TSG6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TSG6_HUMAN
• UniProt AC: P98066
• Protein Name: Tumor necrosis factor-inducible gene 6 protein
• Gene Name: TNFAIP6
• Organism: Homo sapiens (Human).
• Sequence Length: 277
• Protein Description: Possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis..
• Protein Sequence: MIILIYLFLLLWEDTQGWGFKDGIFHNSIWLERAAGVYHREARSGKYKLTYAEAKAVCEFEGGHLATYKQLEAARKIGFHVCAAGWMAKGRVGYPIVKPGPNCGFGKTGIIDYGIRLNRSERWDAYCYNPHAKECGGVFTDPKQIFKSPGFPNEYEDNQICYWHIRLKYGQRIHLSFLDFDLEDDPGCLADYVEIYDSYDDVHGFVGRYCGDELPDDIISTGNVMTLKFLSDASVTAGGFQIKYVAMDPVSKSSQGKNTSTTSTGNKNFLAGRFSHL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	LERAAGVYHREARSG HHHHCCCEEHHHHCC	8.34	24719451
118	N-linked_Glycosylation	IDYGIRLNRSERWDA EECEEECCCHHCCEE	35.27	UniProtKB CARBOHYD
148	Phosphorylation	DPKQIFKSPGFPNEY CHHHHHCCCCCCCCC	21.36	-
155	Phosphorylation	SPGFPNEYEDNQICY CCCCCCCCCCCCEEE	34.91	-
258	N-linked_Glycosylation	SKSSQGKNTSTTSTG CCCCCCCCCCCCCCC	46.19	UniProtKB CARBOHYD
259	Phosphorylation	KSSQGKNTSTTSTGN CCCCCCCCCCCCCCC	30.82	22817900
262	Phosphorylation	QGKNTSTTSTGNKNF CCCCCCCCCCCCCCE	24.86	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TSG6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TSG6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
148	Phosphorylation	144 (4)	Q ⇒ R	rs1046668	Blood protein levels	28240269

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-259 AND THR-262, ANDMASS SPECTROMETRY.
PubMed: 17287340