TSP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSP4_HUMAN
• UniProt AC: P35443
• Protein Name: Thrombospondin-4
• Gene Name: THBS4
• Organism: Homo sapiens (Human).
• Sequence Length: 961
• Subcellular Localization: Endoplasmic reticulum . Sarcoplasmic reticulum . Secreted . Secreted, extracellular space . Secreted, extracellular space, extracellular matrix .
• Protein Description: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner (By similarity)..
• Protein Sequence: MLAPRGAAVLLLHLVLQRWLAAGAQATPQVFDLLPSSSQRLNPGALLPVLTDPALNDLYVISTFKLQTKSSATIFGLYSSTDNSKYFEFTVMGRLNKAILRYLKNDGKVHLVVFNNLQLADGRRHRILLRLSNLQRGAGSLELYLDCIQVDSVHNLPRAFAGPSQKPETIELRTFQRKPQDFLEELKLVVRGSLFQVASLQDCFLQQSEPLAATGTGDFNRQFLGQMTQLNQLLGEVKDLLRQQVKETSFLRNTIAECQACGPLKFQSPTPSTVVPPAPPAPPTRPPRRCDSNPCFRGVQCTDSRDGFQCGPCPEGYTGNGITCIDVDECKYHPCYPGVHCINLSPGFRCDACPVGFTGPMVQGVGISFAKSNKQVCTDIDECRNGACVPNSICVNTLGSYRCGPCKPGYTGDQIRGCKAERNCRNPELNPCSVNAQCIEERQGDVTCVCGVGWAGDGYICGKDVDIDSYPDEELPCSARNCKKDNCKYVPNSGQEDADRDGIGDACDEDADGDGILNEQDNCVLIHNVDQRNSDKDIFGDACDNCLSVLNNDQKDTDGDGRGDACDDDMDGDGIKNILDNCPKFPNRDQRDKDGDGVGDACDSCPDVSNPNQSDVDNDLVGDSCDTNQDSDGDGHQDSTDNCPTVINSAQLDTDKDGIGDECDDDDDNDGIPDLVPPGPDNCRLVPNPAQEDSNSDGVGDICESDFDQDQVIDRIDVCPENAEVTLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTQTDDDYAGFIFGYQDSSSFYVVMWKQTEQTYWQATPFRAVAEPGIQLKAVKSKTGPGEHLRNSLWHTGDTSDQVRLLWKDSRNVGWKDKVSYRWFLQHRPQVGYIRVRFYEGSELVADSGVTIDTTMRGGRLGVFCFSQENIIWSNLKYRCNDTIPEDFQEFQTQNFDRFDN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
86	Phosphorylation	SSTDNSKYFEFTVMG ECCCCCCEEEEEEEH	14.25	29116813
97	Acetylation	TVMGRLNKAILRYLK EEEHHHHHHHHHHHH	41.20	12653547
268	Phosphorylation	CGPLKFQSPTPSTVV CCCEEECCCCCCCCC	33.60	-
270	Phosphorylation	PLKFQSPTPSTVVPP CEEECCCCCCCCCCC	34.81	-
270	O-linked_Glycosylation	PLKFQSPTPSTVVPP CEEECCCCCCCCCCC	34.81	OGP
272	Phosphorylation	KFQSPTPSTVVPPAP EECCCCCCCCCCCCC	35.99	-
272	O-linked_Glycosylation	KFQSPTPSTVVPPAP EECCCCCCCCCCCCC	35.99	OGP
273	O-linked_Glycosylation	FQSPTPSTVVPPAPP ECCCCCCCCCCCCCC	27.08	OGP
612	N-linked_Glycosylation	CPDVSNPNQSDVDND CCCCCCCCHHHCCCC	59.23	UniProtKB CARBOHYD
816	Phosphorylation	YVVMWKQTEQTYWQA EEEEEEECCCCEEEC	26.74	24043423
819	Phosphorylation	MWKQTEQTYWQATPF EEEECCCCEEECCCC	22.09	24043423
941	N-linked_Glycosylation	SNLKYRCNDTIPEDF ECCCEECCCCCCHHH	40.22	UniProtKB CARBOHYD

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TSP4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TSP4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TSP4_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.