEKDPSSDLVATRQSGGDREEQEKSKFQPKTKKAEGMASKQGHGEVLQGIPKGPHMSESESRGVPNKPETLREKETQLLVPSVPGQNPESKVQKEGHVSREPLKNGEAPSAQVTQRGLAQGPLQGPSKTWRPVPEAPAAPELCSGMAHHATSSSEDSEDDGVSSRPGSPLLFDSTVDSQKKGSLQHSDQSVQRQMPAASGVSKKGDSSDPAAQRANLTTQLKQKKGTLAAVNIQALPDKGEKLLKQIQALEDALSALALSPEQGTKEKCSAQEPEQSNITKAAAAPLHLVPPQPLPRPLIQPASSLGLKAGRQETPEGASQCSGGHMNQHHLYNVWKITSEAIDELHRSLKSCPGETAVAEDPAGLKVPLLLHQKQALAWLLWRESQKPQGGILADDMGLGKTLTMIALILTKKNQQKSKEKERSEPVTWLSKNDSSVFTSSGTLIVCPASLIHHWKNEVEKRVTSNRLRIYLYHGPNRSRHAKVLSTYDIVITTYSLLAKEIPTTKQEGEVPGANLSVEGTSAPLLQVVWARIILDEAHNVKNPRVQTSIAVCKLQAQARWAVTGTPIQNNLLDMYSLMKFLRCSPFDEFSLWKSQVDNGSMKGGERLSILTKSLLLRRTKDQLDSTGKPLVALPARRCQLHRLKLSEDERAVYDIFLARSRSALQSYLKRQEGRGSHHGRSPDNPFSRVAQEFGSSVSQGCPAADSQRPSTVHVLSQLLRLRQCCCHLSLLKSALDPTELESEGLVLSLEEQLSALTLSKVDVSEPSPTVSLNGTCFKAELFDDTRRSTKVSSLLAELEAIQKGPGSQKSVIVSQWTSMLQVVALHLKKNRLTYATIDGSVNPKQRMDLVEAFNHSQGPQVMLISLLAGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRVGQKKDVVIHRFVCEGTVEEKILQLQEKKKDLAKQVLSGSEGPVTKLTLADLKILFGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
104	Phosphorylation	DPNPKELSVTSKPQQ CCCCCCCCCCCCCCC	25.17	25619855
106	Phosphorylation	NPKELSVTSKPQQPS CCCCCCCCCCCCCCC	27.88	25619855
107	Phosphorylation	PKELSVTSKPQQPSE CCCCCCCCCCCCCCH	39.93	25619855
113	Phosphorylation	TSKPQQPSESQLHSP CCCCCCCCHHHCCCC	45.61	25619855
115	Phosphorylation	KPQQPSESQLHSPSQ CCCCCCHHHCCCCCC	42.24	21082442
119	Phosphorylation	PSESQLHSPSQPRNP CCHHHCCCCCCCCCH	34.53	26824392
121	Phosphorylation	ESQLHSPSQPRNPFR HHHCCCCCCCCCHHH	56.69	25619855
182	Phosphorylation	SRMEKDPSSDLVATR CCCCCCCCCCCCCHH	46.77	24719451
183	Phosphorylation	RMEKDPSSDLVATRQ CCCCCCCCCCCCHHC	40.11	24719451
191	Phosphorylation	DLVATRQSGGDREEQ CCCCHHCCCCCHHHH	41.26	25338131
246	Phosphorylation	GVPNKPETLREKETQ CCCCCCHHHHHHCCE	39.37	24719451
344	Phosphorylation	GVSSRPGSPLLFDST CCCCCCCCCCEEECC	18.30	29233185
359	Phosphorylation	VDSQKKGSLQHSDQS CCCCCCCCCCCCCHH	33.46	25266776
436	Phosphorylation	ALSALALSPEQGTKE HHHHHHCCCCCCCCH	22.30	25266776
588	Phosphorylation	TMIALILTKKNQQKS HHHHHHHHHHHHHHH	32.74	24759943
772	Phosphorylation	DEFSLWKSQVDNGSM CCCCEEHHCCCCCCC	24.69	30635358
778	Phosphorylation	KSQVDNGSMKGGERL HHCCCCCCCCCHHHH	24.47	30635358
854	Phosphorylation	KRQEGRGSHHGRSPD HHHCCCCCCCCCCCC	15.79	26643407
859	Phosphorylation	RGSHHGRSPDNPFSR CCCCCCCCCCCHHHH	40.99	25266776
884	Phosphorylation	QGCPAADSQRPSTVH CCCCCCCCCCCCHHH	24.30	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TTF2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TTF2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TTF2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TTF2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.