TRPM3_HUMAN - dbPTM
TRPM3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TRPM3_HUMAN
UniProt AC Q9HCF6
Protein Name Transient receptor potential cation channel subfamily M member 3
Gene Name TRPM3
Organism Homo sapiens (Human).
Sequence Length 1732
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description Calcium channel mediating constitutive calcium ion entry. Its activity is increased by reduction in extracellular osmolarity, by store depletion and muscarinic receptor activation..
Protein Sequence MPEPWGTVYFLGIAQVFSFLFSWWNLEGVMNQADAPRPLNWTIRKLCHAAFLPSVRLLKAQKSWIERAFYKRECVHIIPSTKDPHRCCCGRLIGQHVGLTPSISVLQNEKNESRLSRNDIQSEKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMSNPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPFFSLDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLDDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLGIEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQNETREDGKIIQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNTFKLQESIDPAGEETMSPTSPTLMPRMRSHSFYSVNMKDKGGIEKLESIFKERSLSLHRATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDPLDNSVNILGLGEPSFSTPVPSTAPSSSAYATLAPTDRPPSRSIDFEDITSMDTRSFSSDYTHLPECQNPWDSEPPMYHTIERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFGVPVKTAEYTSITDCIDTRCVNAPQAIADRAAFPGGLGDKVEDLTCCHPEREAELSHPSSDSEENEAKGRRATIAISSQEGDNSERTLSNNITVPKIERANSYSAEEPSAPYAHTRKSFSISDKLDRQRNTASLRNPFQRSKSSKPEGRGDSLSMRRLSRTSAFQSFESKHN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
63PhosphorylationRLLKAQKSWIERAFY
HHHHHCHHHHHHHHH		22.6223927012
100PhosphorylationIGQHVGLTPSISVLQ
HHCCCCCCCCHHHHH		14.7327067055
102PhosphorylationQHVGLTPSISVLQNE
CCCCCCCCHHHHHCC		23.4327067055
104PhosphorylationVGLTPSISVLQNEKN
CCCCCCHHHHHCCCC		22.5527067055
126PhosphorylationDIQSEKWSISKHTQL
HHHHHCCCCCCCCCC		28.2225307156
290PhosphorylationTVLNSMHSHFILADN
HHHHHCCCCEEEECC		16.0824719451
318PhosphorylationRQLEKHISLQKINTR
HHHHHHCCHHHCCCC		25.1924719451
394PhosphorylationCDGSGRASDILAFGH
ECCCCCHHHHHHHCC		24.6722210691
413PhosphorylationEGGLINESLRDQLLV
CCCCCCHHHHHHHCC		24.9822210691
428PhosphorylationTIQKTFTYTRTQAQH
EEECCEECCHHHHHH		7.05-
576PhosphorylationKGNLPPDYRISLIDI
CCCCCCCCCEEEHHH		18.6724043423
579PhosphorylationLPPDYRISLIDIGLV
CCCCCCEEEHHHHHH		15.4124043423
589PhosphorylationDIGLVIEYLMGGAYR
HHHHHHHHHHCCCHH		7.2924043423
595PhosphorylationEYLMGGAYRCNYTRK
HHHHCCCHHCCCHHH		20.9724043423
599PhosphorylationGGAYRCNYTRKRFRT
CCCHHCCCHHHHHHH		16.1424043423
600PhosphorylationGAYRCNYTRKRFRTL
CCHHCCCHHHHHHHH		18.7424043423
608PhosphorylationRKRFRTLYHNLFGPK
HHHHHHHHHHHHCCC		6.50-
749PhosphorylationQLAMKLLTYELKNWS
HHHHHHHHHHHHCCC		25.94-
865PhosphorylationLGRNNGESSRKKDEE
HCCCCCCCCCCCCHH		36.5229209046
866PhosphorylationGRNNGESSRKKDEEE
CCCCCCCCCCCCHHH		43.7629209046
876PhosphorylationKDEEEVQSKHRLIPL
CCHHHHHHHHCCCCH		35.2929083192
965PhosphorylationVKVWLQEYWNVTDLI
HHHHHHHHCCHHHHH		6.85-
978PhosphorylationLIAILLFSVGMILRL
HHHHHHHHHHHHHHH		20.10-
1046PhosphorylationIMLVVLMSFGVARQA
HHHHHHHHHCHHHHH		18.06-
1062PhosphorylationLFPNEEPSWKLAKNI
CCCCCCCCHHHHHHH		39.8723403867
1157PhosphorylationQVWKFQRYQLIMTFH
CHHHEEEEEEHHHHC		9.26-
1273PhosphorylationSMKASLQTVDIRLAQ
HHHHHHHHHHHHHHH		25.9923403867
1319PhosphorylationSDCTDAAYIVRQSSF
CCCCCHHHHHHHHHC		11.1522468782
1324PhosphorylationAAYIVRQSSFNSQEG
HHHHHHHHHCCCCCC		26.7422210691
1328PhosphorylationVRQSSFNSQEGNTFK
HHHHHCCCCCCCEEE		27.8322468782
1333PhosphorylationFNSQEGNTFKLQESI
CCCCCCCEEEEEEEE		32.7622210691
1354PhosphorylationTMSPTSPTLMPRMRS
CCCCCCCCCCCCCCC		35.1422210691
1380PhosphorylationGGIEKLESIFKERSL
CHHHHHHHHHHHHCC		43.7024719451
1388PhosphorylationIFKERSLSLHRATSS
HHHHHCCCHHHCCCC		24.31-
1393PhosphorylationSLSLHRATSSHSVAK
CCCHHHCCCCCCCCC		30.62-
1418PhosphorylationTLAIVPDSRRPSSCI
CEEECCCCCCCCCCH		24.9022210691
1612PhosphorylationTCCHPEREAELSHPS
CCCCCHHHHHHCCCC		44.8524719451
1620PhosphorylationAELSHPSSDSEENEA
HHHCCCCCCCHHHHH		50.0025307156
1628PhosphorylationDSEENEAKGRRATIA
CCHHHHHHCCCEEEE		46.9324719451
1637PhosphorylationRRATIAISSQEGDNS
CCEEEEEECCCCCCC		19.5624719451
1647PhosphorylationEGDNSERTLSNNITV
CCCCCCCEECCCCCC		30.41-
1653PhosphorylationRTLSNNITVPKIERA
CEECCCCCCCCCEEC		32.6424719451
1678PhosphorylationPYAHTRKSFSISDKL
CCCCCCCCCCHHHHH		22.4227134283
1680PhosphorylationAHTRKSFSISDKLDR
CCCCCCCCHHHHHHH		28.4227134283
1682PhosphorylationTRKSFSISDKLDRQR
CCCCCCHHHHHHHCC		27.7427134283
1691PhosphorylationKLDRQRNTASLRNPF
HHHHCCCHHHHCCHH		21.5830576142
1693PhosphorylationDRQRNTASLRNPFQR
HHCCCHHHHCCHHHH		26.3130576142
1693O-linked_GlycosylationDRQRNTASLRNPFQR
HHCCCHHHHCCHHHH		26.3130620550
1703PhosphorylationNPFQRSKSSKPEGRG
CHHHHCCCCCCCCCC		44.8628176443
1726PhosphorylationSRTSAFQSFESKHN-
HCHHHHHHHHHCCC-		25.24-
1729PhosphorylationSAFQSFESKHN----
HHHHHHHHCCC----		36.89-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TRPM3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TRPM3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TRPM3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TRPM3_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TRPM3_HUMAN

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Related Literatures of Post-Translational Modification

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