| UniProt ID | TSN14_HUMAN | |
|---|---|---|
| UniProt AC | Q8NG11 | |
| Protein Name | Tetraspanin-14 | |
| Gene Name | TSPAN14 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 270 | |
| Subcellular Localization |
Cell membrane Multi-pass membrane protein . |
|
| Protein Description | Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. [PubMed: 26668317] | |
| Protein Sequence | MHYYRYSNAKVSCWYKYLLFSYNIIFWLAGVVFLGVGLWAWSEKGVLSDLTKVTRMHGIDPVVLVLMVGVVMFTLGFAGCVGALRENICLLNFFCGTIVLIFFLELAVAVLAFLFQDWVRDRFREFFESNIKSYRDDIDLQNLIDSLQKANQCCGAYGPEDWDLNVYFNCSGASYSREKCGVPFSCCVPDPAQKVVNTQCGYDVRIQLKSKWDESIFTKGCIQALESWLPRNIYIVAGVFIAISLLQIFGIFLARTLISDIEAVKAGHHF | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MHYYRYSNAK -----CCCCCCCCCC | 6.58 | 25884760 | |
| 52 | Ubiquitination | GVLSDLTKVTRMHGI CHHHCHHHHHHHCCC | 49.24 | 33845483 | |
| 52 (in isoform 1) | Ubiquitination | - | 49.24 | 21890473 | |
| 54 | Phosphorylation | LSDLTKVTRMHGIDP HHCHHHHHHHCCCCH | 24.67 | 24719451 | |
| 88 | Ubiquitination | VGALRENICLLNFFC HHHHHHHCHHHHHHH | 1.18 | 29967540 | |
| 142 | Ubiquitination | RDDIDLQNLIDSLQK HCCCCHHHHHHHHHH | 46.38 | 21890473 | |
| 142 | Ubiquitination | RDDIDLQNLIDSLQK HCCCCHHHHHHHHHH | 46.38 | 21890473 | |
| 169 | N-linked_Glycosylation | WDLNVYFNCSGASYS CEEEEEEECCCCCCC | 11.02 | UniProtKB CARBOHYD | |
| 179 | Ubiquitination | GASYSREKCGVPFSC CCCCCHHHHCCCCCE | 34.87 | - | |
| 180 | S-palmitoylation | ASYSREKCGVPFSCC CCCCHHHHCCCCCEE | 5.94 | 21044946 | |
| 186 | S-palmitoylation | KCGVPFSCCVPDPAQ HHCCCCCEECCCHHH | 2.51 | 21044946 | |
| 187 | S-palmitoylation | CGVPFSCCVPDPAQK HCCCCCEECCCHHHH | 4.89 | 21044946 | |
| 194 | Ubiquitination | CVPDPAQKVVNTQCG ECCCHHHHHHHCCCC | 50.70 | - | |
| 194 (in isoform 2) | Ubiquitination | - | 50.70 | 21890473 | |
| 211 | Ubiquitination | VRIQLKSKWDESIFT EEEEEECCCCHHHCC | 58.01 | 2190698 | |
| 211 (in isoform 1) | Ubiquitination | - | 58.01 | 21890473 | |
| 235 | Ubiquitination | WLPRNIYIVAGVFIA CCCCCCHHHHHHHHH | 1.19 | 21890473 | |
| 248 | Ubiquitination | IAISLLQIFGIFLAR HHHHHHHHHHHHHHH | 3.26 | 21890473 | |
| 248 (in isoform 2) | Ubiquitination | - | 3.26 | 21890473 | |
| 256 | Phosphorylation | FGIFLARTLISDIEA HHHHHHHHHHHHHHH | 23.88 | 19413330 | |
| 259 | Phosphorylation | FLARTLISDIEAVKA HHHHHHHHHHHHHHC | 35.33 | 19413330 | |
| 265 (in isoform 1) | Ubiquitination | - | 56.55 | 21890473 | |
| 265 | Ubiquitination | ISDIEAVKAGHHF-- HHHHHHHHCCCCC-- | 56.55 | 33845483 | |
| 279 | Ubiquitination | ---------------- ---------------- | 21890473 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TSN14_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TSN14_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TSN14_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ADA10_HUMAN | ADAM10 | physical | 23091066 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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