TRPC5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRPC5_MOUSE
• UniProt AC: Q9QX29
• Protein Name: Short transient receptor potential channel 5
• Gene Name: Trpc5
• Organism: Mus musculus (Mouse).
• Sequence Length: 975
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion..
• Protein Sequence: MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLSAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRKPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRHNLRSFTERHADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTNEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRRSLSTSSADFSQRDDTNDGSGGARAKSKSVSFNVGCKKKACHGAPLIRTVPRASGAQGKPKSESSSKRSFMGPSFKKLGLFFSKFNGQTSEPTSEPMYTISDGIAQQHCMWQDIRYSQMEKGKAEACSQSQMNLGEVELGEIRGAAARSSECPLACSSSLHCASGICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
129	Phosphorylation	SGEKQVPTLMMDTQF CCCCCCCCEEECCCC	28.56	-
289	Acetylation	QKYHDLAKLKVAIKY HHHHHHHHHHHHHHH	57.02	19852241
291	Acetylation	YHDLAKLKVAIKYHQ HHHHHHHHHHHHHHH	28.99	19852249
461	N-linked_Glycosylation	IVAYVKYNGSRPREE EEEEEECCCCCCHHH	35.92	-
489	Phosphorylation	FAISNILSSLRLISL HHHHHHHHHHHHHHH	24.43	25159016
490	Phosphorylation	AISNILSSLRLISLF HHHHHHHHHHHHHHH	17.67	25159016
498	Phosphorylation	LRLISLFTANSHLGP HHHHHHHHCCCCCCH	30.17	20139300
972	Phosphorylation	DGQEEQVTTRL---- CCCCCCCCCCC----	13.09	15843439

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRPC5_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRPC5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRPC5_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TRPC5_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.