TSN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSN1_HUMAN
• UniProt AC: O60635
• Protein Name: Tetraspanin-1
• Gene Name: TSPAN1
• Organism: Homo sapiens (Human).
• Sequence Length: 241
• Subcellular Localization: Lysosome membrane ; Multi-pass membrane protein .
• Protein Sequence: MQCFSFIKTMMILFNLLIFLCGAALLAVGIWVSIDGASFLKIFGPLSSSAMQFVNVGYFLIAAGVVVFALGFLGCYGAKTESKCALVTFFFILLLIFIAEVAAAVVALVYTTMAEHFLTLLVVPAIKKDYGSQEDFTQVWNTTMKGLKCCGFTNYTDFEDSPYFKENSAFPPFCCNDNVTNTANETCTKQKAHDQKVEGCFNQLLYDIRTNAVTVGGVAAGIGGLELAAMIVSMYLYCNLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MQCFSFIKTMMI ---CCHHHHHHHHHH	33.42	24719451
38	Phosphorylation	WVSIDGASFLKIFGP HHEECCCHHHHHHCC	36.32	24961811
141	N-linked_Glycosylation	EDFTQVWNTTMKGLK HHHHHHHHHHCCCCE	27.15	19508227
141	N-linked_Glycosylation	EDFTQVWNTTMKGLK HHHHHHHHHHCCCCE	27.15	19508227
154	N-linked_Glycosylation	LKCCGFTNYTDFEDS CEECCCCCCCCCCCC	35.13	19508227
154	N-linked_Glycosylation	LKCCGFTNYTDFEDS CEECCCCCCCCCCCC	35.13	19508227
155	Phosphorylation	KCCGFTNYTDFEDSP EECCCCCCCCCCCCC	12.48	-
156	Phosphorylation	CCGFTNYTDFEDSPY ECCCCCCCCCCCCCC	35.96	-
178	N-linked_Glycosylation	PPFCCNDNVTNTANE CCCCCCCCCCCCCCH	28.64	19508227
178	N-linked_Glycosylation	PPFCCNDNVTNTANE CCCCCCCCCCCCCCH	28.64	19508227
184	N-linked_Glycosylation	DNVTNTANETCTKQK CCCCCCCCHHHHCHH	42.97	19508227
184	N-linked_Glycosylation	DNVTNTANETCTKQK CCCCCCCCHHHHCHH	42.97	19508227
196	Ubiquitination	KQKAHDQKVEGCFNQ CHHHHHHHHHHHHHH	48.59	29901268
210	Phosphorylation	QLLYDIRTNAVTVGG HHHHHHHCCCEEECH	28.06	27174698
214	Phosphorylation	DIRTNAVTVGGVAAG HHHCCCEEECHHHHC	15.83	27174698

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TSN1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TSN1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TSN1_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Glycosylation of tetraspanin Tspan-1 at four distinct sites promotesits transition through the endoplasmic reticulum.";
Scholz C.-J., Sauer G., Deissler H.;
Protein Pept. Lett. 16:1244-1248(2009).
Cited for: SUBCELLULAR LOCATION, GLYCOSYLATION AT ASN-141; ASN-154; ASN-178 ANDASN-184, AND MUTAGENESIS OF ASN-141; ASN-154; ASN-178 AND ASN-184.
PubMed: 19508227