TSH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSH1_HUMAN
• UniProt AC: Q6ZSZ6
• Protein Name: Teashirt homolog 1
• Gene Name: TSHZ1
• Organism: Homo sapiens (Human).
• Sequence Length: 1077
• Subcellular Localization: Nucleus .
• Protein Description: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential)..
• Protein Sequence: MPRRKQQAPRRSAAYVPEEELKAAEIDEEHVEDDGLSLDIQESEYMCNEETEIKEAQSYQNSPVSSATNQDAGYGSPFSESSDQLAHFKGSSSREEKEDPQCPDSVSYPQDSLAQIKAVYANLFSESCWSSLALDLKKSGSTTSTNDASQKESSAPTPTPPTCPVSTTGPTTSTPSTSCSSSTSHSSTTSTSSSSGYDWHQAALAKTLQQTSSYGLLPEPSLFSTVQLYRQNNKLYGSVFTGASKFRCKDCSAAYDTLVELTVHMNETGHYRDDNRDKDSEKTKRWSKPRKRSLMEMEGKEDAQKVLKCMYCGHSFESLQDLSVHMIKTKHYQKVPLKEPVPAITKLVPSTKKRALQDLAPPCSPEPAGMAAEVALSESAKDQKAANPYVTPNNRYGYQNGASYTWQFEARKAQILKCMECGSSHDTLQQLTAHMMVTGHFLKVTTSASKKGKQLVLDPVVEEKIQSIPLPPTTHTRLPASSIKKQPDSPAGSTTSEEKKEPEKEKPPVAGDAEKIKEESEDSLEKFEPSTLYPYLREEDLDDSPKGGLDILKSLENTVSTAISKAQNGAPSWGGYPSIHAAYQLPGTVKPLPAAVQSVQVQPSYAGGVKSLSSAEHNALLHSPGSLTPPPHKSNVSAMEELVEKVTGKVNIKKEERPPEKEKSSLAKAASPIAKENKDFPKTEEVSGKPQKKGPEAETGKAKKEGPLDVHTPNGTEPLKAKVTNGCNNLGIIMDHSPEPSFINPLSALQSIMNTHLGKVSKPVSPSLDPLAMLYKISNSMLDKPVYPATPVKQADAIDRYYYENSDQPIDLTKSKNKPLVSSVADSVASPLRESALMDISDMVKNLTGRLTPKSSTPSTVSEKSDADGSSFEEALDELSPVHKRKGRQSNWNPQHLLILQAQFASSLRETTEGKYIMSDLGPQERVHISKFTGLSMTTISHWLANVKYQLRRTGGTKFLKNLDTGHPVFFCNDCASQFRTASTYISHLETHLGFSLKDLSKLPLNQIQEQQNVSKVLTNKTLGPLGATEEDLGSTFQCKLCNRTFASKHAVKLHLSKTHGKSPEDHLIYVTELEKQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	TEIKEAQSYQNSPVS HHHHHHHHHCCCCCC	35.42	27080861
59	Phosphorylation	EIKEAQSYQNSPVSS HHHHHHHHCCCCCCC	10.30	27080861
62	Phosphorylation	EAQSYQNSPVSSATN HHHHHCCCCCCCCCC	15.91	27080861
65	Phosphorylation	SYQNSPVSSATNQDA HHCCCCCCCCCCCCC	20.03	27080861
66	Phosphorylation	YQNSPVSSATNQDAG HCCCCCCCCCCCCCC	39.07	27080861
68	Phosphorylation	NSPVSSATNQDAGYG CCCCCCCCCCCCCCC	35.05	27080861
74	Phosphorylation	ATNQDAGYGSPFSES CCCCCCCCCCCCCCC	19.02	27080861
76	Phosphorylation	NQDAGYGSPFSESSD CCCCCCCCCCCCCHH	17.81	27080861
89	Ubiquitination	SDQLAHFKGSSSREE HHHHHHCCCCCCCCC	48.27	-
139	Phosphorylation	LALDLKKSGSTTSTN HHHHHHHCCCCCCCC	36.07	22210691
149	Phosphorylation	TTSTNDASQKESSAP CCCCCCHHHCCCCCC	44.65	22210691
248	Phosphorylation	TGASKFRCKDCSAAY CCCCCCCCCCCHHHH	4.99	27251275
278	Acetylation	YRDDNRDKDSEKTKR CCCCCCCCCCHHHHH	60.97	7710377
287	Phosphorylation	SEKTKRWSKPRKRSL CHHHHHCCCCCHHHH	36.49	22468782
293	Phosphorylation	WSKPRKRSLMEMEGK CCCCCHHHHHHHCCH	34.79	28555341
318	Phosphorylation	YCGHSFESLQDLSVH HCCCCHHHHHHHHHH	29.35	30631047
319	Phosphorylation	CGHSFESLQDLSVHM CCCCHHHHHHHHHHE	3.46	27251275
332	Phosphorylation	HMIKTKHYQKVPLKE HEECCCCCCCCCCCC	16.16	-
334	Ubiquitination	IKTKHYQKVPLKEPV ECCCCCCCCCCCCCC	38.36	-
364	Phosphorylation	QDLAPPCSPEPAGMA HHHCCCCCCCHHHHH	37.76	30576142
379	Phosphorylation	AEVALSESAKDQKAA HHHHHCHHHCCHHCC	36.92	-
389	Phosphorylation	DQKAANPYVTPNNRY CHHCCCCCCCCCCCC	19.43	27642862
391	Phosphorylation	KAANPYVTPNNRYGY HCCCCCCCCCCCCCC	17.92	28555341
444	Phosphorylation	VTGHFLKVTTSASKK HHCCEEEEECCCCCC	8.42	27251275
447	Phosphorylation	HFLKVTTSASKKGKQ CEEEEECCCCCCCCE	22.60	-
467	Phosphorylation	VVEEKIQSIPLPPTT HHHHHHHCCCCCCCC	29.64	22210691
474	Phosphorylation	SIPLPPTTHTRLPAS CCCCCCCCCCCCCHH	27.33	22210691
476	Phosphorylation	PLPPTTHTRLPASSI CCCCCCCCCCCHHHC	31.63	22210691
478	Phosphorylation	PPTTHTRLPASSIKK CCCCCCCCCHHHCCC	4.34	27251275
482	Phosphorylation	HTRLPASSIKKQPDS CCCCCHHHCCCCCCC	40.30	-
484	Acetylation	RLPASSIKKQPDSPA CCCHHHCCCCCCCCC	47.51	25953088
489	Phosphorylation	SIKKQPDSPAGSTTS HCCCCCCCCCCCCCH	24.27	29255136
493	Phosphorylation	QPDSPAGSTTSEEKK CCCCCCCCCCHHHHC	30.53	30242111
494	Phosphorylation	PDSPAGSTTSEEKKE CCCCCCCCCHHHHCC	33.16	30242111
495	Phosphorylation	DSPAGSTTSEEKKEP CCCCCCCCHHHHCCC	35.52	29449344
496	Phosphorylation	SPAGSTTSEEKKEPE CCCCCCCHHHHCCCC	43.79	27251275
517	Sumoylation	AGDAEKIKEESEDSL CCCHHHHHHHCHHHH	67.51	-
520	Phosphorylation	AEKIKEESEDSLEKF HHHHHHHCHHHHHHC	48.04	20873877
523	Phosphorylation	IKEESEDSLEKFEPS HHHHCHHHHHHCCHH	34.08	20873877
530	Phosphorylation	SLEKFEPSTLYPYLR HHHHCCHHHHHHHCC	24.68	26657352
531	Phosphorylation	LEKFEPSTLYPYLRE HHHCCHHHHHHHCCH	40.81	26657352
533	Phosphorylation	KFEPSTLYPYLREED HCCHHHHHHHCCHHC	7.01	20873877
544	Phosphorylation	REEDLDDSPKGGLDI CHHCCCCCCCCCHHH	28.33	26657352
554	Phosphorylation	GGLDILKSLENTVST CCHHHHHHHHHHHHH	37.15	28555341
583	Phosphorylation	YPSIHAAYQLPGTVK CCCHHHHEECCCCCC	16.03	27251275
623	Phosphorylation	EHNALLHSPGSLTPP HCHHHCCCCCCCCCC	30.81	21712546
626	Phosphorylation	ALLHSPGSLTPPPHK HHCCCCCCCCCCCCC	32.24	21712546
628	Phosphorylation	LHSPGSLTPPPHKSN CCCCCCCCCCCCCCC	35.13	27080861
671	Phosphorylation	SSLAKAASPIAKENK CHHHHHHCHHHHHCC	23.00	26546556
712	Phosphorylation	EGPLDVHTPNGTEPL CCCCCCCCCCCCCCC	20.49	25159151
720	Phosphorylation	PNGTEPLKAKVTNGC CCCCCCCEEEECCCC	57.80	24719451
761	Phosphorylation	NTHLGKVSKPVSPSL HHCCCCCCCCCCCCC	34.43	28450419
765	Phosphorylation	GKVSKPVSPSLDPLA CCCCCCCCCCCCHHH	19.80	21712546
767	Phosphorylation	VSKPVSPSLDPLAML CCCCCCCCCCHHHHH	37.59	28450419
780	Phosphorylation	MLYKISNSMLDKPVY HHHHHHHHHCCCCCC	17.58	28555341
790	Phosphorylation	DKPVYPATPVKQADA CCCCCCCCCCCCCHH	24.90	28122231
807	Phosphorylation	RYYYENSDQPIDLTK HHHCCCCCCCCCCCC	70.61	24719451
813	Phosphorylation	SDQPIDLTKSKNKPL CCCCCCCCCCCCCCC	29.53	28555341
814	Ubiquitination	DQPIDLTKSKNKPLV CCCCCCCCCCCCCCH	67.73	-
822	Phosphorylation	SKNKPLVSSVADSVA CCCCCCHHHHHHHHC	27.12	-
823	Phosphorylation	KNKPLVSSVADSVAS CCCCCHHHHHHHHCH	17.53	29978859
827	Phosphorylation	LVSSVADSVASPLRE CHHHHHHHHCHHHHH	15.17	29978859
830	Phosphorylation	SVADSVASPLRESAL HHHHHHCHHHHHHHH	23.47	29978859
835	Phosphorylation	VASPLRESALMDISD HCHHHHHHHHHHHHH	21.92	24719451
841	Phosphorylation	ESALMDISDMVKNLT HHHHHHHHHHHHHHH	18.52	24719451
848	Phosphorylation	SDMVKNLTGRLTPKS HHHHHHHHCCCCCCC	29.65	24719451
852	Phosphorylation	KNLTGRLTPKSSTPS HHHHCCCCCCCCCCC	27.58	24719451
852	O-linked_Glycosylation	KNLTGRLTPKSSTPS HHHHCCCCCCCCCCC	27.58	30379171
854	Ubiquitination	LTGRLTPKSSTPSTV HHCCCCCCCCCCCCC	52.37	-
870	Phosphorylation	EKSDADGSSFEEALD CCCCCCCCCHHHHHH	32.19	27732954
871	Phosphorylation	KSDADGSSFEEALDE CCCCCCCCHHHHHHH	42.05	27732954
880	Phosphorylation	EEALDELSPVHKRKG HHHHHHCCHHHHCCC	23.87	27732954
916	Phosphorylation	RETTEGKYIMSDLGP HHHHCCCEEECCCCH	16.83	29083192
919	Phosphorylation	TEGKYIMSDLGPQER HCCCEEECCCCHHHC	21.81	27050516
941	Phosphorylation	GLSMTTISHWLANVK CCCHHHHHHHHHHHH	13.40	27251275
1016	Ubiquitination	QEQQNVSKVLTNKTL HHHHCHHHHHHCCCC	36.66	-
1029	Phosphorylation	TLGPLGATEEDLGST CCCCCCCCHHHHCCC	37.80	29759185
1035	Phosphorylation	ATEEDLGSTFQCKLC CCHHHHCCCEEHHHC	33.09	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TSH1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TSH1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APBB1_HUMAN	APBB1	physical	19343227

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.