dbPTM

TRXR1_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TRXR1_RAT
UniProt AC	O89049
Protein Name	Thioredoxin reductase 1, cytoplasmic
Gene Name	Txnrd1
Organism	Rattus norvegicus (Rat).
Sequence Length	499
Subcellular Localization	Cytoplasm.
Protein Description
Protein Sequence	MNDSKDAPKSYDFDLIIIGGGSGGLAAAKEAAKFDKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALKDSRNYGWKLEDTVKHDWEKMTESVQNHIGSLNWGYRVALREKKVVYENAYGKFIGPHKIMATNNKGKEKVYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPTKIEQIEAGTPGRLKVTAKSTNSEETIEDEFNTVLLAVGRDSCTRTIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEGKLELTPVAIQAGRLLAQRLYGGSTVKCDYDNVPTTVFTPLEYGCCGLSEEKAVEKFGEENIEVYHSFFWPLEWTVPSRDNNKCYAKVICNLKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKQQLDSTIGIHPVCAEIFTTLSVTKRSGGDILQSGCUG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Acetylation	AAAKEAAKFDKKVMV HHHHHHHHCCCEEEE	62.23	22902405
68	Succinylation	NVGCIPKKLMHQAAL ECCCCCHHHHHHHHH	45.76	-
68	Succinylation	NVGCIPKKLMHQAAL ECCCCCHHHHHHHHH	45.76	-
131	Phosphorylation	KVVYENAYGKFIGPH EEEEECCCCCCCCCC	32.22	-
133	Acetylation	VYENAYGKFIGPHKI EEECCCCCCCCCCCE	22.57	22902405
139	Acetylation	GKFIGPHKIMATNNK CCCCCCCCEEEECCC	36.99	22902405
150	Acetylation	TNNKGKEKVYSAERF ECCCCCCEEEECEEE	50.38	22902405
263	Phosphorylation	IEQIEAGTPGRLKVT HHEECCCCCCEEEEE	29.62	28432305
308	Acetylation	GLETVGVKINEKTGK CCEEEEEEEECCCCC	33.61	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TRXR1_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TRXR1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TRXR1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of TRXR1_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TRXR1_RAT

Related Literatures of Post-Translational Modification